Giulia Martina Cavestro
A5032074249- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Gastroesophageal reflux and treatments
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Neuroendocrine Tumor Research Advances
- Eosinophilic Esophagitis
- Diverticular Disease and Complications
- Multiple and Secondary Primary Cancers
- IgG4-Related and Inflammatory Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Diabetes and associated disorders
- Celiac Disease Research and Management
- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Digestive system and related health
- Colorectal Cancer Treatments and Studies
- Liver Diseases and Immunity
Vita-Salute San Raffaele University
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2014-2025
IRCCS Ospedale San Raffaele
2007-2023
The Ohio State University
2023
Norwegian Cancer Society
2023
LMU Klinikum
2023
Rabin Medical Center
2023
World Water Watch
2023
Institute of Experimental Endocrinology of the Slovak Academy of Sciences
2023
Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch syndrome result in different but imprecisely known cancer risks. This study aimed to provide age organ-specific risks according gene gender determine survival after cancer.We conducted an international, multicenter prospective observational using independent test validation cohorts of carriers class 4 or 5 variants. After the were merged providing 6350 participants 51,646 follow-up years.There 1808 prospectively observed...
Patients with early-onset colorectal cancer (eoCRC) are managed according to guidelines that not age-specific. A multidisciplinary international group (DIRECt), composed of 69 experts, was convened develop the first evidence-based consensus recommendations for eoCRC.
<h3>Objective</h3> Several genetic risk factors have been identified for non-alcoholic chronic pancreatitis (NACP). A genome-wide association study reported an of (CP) with variants in <i>PRSS1</i>–<i>PRSS2</i> (<i>rs10273639</i>; near the gene encoding cationic trypsinogen) and <i>CLDN2</i>–<i>MORC4</i> loci (<i>rs7057398</i> <i>RIPPLY1</i> <i>rs12688220</i> <i>MORC4</i>). We aimed to refine these findings a large European cohort. <h3>Design</h3> studied 3062 patients alcohol-related CP...
Objective Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic (CP) poorly characterised. To identify risk genes for CP and evaluate their relevance in non-alcoholic CP, we performed genome-wide association study functional characterisation new locus. Design 1959 European patients population-based controls from the KORA, LIFE INCIPE studies...
// Mingfeng Zhang 1 , Zhaoming Wang 2,3,100 Ofure Obazee 4 Jinping Jia Erica J. Childs 5 Jason Hoskins Gisella Figlioli Evelina Mocci Irene Collins Charles C. Chung 2,3 Christopher Hautman Alan A. Arslan 6,7,8 Laura Beane-Freeman 2 Paige M. Bracci 9 Julie Buring 10,11 Eric Duell 12 Steven Gallinger 13 Graham G. Giles 14,15,16 Gary E. Goodman 17 Phyllis 18 Aruna Kamineni 19 Laurence N. Kolonel 20 Matthew H. Kulke 21 Núria Malats 22 Sara Olson 23 Howard D. Sesso 24,10,11 Kala...
Early-onset pancreatic cancer (EOPC) represents 5-10% of all ductal adenocarcinoma (PDAC) cases, and the etiology this form is poorly understood. It not clear if established PDAC risk factors have same relevance for younger patients. This study aims to identify genetic non-genetic specific EOPC.A genome-wide association was performed, analysing 912 EOPC cases 10 222 controls, divided into discovery replication phases. Furthermore, associations between a polygenic score (PRS), smoking,...
Abstract Background: Curcumin is the principal element of turmeric powder extracted from root Curcuma longa . Studies on curcumin have demonstrated some anti‐ Helicobacter pylori activity as well immunomodulating properties. N‐acetylcysteine and lactoferrin with their respective mucolytic antibacterial activities might also be effective in H. eradication therapy. Aim: To determine if a 7‐day non‐antibiotic therapy comprised curcumin, lactoferrin, N‐acetylcysteine, pantoprazole was for...
Background Most cases of pancreatic ductal adenocarcinoma (PDAC) are asymptomatic in early stages, and the disease is typically diagnosed advanced phases, resulting very high mortality. Tools to identify individuals at risk developing PDAC would be useful improve chances detection. Objective We generated a polygenic score (PRS) for prediction, combining effect known SNPs, carried out an exploratory analysis multifactorial score. Methods tested associations individual SNPs on up 2851 4810...