A5035673248- RNA Research and Splicing
- Gut microbiota and health
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Diet and metabolism studies
- Digestive system and related health
- Liver Disease Diagnosis and Treatment
- Heat shock proteins research
Ludwig-Maximilians-Universität München
2024
Technical University of Munich
2022-2023
Mitochondrial dysfunction is associated with inflammatory bowel diseases (IBDs). To understand how microbial-metabolic circuits contribute to intestinal injury, we disrupt mitochondrial function in the epithelium by deleting chaperone, heat shock protein 60 (Hsp60
Alternative splicing is a major contributor to transcriptome and proteome diversity in health disease. A plethora of tools have been developed for studying alternative RNA-seq data. Previous benchmarks focused on isoform quantification mapping. They neglected event detection tools, which arguably provide the most detailed insights into process. DICAST offers modular extensible framework analysing integrating eleven splice-aware mapping eight tools. We benchmark all extensively simulated as...
Abstract Alternative splicing is a major contributor to transcriptome and proteome diversity in health disease. A plethora of tools have been developed for studying alternative RNA-seq data. Previous benchmarks focused on isoform quantification mapping. They neglected event detection tools, which arguably provide the most detailed insights into process. DICAST offers modular extensible framework analysis integrating 11 splice-aware mapping eight tools. We benchmark all extensively simulated...
Summary Mitochondrial dysfunction is associated with inflammatory bowel diseases (IBD). To understand how microbial-metabolic circuits contribute to intestinal tissue injury, we disrupt mitochondrial function in the epithelium by deleting heat shock protein 60 (Hsp60 Δ/ΔIEC ). While metabolic perturbation causes self-resolving regeneration disrupted absence of aryl hydrocarbon receptor ;AhR -/- ) or IL-10 ;Il10 leading IBD-like pathology. Injury absent distal colon germ-free (GF) Hsp60 mice,...