A5035185848- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Appendicitis Diagnosis and Management
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Eosinophilic Esophagitis
- Abdominal Surgery and Complications
- Gallbladder and Bile Duct Disorders
- Lipoproteins and Cardiovascular Health
- Cancer Genomics and Diagnostics
- Lipid metabolism and disorders
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- Intestinal Malrotation and Obstruction Disorders
- Bariatric Surgery and Outcomes
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
Los Angeles Medical Center
2016-2025
Kaiser Permanente
2016-2025
Cedars-Sinai Medical Center
2018-2024
University of Pittsburgh Medical Center
2024
Duke University
2024
Yale University
2024
Troy Gastroenterology
2014-2024
Kaiser Permanente West Los Angeles Medical Center
2013-2022
Johns Hopkins University
2015-2022
Stanford University
2022
The diagnosis of chronic pancreatitis remains challenging in early stages the disease. This report defines diagnostic criteria useful assessment patients with suspected and established pancreatitis. All current procedures are reviewed, evidence-based statements provided about their utility limitations. Diagnostic for classified as definitive, probable, or insufficient evidence. A (STEP-wise; survey, tomography, endoscopy, pancreas function testing) algorithm is proposed that proceeds from a...
OBJECTIVES: Our aim was to prospectively evaluate the ability of bedside index for severity in acute pancreatitis (BISAP) score predict mortality as well intermediate markers a tertiary center. METHODS: The BISAP evaluated among 397 consecutive cases admitted our institution between June 2005 and December 2007. scores were calculated on all using data within 24 h presentation. trend discrimination analysis. optimal cutoff from receiver operating curve used development organ failure,...
Background: Objective assessment of acute pancreatitis (AP) is critical to help guide resuscitation efforts.Herein we (1) validate serial blood urea nitrogen (BUN) measurement for early prediction mortality and (2) develop an objective BUN-based approach in AP.Methods: We performed a secondary analysis 3 prospective AP cohort studies: Brigham
Predicting severe acute pancreatitis (AP) remains a challenge. The present study compares admission blood urea nitrogen (BUN), hematocrit, and creatinine, as well changes in their levels over 24 h, aiming to determine the most accurate laboratory test for predicting persistent organ failure pancreatic necrosis.Clinical data of 1,612 AP patients, enrolled prospectively three independent cohorts (University Pittsburgh, Brigham Women's Hospital, Dutch Pancreatitis Study Group), were abstracted....
Several risk scoring systems exist for upper gastrointestinal bleed (UGIB). We hypothesised that a modified Glasgow Blatchford Score (mGBS) eliminates the subjective components of GBS might perform as well current systems.To compare performance mGBS to most widely reported prediction clinical outcomes in patients presenting with UGIB.Prospective cohort study from 9/2010 9/2011. Accuracy was compared full GBS, Rockall (RS) and RS using area under receiver operating characterstics-curve (AUC)....
BACKGROUND: Early stage diagnosis of Pancreatic Ductal Adenocarcinoma (PDAC) is challenging due to the lack specific diagnostic biomarkers. However, stratifying individuals at high risk PDAC, followed by monitoring their health conditions on regular basis, has potential allow early stages. OBJECTIVE: To stratify for PDAC identifying predictive features in pre-diagnostic abdominal Computed Tomography (CT) scans. METHODS: A set CT features, potentially was identified analysis 4000 raw radiomic...
OBJECTIVES: Chronic pancreatitis (CP) is associated with risk factors that may negatively impact bone and mineral metabolism. The important clinical end point of osteoporosis “low-trauma” fracture. purpose this study was to examine the prevalence fracture in patients CP, compared rates “high-risk” gastrointestinal (GI) illnesses, for which metabolic disease screening guidelines are place. METHODS: This a retrospective cohort database examining CP GI illnesses seen at single tertiary care...
An international symposium entitled "Acute pancreatitis: progress and challenges" was held on November 5, 2014 at the Hapuna Beach Hotel, Big Island, Hawaii, as part of 45th Anniversary Meeting American Pancreatic Association Japanese Pancreas Society. The course organized directed by Drs. Stephen Pandol, Tooru Shimosegawa, Robert Sutton, Bechien Wu, Santhi Swaroop Vege. objectives were to: (1) highlight current issues in management acute pancreatitis, (2) discuss promising treatments, (3)...
Pancreatic cystic neoplasms (PCNs) are being detected with increased frequency. The aims of this study were to determine the incidence malignancy and develop an imaging-based system for prediction in PCN.We conducted a retrospective cohort patients ≥18 years age confirmed PCN from January 2005 December 2010 community-based integrated care setting Southern California. Patients history acute or chronic pancreatitis excluded. Malignancy diagnosed within 3 months cyst diagnosis was considered as...
OBJECTIVES: The Pancreatitis Activity Scoring System (PASS) has been derived by an international group of experts via a modified Delphi process. Our aim was to perform external validation study assess for concordance the PASS score with high face validity clinical outcomes and determine specific meaningful thresholds assist in application this scoring system large prospectively ascertained cohort. METHODS: We analyzed data from prospective cohort consecutive patients admitted Los Angeles...
Background: Although advanced pancreatic ductal adenocarcinoma (PDAC) is characterized by progressive weight loss and nutritional deterioration, the effect of cancer cachexia body mass index (BMI) at diagnosis on survival remains unclear. Methods: We retrospectively evaluated a prospectively collected internal registry PDAC cases from 2006–2014 Kaiser Permanente Medical Center. Cancer was defined as greater than 5% over 6 months prior to diagnosis. Multivariate cox proportional hazards...
The risks and benefits of surveillance colonoscopy in elderly patients have not been well characterized.To investigate the relative impact compared with a reference cohort.Retrospective cohort study from 2001 through 2010 50 years older undergoing for history colorectal cancer (CRC) or adenomatous polyps at an integrated health care system southern California. Patients were followed up examination until CRC diagnosis, death, disenrollment, IBD end date (December 31, 2010).The primary outcome...
Acute pancreatitis has a highly variable course. Currently there is no widely accepted method to measure disease activity in patients hospitalized for acute pancreatitis. We aimed develop clinical index that incorporates routine parameters assist the measurement, study, and management of pancreatitis.We used UCLA/RAND appropriateness identify items inclusion instrument. conducted systematic literature review followed by two sets iterative modified Delphi meetings including panel...
Background Pancreatic cancer has poor prognosis and existing interventions provide a modest benefit. Statin anti-cancer properties that might enhance survival in pancreatic patients. We sought to determine whether statin treatment after diagnosis is associated with longer those ductal adenocarcinoma (PDAC). Methods analyzed data on 7813 elderly patients PDAC using the linked Surveillance, Epidemiology, End Results (SEER) - Medicare claims files. Information type, intensity duration of use...
Recent studies have suggested associations between statins and enhanced survival among patients with pancreatic ductal adenocarcinoma (PDAC). However, the relationship statins, cholesterol, remains unclear.We conducted a retrospective cohort study on 2142 PDAC in regional integrated healthcare system from 2006 to 2014. Electronic pharmacy records were used abstract information type, length, dosage of statin exposures starting year prior diagnosis. The cumulative individual effects...