A5070098215- Epigenetics and DNA Methylation
- Forensic Toxicology and Drug Analysis
- Forensic and Genetic Research
- melanin and skin pigmentation
- Cannabis and Cannabinoid Research
- Carcinogens and Genotoxicity Assessment
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Hormonal and reproductive studies
- Treatment of Major Depression
- Alcohol Consumption and Health Effects
- Magnesium in Health and Disease
- Trace Elements in Health
- Race, Genetics, and Society
- Effects and risks of endocrine disrupting chemicals
- Forensic Anthropology and Bioarchaeology Studies
- Genetic diversity and population structure
- Pharmacogenetics and Drug Metabolism
- Folate and B Vitamins Research
- Molecular Biology Techniques and Applications
- Functional Brain Connectivity Studies
- Heavy Metal Exposure and Toxicity
- Opioid Use Disorder Treatment
- Prenatal Substance Exposure Effects
- Pharmacological Effects and Assays
Aristotle University of Thessaloniki
2016-2025
Central Forensic Science Laboratory
2012
Athens Medical Center
2000
Recently, the field of predicting phenotypes externally visible characteristics (EVCs) from DNA genotypes with final aim concentrating police investigations to find persons completely unknown investigating authorities, also referred as Forensic Phenotyping (FDP), has started become established in forensic biology. We previously developed and forensically validated IrisPlex system for accurate prediction blue brown eye colour DNA, recently showed that all major hair categories are predictable...
Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used testing close paternal relationships among individuals and populations, male lineage identification. However, even the widely 17-loci Yfiler set cannot resolve populations completely. Here, 52 centers generated quality-controlled data 13 rapidly mutating (RM) Y-STRs in 14,644 related unrelated males from 111 worldwide populations. Strikingly, >99% 12,272 were completely individualized....
Human skin colour is highly heritable and externally visible with relevance in medical, forensic, anthropological genetics. Although eye hair can already be predicted high accuracies from small sets of carefully selected DNA markers, knowledge about the genetic predictability limited. Here, we investigate predictive value 77 single-nucleotide polymorphisms (SNPs) 37 loci previously associated human pigmentation using 2025 individuals 31 global populations. We identified a minimal set 36...
Telomeres are nucleotide tandem repeats located at the tip of eukaryotic chromosomes that maintain genomic integrity. The gradual shortening telomeres leads to cellular senescence and apoptosis, a key mechanism aging age‑related chronic diseases. Epigenetic factors, such as nutrition, exercise tobacco can affect rate which shorten modify risk developing In this study, we evaluated effects combination nutraceutical supplements (NS) on telomere length (TL) in healthy volunteers with no medical...
Gliomas are the most common primary brain tumors in adults. They generally very resistant to treatment and therefore associated with negative outcomes. MicroRNAs (miRNAs) small, non-coding RNA molecules that affect many cellular processes by regulating gene expression and, post-transcriptionally, translation of mRNAs. MiRNA-21 has been consistently shown be upregulated glioma research it is involved a wide variety biological pathways, promoting tumor cell survival invasiveness. Furthermore,...
Carbon monoxide (CO) poisoning causes cardiotoxicity and so far, no definite antidote has been proposed to overcome CO-induced adverse outcomes. Hesperidin, a citrus flavonoid, shown cardio-protective effects in cardiac ischemia/reperfusion models. This study investigated the protective of hesperidin against injury. To induce CO poisoning, rats were exposed at 3000 ppm for 60 min. On exposure day four following days, (at three different doses 25, 50, 100 mg/kg/day) was administered...
One of the principle symptoms lead poisoning is development neurological disorders. Neuronal response closely related to DNA methylation changes. Aim. In this study, we estimated p16 in nine individuals exposed using methylation-specific polymerase chain reaction followed by analysis methylated cytosine content product thermal denaturation.We found that, based on blood concentration, lead-exposed were divided into two groups. Among highly (blood Pb(2+) concentration = 51-100 microg/dL),...
Acute alcohol intake is known to enhance inhibition through facilitation of GABAA receptors, which are present in 40% the synapses all over brain. Evidence suggests that enhanced GABAergic transmission leads increased large-scale brain connectivity. Our hypothesis acute would increase functional connectivity human resting-state network (RSN). To test our hypothesis, electroencephalographic (EEG) measurements were recorded from healthy social drinkers at rest, during eyes-open and eyes-closed...