A5047829835- Herpesvirus Infections and Treatments
- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- T-cell and Retrovirus Studies
- Virus-based gene therapy research
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- Viral Infections and Vectors
- Cytomegalovirus and herpesvirus research
- Microbial infections and disease research
- Toxoplasma gondii Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Plant and animal studies
- Viral Infections and Immunology Research
- interferon and immune responses
- Plant Virus Research Studies
- Viral Infections and Outbreaks Research
- RNA and protein synthesis mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Insects and Parasite Interactions
- Mosquito-borne diseases and control
- Insect and Pesticide Research
Health Sciences University of Hokkaido
2011-2022
American Museum of Natural History
2010
Hokkaido University
1996-2005
China Agricultural University
2003
University of Oxford
1998
Tokyo University of Agriculture and Technology
1986-1994
St. Jude Children's Research Hospital
1989
Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. However, less than 5% BLV-infected cattle will develop lymphoma, suggesting that, in addition to viral infection, host genetic polymorphisms might play a role disease susceptibility. leukocyte antigen (BoLA)-DRB3 highly polymorphic gene associated with BLV proviral load (PVL) Due fact that PVL positively progression, it believed controlling can prevent lymphoma development. Thus, many studies have focused on...
Abstract The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, 2019 2020, respectively. YEZV phylogenetically grouped Sulina detected Ixodes ricinus ticks Romania. infection has been...
ABSTRACT Ebola virus causes severe hemorrhagic fever in primates, resulting mortality rates of up to 100%, yet there are no satisfactory biologic explanations for this extreme virulence. Here we show that antisera produced by DNA immunization with a plasmid encoding the surface glycoprotein (GP) Zaire strain enhances infectivity vesicular stomatitis pseudotyped GP. Substantially weaker enhancement was observed antiserum GP Reston strain, which is much less pathogenic humans than and Sudan...
ABSTRACT In the influenza H5N1 virus incident in Hong Kong 1997, viruses that are closely related to initially isolated a severe outbreak of avian chickens were from humans, signaling possibility an incipient pandemic. However, it was not possible prepare vaccine against conventional embryonated egg system because lethality for chicken embryos and high level biosafety therefore required production. Alternative approaches, including avirulent H5N4 migratory duck as surrogate virus,...
To determine the site of latent infection canine herpesvirus (CHV), tissues from dogs convalescent acute with CHV were examined for presence viral genome DNA by nested polymerase chain reaction. was detected in trigeminal ganglia and retropharyngeal lymph nodes. In situ hybridization study revealed that persisted nuclei ganglionic neurons lymphocytes.
Summary. In this study, 520 serum samples from Yezo‐deer in the Hidaka district, Hokkaido, Japan were examined by enzyme‐linked immunosorbent assay to investigate whether animals infected with hepatitis E virus (HEV). The distribution of optical density values showed a bimodal pattern and 181 (34.8%) deemed be antibody‐positive against HEV. At least five (2.8%) positive sera gave specific bands Western blot analysis. An age‐dependent increase prevalence antibodies was found among animals....
A highly sensitive immuno-PCR method specific for the detection of antigens and antibodies to bovine herpesvirus 1 was established. This assay attained a high sensitivity up 10(7.0) times higher than that enzyme-linked immunosorbent (ELISA) or PCR antigen 10(5.0) ELISA antibody detection.
Glycoprotein B (gB) is the most conserved glycoprotein of herpesviruses and plays important roles in virus infectivity. Two intervening heptad repeat (HR) sequences were found C-terminal half all herpesvirus gBs analysed. A synthetic peptide derived from HR region (aa 477-510) bovine type 1 (BoHV-1) gB was studied for its ability to inhibit replication. The interfered with cell-to-cell spread consistently inhibited replication BoHV-1, a 50 % effective concentration value (EC(50)) 5 microM....
Glycoprotein B (gB) is the most conserved glycoprotein among herpesviruses and it plays important roles in virus infectivity. In herpesviruses, including pseudorabies (PRV), gB cleaved by a cellular protease into two disulfide-linked subunits. present study, I found that PRV generated human colon carcinoma LoVo cells, which lack ubiquitous furin, remained uncleaved form replicated these cells without cell fusion. The was converted its subunits after furin digestion. also Madin–Darby bovine...