A5015673436- Magnolia and Illicium research
- Oxidative Organic Chemistry Reactions
- Phagocytosis and Immune Regulation
- Pancreatic and Hepatic Oncology Research
- Genomics, phytochemicals, and oxidative stress
- Flavonoids in Medical Research
- Phytochemistry and Biological Activities
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Bioactive Compounds and Antitumor Agents
- Autophagy in Disease and Therapy
- Cancer Mechanisms and Therapy
- Echinoderm biology and ecology
- Curcumin's Biomedical Applications
- Synthesis of Indole Derivatives
- HER2/EGFR in Cancer Research
- Fungal Plant Pathogen Control
- Cell death mechanisms and regulation
- Synthesis and Biological Activity
- Natural product bioactivities and synthesis
- Telomeres, Telomerase, and Senescence
- Chronic Myeloid Leukemia Treatments
- Carcinogens and Genotoxicity Assessment
- Lung Cancer Treatments and Mutations
- Ginkgo biloba and Cashew Applications
Boston Children's Hospital
2020-2025
Harvard University
2020-2025
Boston Children's Museum
2023-2024
Jawaharlal Nehru University
2018-2022
Central University of Gujarat
2016-2019
During the past two decades, significant advances have been made in discovery and development of targeted inhibitors aimed at improving survival rates cancer patients. Among multitude potential therapeutic targets identified thus far, Receptor Tyrosine Kinases (RTKs) are particular importance. Dysregulation RTKs has implicated numerous human diseases, particularly cancer, where aberrant signaling pathways contribute to disease progression. a profound impact on intra intercellular...
The anticancer effects of fisetin, a dietary agent, are largely unknown against human gastric cancer. Herein, we investigated the mechanisms fisetin-induced inhibition growth and survival carcinoma AGS SNU-1 cells. Fisetin (25-100 μM) caused significant decrease in levels G1 phase cyclins CDKs, increased p53 its S15 phosphorylation cancer We also observed that suppression death non-neoplastic intestinal FHs74int cells were minimally affected by fisetin. strongly apoptotic showed...
Receptor tyrosine kinase (RTK), c-Met, is overexpressed and hyper active in renal cell carcinoma (RCC). Most of the therapeutic agents mediate cancer death through increased oxidative stress. Induction c-Met cells promotes activation redox-sensitive transcription factor Nrf2 cytoprotective heme oxygenase-1 (HO-1), which can resistance against c-Met/RTK inhibitor, Cabozantinib, has been approved for treatment advanced RCC. However, acquired drug a major hurdle clinical use cabozantinib....
Plumbagin, an important phytochemical from the roots of medicinal plant Plumbago zeylanica L. has shown many biological activities. The this have been in use Indian system medicine for more than twenty five centuries treatments various ailments. It anticancer activities, however, and anti-metastatic effects plumbagin are largely unknown against cervical cancer cells. Herein, we investigated molecular alterations associated with plumbagin-mediated inhibition growth, survival epithelial to...
Therapeutic resistance remains a significant challenge in cancer treatment, often resulting relapse and poor outcomes. Conventional chemotherapies, such as cisplatin paclitaxel, are frequently undermined by the development of chemoresistance systemic toxicity. Targeted therapies, receptor tyrosine kinase (RTKs) inhibitors monoclonal antibodies (mAbs), offer better specificity but face over time. Combination therapies being explored to improve efficacy mitigate resistance. Honokiol,...
The therapeutic toxicity and resistance to currently available treatment options are major clinical challenges for the management of lung cancer. As a novel strategy, we synthesized analogues known flavonol, fisetin, which has shown anti-tumorigenic potential against cancer in cell culture with no adverse effects animal models. We studied synthetic fisetin their anti-cancer cells, mice efficacy xenograft model. Brominated were screened on viability A549 H1299 three (3a, 3b, 3c), showed...
The mTOR inhibitor Rapamycin has tumor inhibitory properties; and it is also used as an immunosuppressive agent after organ transplantation. However, prolonged treatment re-activates Akt can promote cancer growth. Honokiol a natural compound with both anti-tumorigenic anti-inflammatory properties. Here, we assessed the anti-tumor effects of combination in renal cell carcinoma (RCC). Receptor tyrosine kinase c-Met-mediated signaling plays major role RCC We observed that compared alone, +...
Abstract Background c-Met, a receptor tyrosine kinase (RTK), is overexpressed in renal cell carcinoma (RCC) and correlates with decreased survival rate. Upon binding to its specific ligand, Hepatocyte Growth Factor (HGF), c-Met activates pro-tumorigenic signaling pathways. Cabozantinib (Cabo) inhibits few other RTKs, including AXL, approved for the treatment of patients advanced-stage RCC. AXL GAS6, are RCC also markers poor prognosis. The role potential crosstalk cancer need be thoroughly...
Renal Cell Carcinoma (RCC) often becomes resistant to targeted therapies, and in addition, dose-dependent toxicities limit the effectiveness of therapeutic agents. Therefore, identifying novel drug delivery approaches achieve optimal dosing agents can be beneficial managing attain effects. Previously, we have demonstrated that Honokiol, a natural compound with potent anti-tumorigenic anti-inflammatory effects, induce cancer cell apoptosis inhibit growth renal tumors vivo . In treatment,...
Development of cancer, including renal is a major problem in immunosuppressed patients. The mTOR inhibitor Rapamycin (RAPA) used as an immunosuppressive agent patients with organ transplants and other immunological disorders; it also has antitumorigenic potential. However, long-term use RAPA causes reactivation Akt, ultimately leads to enhanced tumor growth. Honokiol (HNK) natural compound, which possesses both anti-inflammatory properties. In this study, we investigated the effect novel...
Abstract Receptor Tyrosine Kinase (RTK), c-Met, is overexpressed in renal cancer and correlates with a decreased survival rate. Upon binding its specific ligand, Hepatocyte Growth Factor (HGF), c-Met activates pro-tumorigenic signaling. c-Met/RTK inhibitors are used for the treatment of advanced cell carcinoma (RCC). However, acquired therapeutic resistance major clinical problem underlying mechanisms largely unknown. Hence, novel targets needed to overcome hurdles; RTK, AXL, can be...
Abstract Advanced stage renal cell carcinoma (RCC) often becomes resistant to the currently available therapeutic options. Receptor Tyrosine Kinase (RTK), c-Met, is overexpressed and hyperactivated in cancer; it promotes tumor-promoting pathways following binding with its ligand, Hepatocyte Growth Factor (HGF). Cabozantinib (Cabo), an inhibitor of c-Met/few other RTKs (like, AXL KDR), being used for treatment RCC. However, acquired resistance a major hurdle clinical use. Mechanism(s) drug...
Oxidative stress is a central feature of chronic diseases including cancer, atherosclerosis, diabetes, the aging process, and exposure to environmental toxins. Therefore, activating cytoprotective defense mechanisms through natural, non‐toxic nutritional interventions might provide an important avenue for improving human health. In present study, we evaluated effects herbal‐rich beverage (Cleanse For Life [CFL]) in both homogeneous solutions cellular models oxidative toxicity using HepG2...