A5049300308- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Heme Oxygenase-1 and Carbon Monoxide
- CAR-T cell therapy research
- Neonatal Health and Biochemistry
- Cellular Mechanics and Interactions
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Philippine History and Culture
- Metabolism and Genetic Disorders
- Plant Surface Properties and Treatments
- Geographic Information Systems Studies
- Environmental Monitoring and Data Management
- Hereditary Neurological Disorders
- Alcohol Consumption and Health Effects
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
University of Massachusetts Chan Medical School
2014-2022
Indian Institute of Chemical Biology
2011
The Hippo pathway regulates the transcriptional coactivator YAP to control cell proliferation, organ size, and stem maintenance. Multiple factors, such as substrate stiffness, density, G protein–coupled receptor signaling, regulate through their effects on F-actin cytoskeleton, although mechanism is not known. Here we show that angiomotin proteins (AMOT130, AMOTL1, AMOTL2) connect architecture regulation. First, angiomotins are required relocalize cytoplasm in response various manipulations...
In recent years, gene editing technologies have made significant progress in understanding function and regulation. The Clustered regularly interspaced short palindromic repeats-CRISPR associated protein 9 (CRISPR-Cas9) system has emerged as a versatile tool for genome engineering. the last few CRISPR-Cas9 technology been widely applied to cancer research, mainly understand mechanisms of oncogenesis, drug-target identification, development various cell-based therapies. When combined with...
Abstract The transcriptional co-activator YAP controls cell proliferation, survival, and tissue regeneration in response to changes the mechanical environment. It is not known how stimuli such as tension are sensed signal transduced control activity. Here we show that LIM domain protein TRIP6 acts part of a mechanotransduction pathway at adherens junctions promote activity by inhibiting LATS1/2 kinases. Previous studies showed vinculin becomes activated tension. We inhibits Hippo signaling...