A5062006629- Mitochondrial Function and Pathology
- Advanced Breast Cancer Therapies
- Endoplasmic Reticulum Stress and Disease
- Heat shock proteins research
- Inflammasome and immune disorders
- Ubiquitin and proteasome pathways
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
Roswell Park Comprehensive Cancer Center
2021-2024
University of California, Irvine
2022
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative proteotoxic stress in mitochondria must be attenuated activation a ubiquitous UPRmt to promote prostate cancer (PCa) growth. Here we show that 2 key components UPRmt, heat shock 60 (HSP60, chaperonin) caseinolytic protease P (ClpP, protease), were required development advanced PCa. HSP60 ClpP expression via c-Myc...
Clear cell renal carcinoma (CC-RCC) remains one of the most deadly forms kidney cancer despite recent advancements in targeted therapeutics, including tyrosine kinase and immune checkpoint inhibitors. Unfortunately, these therapies have not been able to show better than a 16% complete response rate. In this study we evaluated cyclin-dependent inhibitor, Dinaciclib, as potential new therapeutic for CC-RCC. vitro, Dinaciclib showed anti-proliferative pro-apoptotic effects on CC-RCC lines Cell...