A5012243577- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Innovative Microfluidic and Catalytic Techniques Innovation
- Computational Drug Discovery Methods
- Machine Learning in Healthcare
- FinTech, Crowdfunding, Digital Finance
- Mycorrhizal Fungi and Plant Interactions
- Gut microbiota and health
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Machine Learning in Bioinformatics
- Plant-Microbe Interactions and Immunity
- Blockchain Technology Applications and Security
- Artificial Intelligence in Healthcare and Education
- Fungal Biology and Applications
- Genomics and Chromatin Dynamics
- Dementia and Cognitive Impairment Research
- Liver Disease Diagnosis and Treatment
- Plant Parasitism and Resistance
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Heat shock proteins research
- Digestive system and related health
- Biomedical Text Mining and Ontologies
Technical University of Munich
2022-2024
Mitochondrial dysfunction is associated with inflammatory bowel diseases (IBDs). To understand how microbial-metabolic circuits contribute to intestinal injury, we disrupt mitochondrial function in the epithelium by deleting chaperone, heat shock protein 60 (Hsp60
Alternative splicing is a major contributor to transcriptome and proteome diversity in health disease. A plethora of tools have been developed for studying alternative RNA-seq data. Previous benchmarks focused on isoform quantification mapping. They neglected event detection tools, which arguably provide the most detailed insights into process. DICAST offers modular extensible framework analysing integrating eleven splice-aware mapping eight tools. We benchmark all extensively simulated as...
Summary Trichoderma spp. are gaining popularity in agriculture and forestry due to their multifaceted roles promoting plant growth through e.g. nutrient translocation, hormone production, induction of systemic resistance, but also direct antagonism other fungi. However, the mycotrophic nature genus bears risk possible interference with native plant-beneficial fungi, such as ectomycorrhiza, rhizosphere. Such could yield unpredictable consequences for host plants these ecosystems. We...
The amount of scientific literature available is overwhelming, especially in fast-evolving fields like drug repurposing. Researchers face a significant challenge: staying up-to-date nearly impossible due to the sheer volume publications, databases, and tools available. This situation creates an urgent need for more efficient ways access integrate information from these articles. To tackle this problem, we developed “DrugRepoChatter,” tool designed help researchers navigate flood recent on...
Gene regulation is frequently altered in diseases unique and patient-specific ways. Hence, personalized strategies have been proposed to infer gene-regulatory networks. However, existing methods do not scale well as they often require recomputing the entire network per sample. Moreover, account for clinically important confounding factors such age, sex, or treatment history. Finally, a user-friendly implementation analysis interpretation of net-works missing. We present DysRegNet, method...
Abstract Alternative splicing is a major contributor to transcriptome and proteome diversity in health disease. A plethora of tools have been developed for studying alternative RNA-seq data. Previous benchmarks focused on isoform quantification mapping. They neglected event detection tools, which arguably provide the most detailed insights into process. DICAST offers modular extensible framework analysis integrating 11 splice-aware mapping eight tools. We benchmark all extensively simulated...
The amount of scientific literature available is overwhelming, especially in fast-evolving fields like drug repurposing. Researchers face a significant challenge: staying up-to-date nearly impossible due to the sheer volume publications, databases, and tools available. This situation creates an urgent need for more efficient ways access integrate information from these articles. To tackle this problem, we developed "DrugRepoChatter", tool designed help researchers navigate flood recent on...
<p class="first" dir="auto" id="d14178385e152">Understanding diseases is difficult due to a lack of insight into the underlying biological mechanisms, resulting in imprecise treatments based solely on symptoms. Disease modules offer distinct perspectives complex and establish basis for mechanistic drug repurposing. However, disease module inference does not pay attention pathway annotations. Since repurposing aims hint at pathways, this information crucial should be considered when exploring...
The amount of scientific literature available is overwhelming, especially in fast-evolving fields like drug repurposing. Researchers face a significant challenge: staying up-to-date nearly impossible due to the sheer volume publications, databases, and tools available. This situation creates an urgent need for more efficient ways access integrate information from these articles. To tackle this problem, we developed "DrugRepoChatter", tool designed help researchers navigate flood recent on...
Abstract Background and Purpose Gene regulation is frequently altered in diseases unique patient‐specific ways. Hence, personalised strategies have been proposed to infer gene‐regulatory networks. However, existing methods do not scale well because they often require recomputing the entire network per sample. Moreover, account for clinically important confounding factors such as age, sex or treatment history. Finally, a user‐friendly implementation analysis interpretation of networks...
Summary Mitochondrial dysfunction is associated with inflammatory bowel diseases (IBD). To understand how microbial-metabolic circuits contribute to intestinal tissue injury, we disrupt mitochondrial function in the epithelium by deleting heat shock protein 60 (Hsp60 Δ/ΔIEC ). While metabolic perturbation causes self-resolving regeneration disrupted absence of aryl hydrocarbon receptor ;AhR -/- ) or IL-10 ;Il10 leading IBD-like pathology. Injury absent distal colon germ-free (GF) Hsp60 mice,...
<p class="first" dir="auto" id="d11508113e155"> <b>Gene regulation is frequently altered in diseases unique and often patient-specific ways. Hence, personalized strategies have been proposed to infer gene-regulatory networks. However, existing methods do not focus on disease-specific dysregulation or lack assessment of statistical significance. Moreover, they account for clinically important confounding factors such as age, sex, treatment history. To overcome these shortcomings, we present...