Tadeusz Dobosz

ORCID: 0000-0003-0413-9109
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About
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Research Areas
  • Forensic and Genetic Research
  • Genetic diversity and population structure
  • Molecular Biology Techniques and Applications
  • Adipose Tissue and Metabolism
  • T-cell and B-cell Immunology
  • Peroxisome Proliferator-Activated Receptors
  • Diabetes and associated disorders
  • Adipokines, Inflammation, and Metabolic Diseases
  • Epigenetics and DNA Methylation
  • Electrical and Thermal Properties of Materials
  • Race, Genetics, and Society
  • Metabolism, Diabetes, and Cancer
  • Angiogenesis and VEGF in Cancer
  • Sexual Differentiation and Disorders
  • Identification and Quantification in Food
  • Helicobacter pylori-related gastroenterology studies
  • Metabolism and Genetic Disorders
  • Diet and metabolism studies
  • Nutrition, Genetics, and Disease
  • Genetic Associations and Epidemiology
  • Erythrocyte Function and Pathophysiology
  • Chromosomal and Genetic Variations
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • RNA Interference and Gene Delivery
  • Immunodeficiency and Autoimmune Disorders

Wroclaw Medical University
2016-2025

Versar (United States)
2017

Wroclaw Research Centre EIT+ (Poland)
2015

Wrocław University of Environmental and Life Sciences
2012

University of Wrocław
2003-2008

Institute of Forensic Science
2000

Niepubliczna Wyższa Szkoła Medyczna
1991

Medical University of Lublin
1978

Gdańsk Medical University
1977

Nonrecombining Y-chromosomal microsatellites (Y-STRs) are widely used to infer population histories, discover genealogical relationships, and identify males for criminal justice purposes. Although a key requirement their application is reliable mutability knowledge, empirical data only available small number of Y-STRs thus far. To rectify this, we analyzed large 186 Y-STR markers in nearly 2000 DNA-confirmed father-son pairs, covering an overall 352,999 meiotic transfers. Following...

10.1016/j.ajhg.2010.08.006 article EN cc-by-nc-nd The American Journal of Human Genetics 2010-09-01
Josephine Purps Sabine Siegert Sascha Willuweit Marion Nagy Cı́ntia Alves and 95 more Renato Salazar Sheila M.T. Angustia Lorna H. Santos Katja Anslinger Birgit Bayer Qasim Ayub Wei Wei Yali Xue Chris Tyler‐Smith Miriam Baeta Begoña Martínez‐Jarreta Balázs Egyed Beate Balitzki Sibylle Tschumi David Ballard Denise Syndercombe Court Xinia Barrantes Gerhard P. Bassler Tina Wiest Burkhard Berger Harald Niederstätter Walther Parson Carey Davis Bruce Budowle Haran Burri U. V. Borer Christoph Koller Elizeu Fagundes de Carvalho Patricia M. Domingues Wafaa Takash Chamoun Michael D. Coble Carolyn R. Hill Daniel Corach Mariela Caputo María Eugenia D’Amato Sean Davison Ronny Decorte Maarten Larmuseau Claudio Ottoni Olga Rickards Di Lu Jiang Cheng-tao Tadeusz Dobosz Anna Jonkisz William E. Frank Ivana Furač Christian Gehrig Vincent Castella Branka Gršković Cordula Haas Jana Wobst Gavrilo Hadzic Katja Drobnič Katsuya Honda Yiping Hou Di Zhou Yan Li Shengping Hu Shenglan Chen Uta-Dorothee Immel Rüdiger Lessig Zlatko Jakovski Tanja Ilievska Anja E. Klann Cristina García Peter de Knijff Thirsa Kraaijenbrink A. Kondili P. Miniati Maria Vouropoulou Lejla Kovačević Damir Marjanović Iris Lindner Issam Mansour Mouayyad Al-Azem Ansar El Andari Miguel Marino Sandra Furfuro Laura Locarno Pablo Martı́n Gracia Luque Antonio Alonso Luís Souto Miranda Helena Moreira Natsuko Mizuno Yasuki Iwashima Rodrigo S. Moura Neto T.L.S. Nogueira Rosane Silva Marina Nastainczyk-Wulf Jeanett Edelmann Michael M. Kohl Shengjie Nie Xianping Wang Baowen Cheng

10.1016/j.fsigen.2014.04.008 article EN cc-by Forensic Science International Genetics 2014-04-28
Kaye N. Ballantyne Arwin Ralf Rachid Aboukhalid Niaz M. Achakzai Maria João Anjos and 95 more Qasim Ayub Jože Balažič Jack Ballantyne David Ballard Burkhard Berger Cecilia Bobillo Mehdi Bouabdellah Haran Burri Tomas Capal Stefano Caratti Jorge Cárdenas François Cartault Elizeu Fagundes de Carvalho M. Carvalho Baowen Cheng Michael D. Coble David Comas Daniel Corach María Eugenia D’Amato Sean Davison Peter de Knijff Maria Corazon A. De Ungria Ronny Decorte Tadeusz Dobosz Berit Myhre Dupuy Samir Elmrghni Mateusz Gliwiński Sara C. Gomes Laurens J.W. Grol Cordula Haas Erin Hanson Jürgen Henke Lotte Henke Fabiola Herrera-Rodríguez Carolyn R. Hill Gunilla Holmlund Katsuya Honda Uta‐Dorothee Immel Shota Inokuchi Mark A. Jobling Mahmoud Kaddura Jong S. Kim Soon H Kim Wook Kim Turi King Eva Klausriegler Daniel Kling Lejla Kovačević Leda Kovatsi Paweł Krajewski С. А. Кравченко Maarten Larmuseau Eun Young Lee Р. Лессиг Л. А. Лившиц Damir Marjanović Marek Minárik Natsuko Mizuno Helena Moreira Niels Morling Meeta Mukherjee Patrick Munier Javaregowda Nagaraju Franz Neuhuber Shengjie Nie Premlaphat Nilasitsataporn Takeki Nishi Hye Hyun Oh Jill K. Olofsson Valerio Onofri Jukka U. Palo Horolma Pamjav Walther Parson Michal Petlach Christopher Phillips Rafał Płoski Samayamantri P. R. Prasad Dragan Primorac Gludhug A. Purnomo Josephine Purps Héctor Rangel‐Villalobos Krzysztof Rębała Budsaba Rerkamnuaychoke Danel Rey González Carlo Robino Lutz Roewer Alexandra Rosa Antti Sajantila Andrea Sala Jazelyn M. Salvador Paula Sanz Cornelia Schmitt Añil Sharma Silva Da Kyoung‐Jin Shin

Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used testing close paternal relationships among individuals and populations, male lineage identification. However, even the widely 17-loci Yfiler set cannot resolve populations completely. Here, 52 centers generated quality-controlled data 13 rapidly mutating (RM) Y-STRs in 14,644 related unrelated males from 111 worldwide populations. Strikingly, >99% 12,272 were completely individualized....

10.1002/humu.22599 article EN Human Mutation 2014-06-11

The Y-chromosomal short tandem repeat (Y-STR) polymorphisms included in the AmpFlSTR Yfiler polymerase chain reaction amplification kit have become widely used for forensic and evolutionary applications where a reliable knowledge on mutation properties is necessary correct data interpretation. Therefore, we investigated 17 Y-STRs 1,730-1,764 DNA-confirmed father-son pairs per locus found 84 sequence-confirmed mutations among 29,792 meiotic transfers covered. Of mutations, 83 (98.8%) were...

10.1007/s00414-009-0342-y article EN cc-by-nc International Journal of Legal Medicine 2009-03-25

To shed more light on the processes leading to crystallization of a Slavic identity, we investigated variability complete mitochondrial genomes belonging haplogroups H5 and H6 (63 mtDNA genomes) from populations Eastern Western Slavs, including new samples Poles, Ukrainians Czechs presented here. Molecular dating implies formation approximately 11.5–16 thousand years ago (kya) in areas southern Europe. Within ancient haplogroup H6, dated at around 15–28 kya, there is subhaplogroup H6c, which...

10.1371/journal.pone.0054360 article EN cc-by PLoS ONE 2013-01-14

Abstract Background Adipogenesis is the process of adipocytes formation from unspecialized progenitor cells called mesenchymal stromal cells. Numerous mechanisms including epigenetic regulation modulate correct progress this process. Dietary exposures occurring over a specific period time might cause long-lasting and even permanent changes in gene expression regulated by mechanisms. For that reason, we investigated adipogenesis 3 T3-L1 with excess saturated monounsaturated fatty acids their...

10.1186/s12944-019-1173-6 article EN cc-by Lipids in Health and Disease 2019-12-01

Short tandem repeat polymorphisms on the male-specific part of human Y-chromosome (Y-STRs) are valuable tools in many areas genetics. Although their paternal inheritance and moderate mutation rate (~10−3 mutations per marker meiosis) allow detecting relationships, they typically fail to separate male relatives. Previously, we identified 13 Y-STR markers with untypically high rates (>10−2), termed rapidly mutating (RM) Y-STRs, showed that improved relative differentiation over standard...

10.1002/humu.24068 article EN Human Mutation 2020-06-24

Obesity is a major health problem in highly industrialized countries. High-fat diet (HFD) one of the most common causes obesity and obesity-related disorders. There are considerable differences between fat depots corresponding risks metabolic We investigated various effects an excess fatty acids (palmitic 16:0, stearic 18:0, oleic 18:1n−9) on adipogenesis subcutaneous- visceral-derived mesenchymal stem cells (MSCs) phenotypes mature adipocytes. MSCs white adipose tissue were acquired from...

10.3390/genes11091092 article EN Genes 2020-09-18

One of the central dogmas Catholic Church is belief in Eucharistic presence Jesus Christ, which requires no scientific confirmation because it concerns a supernatural reality. Since early Middle Ages, however, instances have been recorded improperly referred to as miracles, believers consider eyewitness testimony real transubstantiation. Changes structure, number, or an unexpected bloody red colour Host were often regarded phenomena, but officials themselves, aware possibility biological...

10.1007/s00253-025-13439-9 article EN cc-by-nc-nd Applied Microbiology and Biotechnology 2025-03-05

Insulin acts by binding with a specific receptor called an insulin (INSR), ending up glucose transporter activation and uptake. resistance (IR) is state when the physiological amount of not sufficient to evoke proper action, i.e., Epigenetic modifications associated obesity IR are some main mechanisms leading pathogenesis. The mesenchymal stem cells adipose tissue (subcutaneous (SAT) visceral (VAT)) were collected during abdominal surgery. was induced ex vivo palmitic acid. DNA methylation...

10.3390/genes12060889 article EN Genes 2021-06-09

Insulin resistance (IR) is a state when the physiological amount of insulin not sufficient to evoke proper action, that is, glucose uptake. Numerous conditions lead IR, including epigenetic components. Epigenetic modifications, associated with obesity and IR are one main mechanisms leading pathogenesis. The adipose tissue samples (subcutaneous (SAT) visceral (VAT)) were collected during abdominal surgery from 40 patients wide range BMI, age, ratios (F = 9, M 31). was induced in 3T3-L1...

10.1016/j.biocel.2021.106031 article EN cc-by-nc-nd The International Journal of Biochemistry & Cell Biology 2021-06-25
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