A5058502576- Essential Oils and Antimicrobial Activity
- Phytochemical compounds biological activities
- Plant biochemistry and biosynthesis
- Piperaceae Chemical and Biological Studies
- Phytochemicals and Antioxidant Activities
- Traditional and Medicinal Uses of Annonaceae
- Insect Pest Control Strategies
- Allelopathy and phytotoxic interactions
- Natural product bioactivities and synthesis
- Biochemical and biochemical processes
- Steroid Chemistry and Biochemistry
- Ginger and Zingiberaceae research
- Biochemical Analysis and Sensing Techniques
- Weed Control and Herbicide Applications
- Olfactory and Sensory Function Studies
- Phytochemistry and Bioactive Compounds
- Pharmacological Effects of Medicinal Plants
- Phytochemistry and Bioactivity Studies
- Cancer therapeutics and mechanisms
- Advances in Cucurbitaceae Research
- Hormonal Regulation and Hypertension
- Plant Parasitism and Resistance
- Pharmacogenetics and Drug Metabolism
- Crystallization and Solubility Studies
- Moringa oleifera research and applications
North East Institute of Science and Technology
2018-2024
Academy of Scientific and Innovative Research
2021-2024
University of Oklahoma
2021-2023
Council of Scientific and Industrial Research
2014-2022
National Chemical Laboratory
2012-2021
Chichester Hospital
2019
John Wiley & Sons (United States)
2019
Indian Institute of Technology Kharagpur
1997-2016
National Metallurgical Laboratory
1997
Macrophage migration inhibitory factor (MIF) is responsible for proinflammatory reactions in various infectious and non-infectious diseases. We have investigated the mechanism of anti-inflammatory activity epoxyazadiradione, a limonoid purified from neem (Azadirachta indica) fruits, against MIF. Epoxyazadiradione inhibited tautomerase MIF both human (huMIF) malaria parasites (Plasmodium falciparum (PfMIF) Plasmodium yoelii (PyMIF)) non-competitively reversible fashion (Ki, 2.11–5.23 μm)....
Human pancreatic α-amylase (HPA) inhibitors offer an effective strategy to lower postprandial hyperglycemia via control of starch breakdown. Limonoids from Azadirachta indica known for their therapeutic potential were screened inhibition, a anti-diabetic target. Studies carried out reveal mode action so as justify hypoglycemic potential. Of the nine limonoids isolated/semi-synthesized A.indica and azadiradione exhibited inhibition with IC50 value 74.17 68.38 μM, respectively against HPA...
Breast cancer is one of the most commonly diagnosed invasive cancers among women around world. Among several subtypes, triple negative breast (TNBC) highly aggressive and chemoresistant. Treatment TNBC patients has been challenging due to heterogeneity devoid well-defined molecular targets. Thus, identification novel effective selective agents against essential. We used epoxyazadiradione assess cell viability, mitochondrial potential, ROS level, migration, apoptosis protein expression in...
The bioflavors are of high demand in food and beverage industries. current study identified reductive processes mediated by mushroom species to alter the aroma aldehyde-rich essential oils submerged culture. Neofomitella polyzonata, a polypore mushroom, reduced citronellal citral citronella oil into corresponding alcohols that altered aroma, creating new bioflavor. screening with 43 aldehydes showed its broad substrate scope within aromatic linear aldehydes, yet influenced electronic steric...
Abstract Safrole, a phenylpropene with ‘candy shop’ aroma, is abundant in nature among diverse plant genera such as Sassafras , Ocotea Cinnamomum Myristica and Piper . oil has been used extensively for long time, first by Native Americans later European settlers traditional medicine flavouring agent. Until 1960 the consumption of safrole western population, agent beer, meat, soft drinks, was unregulated. Later, recognition this phytochemical weak hepatocarcinogen demonstrated genotoxicity...
Azadirachtin-A (AzaA) from the Indian neem tree (Azadirachta indica) has insecticidal properties; however, its molecular mechanism remains elusive. The "targeted and nontargeted proteomic profiling", metabolomics, matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) imaging, gene expression, in silico analysis provided clues about action on Helicoverpa armigera. Fourth instar H. armigera larvae fed AzaA-based diet (AzaD) suffered significant mortality, growth retardation,...
Neem tree (Azadirachta indica) is one of the richest sources skeletally diverse triterpenoids and they are well-known for their broad-spectrum pharmacological insecticidal properties. However, abundance varies among tissues. Here, we delineate quantitative profiling fifteen major across various tissues including developmental stages kernel pericarp, flower, leaf, stem bark using UPLC-ESI(+)-HRMS based profiling. Transcriptome analysis was used to identify initial genes involved in isoprenoid...
Neem tree serves as a cornucopia for triterpenoids called limonoids that are of profound interest to humans due their diverse biological activities. However, the biosynthetic pathway plant employs production remains unexplored this wonder tree.Herein, we report tracing limonoid through feeding experiments using 13C isotopologues glucose in neem cell suspension. Growth and development specific spectrum seedling time dependent characteristics lines were established. Further understand role...
Psidium guajava L. (commonly known as guava) is a small tree belonging to the family Myrtaceae. It grows well in tropical and subtropical regions of world. has been used traditional medicine since long time. The different parts plant like bark, leaves fruit, cure skin ailments, stomach ache, indigestion, anti-inflammatory, diabetes, hypertension, wounds, pain relief, cough, rheumatic various other ailments. chemical composition whole guava renders it medicinal properties. essential oil...
Plai or cassumunar ginger (Zingiber montanum), mainly distributed in tropical Asia, is an essential oil-bearing rhizomatous crop belonging to the Zingiberaceae family. Rhizomes and oil of this herb are used culinary as flavoring agents, traditional medicines, aromatherapy. In study, effect different postharvest drying methods (air-, oven-drying at 40 60 °C, sun-, microwave-, freeze-drying) its sliced rhizome on yield, composition, sensory quality was investigated. The major key odorants...
Coal washery rejects (CWRs) are a major byproduct produced in coal industries. We have chemically derived biocompatible nanodiamonds (NDs) from CWRs toward wide range of biological applications. The average particle sizes the blue-emitting NDs found to be 2–3.5 nm. High-resolution transmission electron microscopy depicts crystalline structure with d-spacing 0.218 nm, which is attributed 100 lattice plane cubic diamond. Fourier infrared spectroscopy, zeta potential, and X-ray photoelectron...
Fungi pose a persistent threat to humankind with worrying indications that emerging and re-emerging pathogens (e.g., Candida auris, Coccidioides spp., drug-resistant Aspergilli, more) exhibit resistance the limited number of approved antifungals. To address this problem, our team is exploring endophytic fungi as resource for discovery new antifungal natural products. The rationale behind decision based on evidence endophytes engage plants in mutualistic relationships wherein some actively...