Maren Ewers
A5037348579- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Metabolism, Diabetes, and Cancer
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Lipid metabolism and disorders
- Escherichia coli research studies
- Ion Transport and Channel Regulation
- Magnesium in Health and Disease
- Amino Acid Enzymes and Metabolism
- Parathyroid Disorders and Treatments
- Force Microscopy Techniques and Applications
- Calcium Carbonate Crystallization and Inhibition
- Antibiotic Resistance in Bacteria
- Celiac Disease Research and Management
- Gut microbiota and health
- Esophageal Cancer Research and Treatment
- thermodynamics and calorimetric analyses
- Galectins and Cancer Biology
Else Kröner-Fresenius-Stiftung
2017-2024
Technical University of Munich
2019-2023
Fresenius (Germany)
2020-2021
Klinikum rechts der Isar
2017
Intestinal transport and sensing processes their interconnection to metabolism are relevant pathologies such as malabsorption syndromes, inflammatory diseases, obesity type 2 diabetes. Constituting a highly selective barrier, intestinal epithelial cells absorb, metabolize, release nutrients into the circulation, hence serving gatekeeper of nutrient availability metabolic health for whole organism. Next functions, transporters including peptide transporter 1 (PEPT1) involved in absorption...
OBJECTIVES: Premature activation of the digestive protease trypsin within pancreatic parenchyma is a critical factor in pathogenesis pancreatitis. Alterations genes that affect intrapancreatic activity are associated with chronic pancreatitis (CP). Recently, carboxyl ester lipase emerged as trypsin-independent risk gene. Here, we evaluated ( PNLIP ) potential novel susceptibility gene for CP. METHODS: We analyzed all 13 exons 429 nonalcoholic patients CP and 600 control subjects from...
Introduction Chronic pancreatitis (CP) may be caused by oxidative stress. An important source of reactive oxygen species (ROS) is the methylglyoxal-derived formation advanced glycation endproducts (AGE). Methylglyoxal detoxified Glyoxalase I (GLO1). A reduction in GLO1 activity results increased ROS. Single nucleotide polymorphisms (SNPs) have been linked to various inflammatory diseases. Here, we analyzed whether common variants are associated with alcoholic (ACP) and non-alcoholic CP...
Genetic alterations in digestive enzymes have been associated with chronic pancreatitis (CP). Recently, chymotrypsin like elastase 3B (CELA3B) emerged as a novel risk gene. Thus, we evaluated CELA3B two European cohorts CP.We analyzed all 8 exons 550 German non-alcoholic CP (NACP) patients and 241 controls by targeted DNA sequencing. In addition, 6 7 Sanger sequencing the c.129+1G>A variant melting curve analysis 1078 further controls. As replication cohort, investigated up to 243 non-German...
Intestinal fructose uptake is mainly mediated by glucose transporter 5 (GLUT5/SLC2A5). Its closest relative, GLUT7, also expressed in the intestine but does not transport fructose. For rat Glut5, a change of glutamine to glutamic acid at codon 166 (p.Q166E) has been reported alter substrate-binding specificity shifting Glut5-mediated from glucose. Using chimeric proteins GLUT5 and here we identified amino residues that define its substrate specificity. The were NIH-3T3 fibroblasts, their...
The CEL-HYB1 hybrid allele of the carboxyl ester lipase (CEL) gene and its pseudogene (CELP) has been associated with chronic pancreatitis (CP). Recent work indicated that amino acid positions 488 548 in determined pathogenicity. Haplotype Thr488-Ile548 was CP while haplotypes Thr488-Thr548 Ile488-Thr548 were benign. However, functional analysis revealed Thr488 is primary determinant misfolding endoplasmic reticulum (ER) stress. To address this contradiction, we analyzed a cohort from...
ABSTRACT Chronic pancreatitis is a complex disease that involves many factors, both genetic and environmental. Over the past two decades, molecular analysis of five genes are highly expressed in human pancreatic acinar cells, namely PRSS1, PRSS2, SPINK1, CTRC CTRB1 / CTRB2 , has established trypsin-dependent pathway plays key role etiology chronic pancreatitis. Since Ca 2+ deregulation can lead to intracellular trypsin activation experimental acute pancreatitis, we analyzed STIM1 (encoding...