A5059572873- Silymarin and Mushroom Poisoning
- Extracellular vesicles in disease
- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Berberine and alkaloids research
- Synthesis and bioactivity of alkaloids
- Circular RNAs in diseases
- Polyamine Metabolism and Applications
- Nanoplatforms for cancer theranostics
- Heme Oxygenase-1 and Carbon Monoxide
- Bone health and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Hedgehog Signaling Pathway Studies
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Toxin Mechanisms and Immunotoxins
- Enzyme function and inhibition
- Cancer Cells and Metastasis
- Pain Mechanisms and Treatments
- Hormonal and reproductive studies
- Ubiquitin and proteasome pathways
- Parasitic Infections and Diagnostics
Wake Forest University
2017-2025
Atrium Health Wake Forest Baptist
2016-2025
Wake Forest Baptist Comprehensive Cancer Center
2017-2024
Alzheimer’s Disease Neuroimaging Initiative
2023
Union Bank of Switzerland
2023
University of Colorado Denver
2010-2022
University of Montana
2011-2022
Lovely Professional University
2018-2022
National Institute of Technology Patna
2022
Southeast Clinical Oncology Research Consortium
2020
Hypoxic conditions in prostate cancer (PCA) are associated with poor prognosis; however, precise mechanism/s through which hypoxia promotes malignant phenotype remains unclear. Here, we analyzed the role of exosomes from hypoxic PCA cells enhancing invasiveness and stemness naïve cells, as well promoting cancer-associated fibroblast (CAF) stromal (PrSC). Human LNCaP PC3 were exposed to (1% O2) or normoxic (21% conditions, secreted under (ExoHypoxic) (ExoNormoxic) isolated conditioned media....
Brain cell-derived small extracellular vesicles (sEVs) in blood offer unique cellular and molecular information related to the onset progression of Alzheimer's disease (AD). We simultaneously enriched six specific sEV subtypes from plasma analyzed a selected panel microRNAs (miRNAs) older adults with/without cognitive impairment.Total sEVs were isolated participants with normal cognition (CN; n = 11), mild impairment (MCI; MCI conversion AD dementia (MCI-AD; 6), (n 11). Various brain (from...
Silibinin, a flavanone from milk thistle, inhibits the growth of tumors in several rodent models. We examined effects dietary silibinin on growth, progression, and angiogenesis urethane-induced lung mice.A/J mice (15 per group) were injected with urethane (1 mg/g body weight) or saline alone fed normal diets for 2 weeks, after which they containing different doses (0%-1% [wt/wt] silibinin) 18 27 weeks. Immunohistochemistry Western blot analysis used to examine enzymatic markers inflammation,...
African American men in the United States have higher mortality due to prostate cancer (PCa) compared other races. One reason for this disparity is lack of in-depth understanding PCa biology Americans. For example, hypoxia tumor microenvironment associated with adverse prognosis; still, no hypoxia-related studies been reported Here, we African-American and Caucasian cells exosome secretion under normoxic (21% O
African American men face a stark prostate cancer (PCa)-related health disparity, with the highest incidence and mortality rates compared to other races. Additional innovative measures are warranted reduce this disparity. Here, we focused on identification of novel serum exosome-based "protein signature" for potential use in early detection better prognosis PCa men. Nanoparticle tracking analyses showed that healthy individuals, exosome concentration (number/ml) was increased by ~3.2-fold (P...
// Isabel R. Schlaepfer 1,* , Dhanya K. Nambiar 2,3,* Anand Ramteke 2,4,* Rahul Kumar 2 Deepanshi Dhar Chapla Agarwal 2,5 Bryan Bergman 6 Michael Graner 7 Paul Maroni 8 Rana P. Singh 3 Rajesh and Gagan Deep 1 Division of Medical Oncology, Department Medicine, University Colorado Denver, Aurora, Colorado, USA Pharmaceutical Sciences, Skaggs School Pharmacy Cancer Biology Laboratory, Life Jawaharlal Nehru University, New Delhi, India 4 Molecular Biotechnology, Tezpur Tezpur, 5 Center,...
A nontoxic Os(<sc>ii</sc>) oligothienyl complex <bold>Os-4T</bold> is an extremely potent light-responsive anticancer agent that can be activated in hypoxia and with NIR light.
Ru(<sc>ii</sc>) photosensitizers (PSs) destroy aggressive melanoma cells, triggering an immune response that leads to protection against tumor challenge and mouse survival.
Ru(II) complexes that undergo photosubstitution reactions from triplet metal-centered (
Abstract Brain‐derived extracellular vesicles (EVs) play an active role in Alzheimer's disease (AD), relaying important physiological information about their host tissues. The internal cargo of EVs is protected from degradation, making attractive AD biomarkers. However, it unclear how circulating relate to isolated disease‐vulnerable brain regions. We developed a novel method for collecting the hippocampal interstitial fluid (ISF) live mice. (EV ISF ) were via ultracentrifugation and...
Abstract Our recent studies have identified gallic acid as one of the major constituents grape seed extract showing strong in vitro anticancer efficacy against human prostate cancer cells. Herein, for first time, we established vivo chemopreventive by evaluating its activity tumor growth and progression transgenic adenocarcinoma mouse (TRAMP) model. At 4 weeks age, male TRAMP mice were fed with drinking water supplemented 0.3% 1% (w/v) until 24 age. Positive control group was regular same...
Abstract Purpose: Silibinin is currently under phase II clinical trial in prostate cancer patients; however, its antitumor effects and mechanisms are not completely understood. Herein, we studied the efficacy associated of silibinin against orthotopically growing advanced human carcinoma PC-3 tumors. Experimental Design: Athymic male mice were implanted with cells 1 week later after surgical recovery gavaged daily (100 mg/kg body weight) for 7 weeks. Results: treatment reduced lower...
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer in world; main risk factors are alcohol tobacco use. Advancements therapies have yet to improve prognosis of HNSCC. The connection between diabetes being recognized, metformin has been shown decrease incidence diabetic patients. Accordingly, here, for first time, we investigated metformin's efficacy on growth viability human HNSCC FaDU Detroit cells. Our results show that treatment (5–20 mM) dose-dependently inhibits...
A better molecular understanding of prostate carcinogenesis is warranted to devise novel targeted preventive and therapeutic strategies against cancer (PCA), a major cause mortality among men. Here, we examined the role two epithelial-to-mesenchymal transition (EMT) regulators, adherens junction protein E-cadherin its transcriptional repressor SNAI1, in regulating aggressiveness PCA cells.The growth rate human carcinoma PC3 cells with stable knock-down (ShEC-PC3) respective control (Sh-PC3)...