A5084515109- Silymarin and Mushroom Poisoning
- Berberine and alkaloids research
- Cancer, Lipids, and Metabolism
- Selenium in Biological Systems
- Plant Stress Responses and Tolerance
- Synthesis and bioactivity of alkaloids
- Plant Micronutrient Interactions and Effects
- Polyamine Metabolism and Applications
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
- Urological Disorders and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Cancer, Hypoxia, and Metabolism
- Arsenic contamination and mitigation
- Phytase and its Applications
- Natural product bioactivities and synthesis
- Toxin Mechanisms and Immunotoxins
- Plant nutrient uptake and metabolism
- Aluminum toxicity and tolerance in plants and animals
- Agricultural Science and Fertilization
- Pharmacological Effects of Natural Compounds
- Cancer Cells and Metastasis
- Flavonoids in Medical Research
- Heavy metals in environment
- Cell death mechanisms and regulation
Jawaharlal Nehru University
2016-2025
University of Colorado Denver
2004-2024
University of Montana
2024
University of Colorado Anschutz Medical Campus
2002-2024
Chandragupt Institute of Management
2023-2024
Alabama State University
2024
Rajendra Institute of Medical Sciences
2019-2024
Paras Hospitals
2024
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2023-2024
Government Medical College
2022-2024
Abstract We isolated a coumarin compound decursin (C19H20O5; molecular weight 328) from Korean angelica (Angelica gigas) root and characterized it by spectroscopy. Here, for the first time, we observed that (25-100 μmol/L) treatment 24 to 96 hours strongly inhibits growth induces death in human prostate carcinoma DU145, PC-3, LNCaP cells. Furthermore, decursinol [where (CH3)2-C=CH-COO- side chain of is substituted with -OH] has much lower effects compared decursin, suggesting possible...
The anti-cancer efficacy of grape seed extract (GSE) against prostate cancer (PCA) via its anti-proliferative, pro-apoptotic and anti-angiogenic activities in both cell culture animal models have recently been described by us. GSE is a complex mixture containing gallic acid (GA), catechin (C), epicatechin (EC) several oligomers (procyanidins) C and/or EC, some which are esterified to GA. To determine components most active PCA, an ethyl acetate was separated reverse-phase high-performance...
Roots and leaves of Zea mays L. cv. Ganga Safed‐2 seedlings grown with nutrient solution containing either 10 m M KNO 3 or NH 4 Cl 5 NO had considerably higher glutamate synthase (NADH, EC 1.4.1.14) activity than the corresponding organs from without any nitrogen. The supply inorganic nitrogen for a short time, i.e. h, to roots excised also increased enzyme in these organs. This increase was more pronounced nitrate ammonium When ‐grown were incubated minus medium 24 declined considerably....
Abstract Herein, for the first time, we investigated in vivo efficacy and associated molecular biomarkers mechanisms of a chemopreventive agent, silibinin, against human colorectal carcinoma (CRC) HT29 xenograft growth. Nude mice were implanted with cells fed vehicle (carboxymethyl cellulose or phosphatidylcholine) 200 mg/kg/d dose silibinin 100 doses silybin-phytosome (5 days per week) 32 days. Silibinin inhibited tumor growth that accounted 48% (P = 0.002) decrease volume 42% 0.012) weight...
Abstract Purpose: Accumulating evidences suggest the beneficial effects of fruit-and-vegetable consumption in lowering risk various cancers, including colorectal cancer. Herein, we investigated vitro and vivo anticancer associated mechanisms grape seed extract (GSE), a rich source proanthocyanidins, against Experimental Design: Effects GSE were examined on human cancer HT29 LoVo cells culture for proliferation, cell cycle progression, apoptosis. The effect oral was tumor xenograft growth...
The chronic nature of prostate cancer growth and progression leading to metastasis provides a large window for intervention. Herein, the first time, we investigated effect associated mechanisms silibinin phosphatidylcholine (silybin-phytosome) on established tumors in transgenic adenocarcinoma mouse (TRAMP) model.Twenty-week-old TRAMP male mice having palpable tumor were fed with control or 0.5% 1%, w/w, silybin-phytosome diets 11 weeks then sacrificed.Dietary inhibited (up 60%, P < 0.001)...
Silibinin, a flavanone from milk thistle, inhibits the growth of tumors in several rodent models. We examined effects dietary silibinin on growth, progression, and angiogenesis urethane-induced lung mice.A/J mice (15 per group) were injected with urethane (1 mg/g body weight) or saline alone fed normal diets for 2 weeks, after which they containing different doses (0%-1% [wt/wt] silibinin) 18 27 weeks. Immunohistochemistry Western blot analysis used to examine enzymatic markers inflammation,...