Narcis Zarnescu
A5047054037- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Appendicitis Diagnosis and Management
- Lipid metabolism and disorders
- Abdominal Surgery and Complications
- Colorectal Cancer Treatments and Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Sarcoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Diabetes and associated disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Health and Biochemistry
- Colorectal Cancer Screening and Detection
- Ultrasound in Clinical Applications
- Skin and Cellular Biology Research
- Bone Tumor Diagnosis and Treatments
- Muscle and Compartmental Disorders
- Intraperitoneal and Appendiceal Malignancies
- Hospital Admissions and Outcomes
Carol Davila University of Medicine and Pharmacy
2015-2025
Clinical Emergency Hospital Bucharest
2005-2025
Collaborative Group (United States)
2023
University of Pittsburgh
2008-2012
University of Pittsburgh Medical Center
2008
Klinikum rechts der Isar
2006
Friedrich-Alexander-Universität Erlangen-Nürnberg
2006
Charité - Universitätsmedizin Berlin
2006
Abstract Background Persistent organ failure (POF) is the strongest determinant of mortality in acute pancreatitis (AP). There a paucity data regarding impact different POF attributes on and role characteristics systemic inflammatory response syndrome (SIRS) risk developing POF. Objective We aimed to assess association dynamic features with SIRS Methods studied 1544 AP subjects prospectively enrolled at 22 international centers (APPRENTICE consortium). First, we estimated onset, duration,...
We have established a multicenter international consortium to better understand the natural history of acute pancreatitis (AP) worldwide and develop platform for future randomized clinical trials.The AP patient registry examine novel therapies in experience (APPRENTICE) was formed July 2014. Detailed web-based questionnaires were then developed prospectively capture information on demographics, etiology, history, comorbidities, risk factors, severity biomarkers, indices, health-care...
Abstract Background Multisystem organ failure (MSOF) is the most important determinant of mortality in acute pancreatitis (AP). Obesity and alcoholic etiology have been examined as potential risk factors for MSOF, but prior studies not adequately elucidated their independent effects on MSOF. Objective We aimed to determine adjusted body mass index (BMI) MSOF subjects with AP. Methods A prospective observational study 22 centers from 10 countries was conducted. Patients admitted an APPRENTICE...
The identification of high-risk patients in the early stages infected pancreatic necrosis (IPN) is critical, because it could help clinicians to adopt more effective management strategies. We conducted a post hoc analysis MANCTRA-1 international study assess association between clinical risk factors and mortality among adult with IPN. Univariable multivariable logistic regression models were used identify prognostic mortality. identified 247 consecutive IPN hospitalised January 2019 December...
(1) Introduction: One of the most common causes acute pancreatitis is cholelithiasis, which considered to be associated with female sex, older age, and recurrence. Our aim was define a group patients B-AP facilitate their diagnosis management, while more judiciously using medical resources. (2) Materials Methods: This retrospective, large cohort study, conducted by extracting data from BUC-API registry, consisted 1855 cases between 1 June 2015 April 2022. Each admission same patient separate...
Background: The optimal management of patients with acute pancreatitis is directly related to the early detection mild, moderate, or severe forms disease, which remains a continuous challenge despite availability various severity scores. aim this study was identify prognostic factors highest predictive value specific local and elaborate score cases. Materials Methods: A retrospective observational cohort included 172 diagnosed pancreatitis. Personal, clinical, laboratory, imaging their...
INTRODUCTION: Recent pilot trials in acute pancreatitis (AP) found that lactated ringers (LR) usage may result decreased risk of moderately severe/severe AP compared with normal saline, but their small sample sizes limit statistical power. We investigated whether LR is associated improved outcomes an international multicenter prospective study. METHODS: Patients directly admitted the diagnosis were prospectively enrolled at 22 sites between 2015 and 2018. Demographics, fluid administration,...
Inability to advance an oral diet, or feeding intolerance, is a common complication in patients with acute pancreatitis associated worse clinical outcomes. The factors related intolerance are not well studied.We aimed determine the incidence and risk of pancreatitis.Patients were prospectively enrolled Acute Pancreatitis Patient Registry Examine Novel Therapies Clinical Experience, international registry, between 2015 2018. Oral was defined as worsening abdominal pain and/or vomiting after...
Objectives Acute pancreatitis (AP) is a sudden onset, rapidly evolving inflammatory response with systemic inflammation and multiorgan failure (MOF) in subset of patients. New highly accurate clinical decision support tools are needed to allow local doctors provide expert care. Methods Ariel Dynamic Pancreatitis Tracker (ADAPT) digital tool guide physicians ordering standard tests, evaluate test results model progression using available data, propose emergent therapies. The accuracy the...