A5090146617- Forensic and Genetic Research
- Genetic diversity and population structure
- Molecular Biology Techniques and Applications
- Adipose Tissue and Metabolism
- T-cell and B-cell Immunology
- Peroxisome Proliferator-Activated Receptors
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Electrical and Thermal Properties of Materials
- Race, Genetics, and Society
- Metabolism, Diabetes, and Cancer
- Angiogenesis and VEGF in Cancer
- Sexual Differentiation and Disorders
- Identification and Quantification in Food
- Helicobacter pylori-related gastroenterology studies
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- Erythrocyte Function and Pathophysiology
- Chromosomal and Genetic Variations
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA Interference and Gene Delivery
- Immunodeficiency and Autoimmune Disorders
Wroclaw Medical University
2016-2025
Versar (United States)
2017
Wroclaw Research Centre EIT+ (Poland)
2015
Wrocław University of Environmental and Life Sciences
2012
University of Wrocław
2003-2008
Institute of Forensic Science
2000
Niepubliczna Wyższa Szkoła Medyczna
1991
Medical University of Lublin
1978
Gdańsk Medical University
1977
Nonrecombining Y-chromosomal microsatellites (Y-STRs) are widely used to infer population histories, discover genealogical relationships, and identify males for criminal justice purposes. Although a key requirement their application is reliable mutability knowledge, empirical data only available small number of Y-STRs thus far. To rectify this, we analyzed large 186 Y-STR markers in nearly 2000 DNA-confirmed father-son pairs, covering an overall 352,999 meiotic transfers. Following...
Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used testing close paternal relationships among individuals and populations, male lineage identification. However, even the widely 17-loci Yfiler set cannot resolve populations completely. Here, 52 centers generated quality-controlled data 13 rapidly mutating (RM) Y-STRs in 14,644 related unrelated males from 111 worldwide populations. Strikingly, >99% 12,272 were completely individualized....
The Y-chromosomal short tandem repeat (Y-STR) polymorphisms included in the AmpFlSTR Yfiler polymerase chain reaction amplification kit have become widely used for forensic and evolutionary applications where a reliable knowledge on mutation properties is necessary correct data interpretation. Therefore, we investigated 17 Y-STRs 1,730-1,764 DNA-confirmed father-son pairs per locus found 84 sequence-confirmed mutations among 29,792 meiotic transfers covered. Of mutations, 83 (98.8%) were...
To shed more light on the processes leading to crystallization of a Slavic identity, we investigated variability complete mitochondrial genomes belonging haplogroups H5 and H6 (63 mtDNA genomes) from populations Eastern Western Slavs, including new samples Poles, Ukrainians Czechs presented here. Molecular dating implies formation approximately 11.5–16 thousand years ago (kya) in areas southern Europe. Within ancient haplogroup H6, dated at around 15–28 kya, there is subhaplogroup H6c, which...
Abstract Background Adipogenesis is the process of adipocytes formation from unspecialized progenitor cells called mesenchymal stromal cells. Numerous mechanisms including epigenetic regulation modulate correct progress this process. Dietary exposures occurring over a specific period time might cause long-lasting and even permanent changes in gene expression regulated by mechanisms. For that reason, we investigated adipogenesis 3 T3-L1 with excess saturated monounsaturated fatty acids their...
Short tandem repeat polymorphisms on the male-specific part of human Y-chromosome (Y-STRs) are valuable tools in many areas genetics. Although their paternal inheritance and moderate mutation rate (~10−3 mutations per marker meiosis) allow detecting relationships, they typically fail to separate male relatives. Previously, we identified 13 Y-STR markers with untypically high rates (>10−2), termed rapidly mutating (RM) Y-STRs, showed that improved relative differentiation over standard...
Obesity is a major health problem in highly industrialized countries. High-fat diet (HFD) one of the most common causes obesity and obesity-related disorders. There are considerable differences between fat depots corresponding risks metabolic We investigated various effects an excess fatty acids (palmitic 16:0, stearic 18:0, oleic 18:1n−9) on adipogenesis subcutaneous- visceral-derived mesenchymal stem cells (MSCs) phenotypes mature adipocytes. MSCs white adipose tissue were acquired from...
One of the central dogmas Catholic Church is belief in Eucharistic presence Jesus Christ, which requires no scientific confirmation because it concerns a supernatural reality. Since early Middle Ages, however, instances have been recorded improperly referred to as miracles, believers consider eyewitness testimony real transubstantiation. Changes structure, number, or an unexpected bloody red colour Host were often regarded phenomena, but officials themselves, aware possibility biological...
Insulin acts by binding with a specific receptor called an insulin (INSR), ending up glucose transporter activation and uptake. resistance (IR) is state when the physiological amount of not sufficient to evoke proper action, i.e., Epigenetic modifications associated obesity IR are some main mechanisms leading pathogenesis. The mesenchymal stem cells adipose tissue (subcutaneous (SAT) visceral (VAT)) were collected during abdominal surgery. was induced ex vivo palmitic acid. DNA methylation...
Insulin resistance (IR) is a state when the physiological amount of insulin not sufficient to evoke proper action, that is, glucose uptake. Numerous conditions lead IR, including epigenetic components. Epigenetic modifications, associated with obesity and IR are one main mechanisms leading pathogenesis. The adipose tissue samples (subcutaneous (SAT) visceral (VAT)) were collected during abdominal surgery from 40 patients wide range BMI, age, ratios (F = 9, M 31). was induced in 3T3-L1...