A5046911814- Forensic and Genetic Research
- Forensic Anthropology and Bioarchaeology Studies
- Archaeology and ancient environmental studies
- Paleopathology and ancient diseases
- Genetic diversity and population structure
- Race, Genetics, and Society
- Yersinia bacterium, plague, ectoparasites research
- Isotope Analysis in Ecology
- Pleistocene-Era Hominins and Archaeology
- Genetic Associations and Epidemiology
- Pacific and Southeast Asian Studies
- Identification and Quantification in Food
- Ancient Mediterranean Archaeology and History
- Digestive system and related health
- Glycosylation and Glycoproteins Research
- Language and cultural evolution
- T-cell and B-cell Immunology
- Archaeological and Geological Studies
- dental development and anomalies
- Erythrocyte Function and Pathophysiology
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Celiac Disease Research and Management
- Blood groups and transfusion
University of Rome Tor Vergata
2015-2024
United States Nuclear Regulatory Commission
2014
Klinikum rechts der Isar
2006
Friedrich-Alexander-Universität Erlangen-Nürnberg
2006
Charité - Universitätsmedizin Berlin
2006
University of Messina
2004
Osaka Medical and Pharmaceutical University
1997
University of Turin
1996
University of Cambridge
1993
Sapienza University of Rome
1983
Native Americans derive from a small number of Asian founders who likely arrived to the Americas via Beringia. However, additional details about intial colonization remain unclear. To investigate pioneering phase in we analyzed total 623 complete mtDNAs and Asia, including 20 new seven Asia. This sequence data was used direct high-resolution genotyping American 26 populations. Here describe more genetic diversity within founder population than previously reported. The newly resolved...
Abstract Mitochondrial and Y‐chromosome DNA were analyzed from 10,300‐year‐old human remains excavated On Your Knees Cave on Prince of Wales Island, Alaska (Site 49‐PET‐408). This individual's mitochondrial (mtDNA) represents the founder haplotype an additional subhaplogroup haplogroup D that was brought to Americas, demonstrating widely held assumptions about genetic composition earliest Americans are incorrect. The amount diversity has accumulated in over past 10,300 years suggests...
Abstract Here we report on a stable isotope palaeodietary study of Imperial Roman population interred near the port Velia in Southern Italy during 1st and 2nd centuries AD. Carbon nitrogen analyses were performed collagen extracted from 117 adult humans as well range fauna to reconstruct individual dietary histories. For majority individuals, found that data consistent with diet high cereals, relatively modest contributions meat only minor marine fish. However, substantial isotopic variation...
The animal and plant biodiversity of the Italian territory is known to be one richest in Mediterranean basin Europe as a whole, but does genetic diversity extant human populations show comparable pattern? According number studies, structure retains signatures complex peopling processes which took place from Paleolithic modern era. Although observed patterns highlight remarkable degree heterogeneity, they do not, however, take into account an important source variation. In fact, Italy home...
Summary A difference in the prevalence of venous thromboembolism (TE) major human groups has been described and an uneven distribution FV Leiden mutation over world recently reported. We investigated 584 apparently healthy sub#jects mostly from populations different those previously investi#gated: 170 Europeans (Spanish, Italians), 101 sub-saharan Africans (Fon, Bariba, Berba, Dendi), 115 Asians (Indonesians, Chinese, Tharus), 57 Amerindians (Cayapa), 84 Afroamericans (Rio Cayapa, Viche),...
Abstract: In order to understand the forces governing evolution of genetic diversity in HLA‐DP molecule, polymerase chain reaction (PCR)‐based methods were used characterize variation at DPA1 and DPB1 loci encoding this heterodimer on 2,807 chromosomes from 15 different populations including individuals African, Asian, Amerindian, Indian European origin. These ethnically diverse samples represent a variety population substructures include small, isolated as well larger, presumably admixed...
Extensive European and African admixture coupled with loss of Amerindian lineages makes the reconstruction pre-Columbian history Native Americans based on present-day genomes extremely challenging. Still open questions remain about dispersals that occurred throughout continent after initial peopling from Beringia, especially concerning number dynamics diffusions into South America. Indeed, if environmental historical factors contributed to shape distinct gene pools in Andes Amazonia, origins...
Huntington's disease is caused by a pathologically long (>35) CAG repeat located in the first exon of Huntingtin gene (HTT). While expanded repeats are focus extensive investigations, non-pathogenic tracts protein-coding genes less well characterized. Here, we investigated function and evolution physiological tract HTT gene. We show that poly-glutamine (polyQ) encoded CAGs huntingtin protein (HTT) under purifying selection subjected to stronger selective pressures than CAG-encoded polyQ...
Genetic variation at NAT2 has been long recognized as the cause of differential ability to metabolize a wide variety drugs therapeutic use. Here, we explore pattern genetic in 12 human populations that significantly extend geographic range and resolution previous surveys, test hypothesis different dietary regimens lifestyles may explain inter-population differences variation.The entire coding region was resequenced 98 subjects six polymorphic positions were genotyped 150 additional subjects....
The Tuareg of the Fezzan region (Libya) are characterized by an extremely high frequency (61%) haplogroup H1, a mitochondrial DNA (mtDNA) that is common in all Western European populations. To define how and when H1 spread from Europe to North Africa up Central Sahara, Fezzan, we investigated complete genomes eleven Libyan belonging H1. Coalescence time estimates suggest arrival mtDNAs at about 8,000–9,000 years ago, while phylogenetic analyses reveal three novel branches, termed H1v, H1w...
Abstract Stable isotope analysis of human remains has been used to address long‐standing debates regarding the speed and degree which introduction farming transformed diet. In Europe, this debate centered on northern Atlantic regions with much less attention devoted arrival across Mediterranean. This study presents carbon nitrogen stable analyses collagen from 19 37 faunal eight sites in Apulia Marche south‐eastern central Italy, dating early phases agricultural adoption during first half...