A5001203540- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Dementia and Cognitive Impairment Research
- Epilepsy research and treatment
- Intracranial Aneurysms: Treatment and Complications
- Retinal and Optic Conditions
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Bone Tumor Diagnosis and Treatments
- Peripheral Neuropathies and Disorders
- Cancer Cells and Metastasis
- Pharmacological Effects and Toxicity Studies
- Cancer Treatment and Pharmacology
- Advanced Neuroimaging Techniques and Applications
- Clinical Nutrition and Gastroenterology
- Polyomavirus and related diseases
- Hallucinations in medical conditions
- Cerebrovascular and genetic disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Migraine and Headache Studies
- Boron Compounds in Chemistry
- Myasthenia Gravis and Thymoma
- Genetics and Neurodevelopmental Disorders
Wroclaw Medical University
2014-2024
University of Wrocław
2014-2024
Szpital Kliniczny Nr 1 we Wrocławiu
2014
Niepubliczna Wyższa Szkoła Medyczna
2001-2003
Abstract Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize forms additionally at threonine-212, but the contribution of p-tau212 alone to AD is unknown. We developed a blood-based immunoassay that specific without cross-reactivity p-tau217. Here, we examined diagnostic utility p-tau212. In five cohorts ( n = 388 participants), showed...
An analysis of the medical documentation and investigation 130 cases epilepsy diagnosed in a group people over 50 years age (average: 65.4 years) revealed that most common type seizure studied was partial (66.2%), followed by seizures with secondary generalization (33.8%). Epilepsy caused cerebrovascular disease (50.8%) considerably more often patients 74 age, craniocerebral trauma addicted to alcohol (13.1%), especially those under 65 primary or metastatic neoplastic (10.7%), others. The...
Background.Parkinson's disease (PD) is a progressive neurodegenerative disorder with characteristic clinical picture.Apart from classical movement disorders, significant role also played by non-motor symptoms, in particular cognitive impairments, which have impact on the quality of life patients.Tau protein and amyloid beta are well-known non-specific biomarkers Alzheimer's (AD).Objectives.The study assessed practical value determining tau (Aβ42) blood serum patients PD their relationship...
Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer's disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize forms additionally at threonine-212, but the contribution of p-tau212 alone to AD is unknown. We developed a blood-based immunoassay that specific without cross-reactivity p-tau217. Thereafter, we examined diagnostic utility p-tau212. In five cohorts (n=388 participants), showed performances...
Cerebellar stroke is a rare condition with very nonspecific clinical features. The symptoms in the acute phase could imitate peripheral vestibular disorders or brainstem lesion. aim of this study was to assess usefulness Trial Org 10172 Acute Stroke Treatment (TOAST) classification cerebellar and impact features on prognosis. We retrospectively analyzed 107 patients diagnosed ischemic infarction. studied compared them based location lesion its distribution posterior interior artery (PICA),...
Background.Cerebrovascular disease is an important cause of epilepsy.The incidence may significantly vary (from 2.3% to 43%).Post-stroke seizures occur within 2 weeks stroke onset (as early-onset seizures) or after a late-onset seizures).Objectives.To retrospectively evaluate and differentiate predictive factors for post-stroke seizures.Material methods.We analyzed the medical histories 164 adult patients diagnosed with but no epilepsy recognized prior who were hospitalized at Neurology...
The purpose of this study was to classify ischaemic strokes according TOAST in patients treated the internal disease and neurological wards a hospital Lower Silesia, evaluate diagnostic therapeutic methods, compare their treatment effectiveness Rankin scale.Two hundred seventy-nine below 80 77 over years age suffering from stroke were covered by retrospective study.Patients with large-artery atherosclerosis classification old (p = 0.001) more frequently hospitalised ward 0.005). Strokes...
Gliomas are a heterogenous group of tumors that show the same histological features but differ in their behavior. characterized by biological aggressiveness and extensive infiltrative growth into surrounding healthy brain tissue.In this study we estimated CD44v6 E-cadherin expression correlation between relation to glioma malignancy. We also analyzed simultaneous tumor sample order determine behavior.Expression was evaluated on ninety-two formalin-fixed paraffin-embedded tissue blocks using...
Charles Bonnet syndrome is an underrecognized disease that involves visual hallucinations in visually impaired patients. We present the cases of three patients who experienced complex following various pathomechanisms. In two cases, diagnosis showed coexistence occipital lobe damage with ocular damage, while third case it retrobulbar optic neuritis. Theories pathogenesis and neuroanatomical basis are discussed supported by literature review.
Background. Cerebral venous thrombosis (CVT) is a rare condition which constitutes 0.5–1% of all strokes. The clinical and radiological picture CVT non-specific can mimic other disorders.Objectives. aim the study was to retrospectively evaluate correlate symptoms presented by patients with CVT, both in initial follow-up neurological neuroimaging examinations, special emphasis on diagnostic difficulties.Material Methods. Material consisted 11 (7 women, 4 men). average age 43.5, ranging from...
Objective: To estimate rates, predictors, and prognostic importance of recanalization in an unselected series patients with stroke treated IV thrombolysis.Methods: We performed a CT angiography or transcranial Doppler (TCD) follow-up examination 24 hours after thrombolysis 64 documented occlusion the intracranial internal carotid middle cerebral artery (MCA).Complete was defined by rating 3 on Thrombolysis Myocardial Infarction 4/5 Brain Ischemia grading scales.Information about risk...
The persistent trigeminal artery (PTA) is the most common foetal carotid-basilar anastomosis which may persist into adult life. In literature there are numerous papers referring to anatomical characteristics of this anomalous vessel. majority cases PTA an incidental finding and its clinical significance has been debated. Some authors describe coincidence with various syndromes. However, few reports linking symptoms vertebrobasilar insufficiency. We present a patient 3-year history recurrent...
Vasculitis is a heterogeneous group of disorders characterized by multifocal segmental inflammation the small and medium vessels central nervous system. The predominant symptoms cerebral vasculitis are stroke, headache, encephalopathy. Additional include seizures, cranial nerve palsies, myelopathy. Imaging techniques play crucial role in identifying diagnosis demonstrating brain involvement. An 89-year-old woman with permanent atrial fibrillation developed an embolic stroke. In treatment,...
A 47-year-old woman was admitted to our Neurology Department with a 13-year history of slowly progressing atrophy and weakness the upper extremities, numerous masses in supraclavicular regions.MRI examination (figure) revealed plexiform neurofibromas brachial plexuses, confirmed by biopsy.No other signs neurofibromatosis (NF) were seen.This case represents mosaic localized NF1, which arises from somatic mutations occurring late-stage differentiated cell, clinical manifestation restricted...
Abstract Extrapyramidal symptoms (EP) are not uncommon in Alzheimer’s Disease (AD); when present, they negatively influence the course of disorder. A large proportion AD patients shows concomitant Lewy bodies’ pathology post mortem. Total α Synuclein (αSyn) concentrations frequently increased cerebrospinal fluid (CSF) patients, but decreased Parkinson’s (PD) and Dementia with Bodies (DLB). αSyn CSF EP (EP+) have been reported so far. four Neurochemical Diagnostics (NDD) biomarkers, (Aβ1-42,...
Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder with characteristic clinical motor features combined non-motor symptoms. Cognitive impairment has very significant impact on the patient’s quality of life. The risk developing dementia six times higher in PD patients than general population and increases longer duration disease. Objectives: aim this study to assess cognitive its characteristics explore correlation between disease, stage, neuroimaging brain....