A5015964897- Birth, Development, and Health
- Pneumonia and Respiratory Infections
- Morphological variations and asymmetry
- 3D Shape Modeling and Analysis
- Genetic Associations and Epidemiology
- Shoulder Injury and Treatment
- Meningioma and schwannoma management
- Pancreatitis Pathology and Treatment
- Shoulder and Clavicle Injuries
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Body Composition Measurement Techniques
- Helicobacter pylori-related gastroenterology studies
- Glioma Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Neonatal and Maternal Infections
- Health, Environment, Cognitive Aging
- Human-Animal Interaction Studies
- Receptor Mechanisms and Signaling
- Empathy and Medical Education
- Bacterial Infections and Vaccines
- Sexual Differentiation and Disorders
- MicroRNA in disease regulation
- Brain Metastases and Treatment
Leipzig University
2017-2024
Sheffield Hallam University
2020
IFB Adiposity Diseases
2019
Abstract Spermatozoa harbour a complex and environment-sensitive pool of small non-coding RNAs (sncRNAs) 1 , which influences offspring development adult phenotypes 1–7 . Whether spermatozoa in the epididymis are directly susceptible to environmental cues is not fully understood 8 Here we used two distinct paradigms preconception acute high-fat diet dissect epididymal versus testicular contributions sperm sncRNA health. We show that spermatozoa, but developing germ cells, sensitive...
Journal Article Cohort Profile: The LIFE-Adult-Study Get access Christoph Engel, Engel Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, GermanyLeipzig Research Centre Civilization Diseases, Germany Corresponding author. Haertelstrasse 16–18, 04107 Germany. E-mail: christoph.engel@imise.uni-leipzig.de https://orcid.org/0000-0002-7247-282X Search other works by this author on: Oxford Academic PubMed Google Scholar Kerstin Wirkner, Wirkner Samira...
The human retina is a multilayered tissue that offers unique window into systemic health. Optical coherence tomography (OCT) widely used in eye care and allows the noninvasive, rapid capture of retinal anatomy exquisite detail. We conducted genotypic phenotypic analyses layer thicknesses using macular OCT images from 44,823 UK Biobank participants. performed cross-phenotype association (OCT-XWAS), associating with 1866 incident conditions (median 10-year follow-up) 88 quantitative traits...
Here we report a heterozygous tandem duplication at the ASIP (agouti signaling protein) gene locus causing ubiquitous, ectopic expression in female patient with extreme childhood obesity. The mutation places under control of ubiquitously active itchy E3 ubiquitin protein ligase promoter, driving generation patient-derived native and induced pluripotent stem cells for all germ layers hypothalamic-like neurons. patient's phenotype early-onset obesity, overgrowth, red hair hyperinsulinemia is...
Steroid hormones are important regulators of physiological processes in humans and under genetic control. A link to coronary artery disease (CAD) is supposed.Our main objective was identify loci influencing steroid hormone levels. As a secondary aim, we searched for causal effects on CAD.We conducted genome-wide meta-association studies eight hormones: cortisol, dehydroepiandrosterone sulfate (DHEAS), estradiol, testosterone two independent cohorts (LIFE-Adult, LIFE-Heart, maximum n = 7667),...
Abstract X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related ( n = 908,697), identifying 23 loci genome-wide significantly associated with two the traits: 7 for uric acid 16 estimated glomerular filtration rate (eGFR), including four novel eGFR containing functionally plausible prioritized genes ACSL4 ,...
Abstract Background It is not known how much information clients retrieve from discharge instructions. Objective To investigate client's understanding of instructions and influencing factors. Animals Dogs cats being hospitalized for neurological diseases. Methods Clients were presented questionnaires regarding their pet's disease, diagnostics, treatments, prognosis at time 2 weeks later. The same questions answered by discharging veterinarians discharge. additional the subjective feelings...
Obesity can affect linear growth of children but there is uncertainty regarding the dynamics and potential causes.In population-based LIFE Child obesity-enriched Leipzig Childhood cohorts (8,629 children, 37,493 measurements), recruited from 1999 to 2018 in Germany, we compared height, growth, endocrine parameters between normal-weight with obesity (0-20 years). Derived independent German CrescNet registry (12,703 children) generated height reference values specific for (data collected...
Obesity develops early in childhood and is accompanied by signs of adipose tissue (AT) dysfunction metabolic disease children. In order to analyse the molecular processes during obesity-related AT accumulation children, we investigated genome-wide expression profiles samples, isolated adipocytes, stromal vascular fraction (SVF) cells assessed their relation obesity as well biological functional parameters. We detected alterations gene associated with related parameters, i.e., BMI SDS,...
Traditional body measurement techniques are commonly used to assess physical health; however, these approaches do not fully represent the complex shape of human body. Three-dimensional (3D) imaging systems capture rich point cloud data that provides a representation surface 3D objects and have been shown be potential anthropometric tool for use within health applications. Previous studies utilising only assessed based on combinations relative proportions traditional measures, such as...
Background: Community-acquired pneumonia (CAP) is an acute disease condition with a high risk of rapid deteriorations. We analysed the influence genetics on cytokine regulation to obtain better understanding patient’s heterogeneity. Methods: For up N = 389 genotyped participants PROGRESS study hospitalised CAP patients, we performed genome-wide association ten cytokines IL-1β, IL-6, IL-8, IL-10, IL-12, MCP-1 (MCAF), MIP-1α (CCL3), VEGF, VCAM-1, and ICAM-1. Consecutive secondary analyses were...
Abstract Background The presence of muscular deficiency seems to be a major cause back pain that requires counteractions. Considering the autochthonous muscles, responsible for straightening and stabilizing spine, cannot activated voluntarily, they can strengthened only through specific training. computer-supported test training system (CTT) Centaur (BfMC GmbH, Leipzig, SN, Germany) well suited this purpose. To show its potential as reliable diagnostic tool, study aimed evaluate test-retest...
Body height, body mass index, hip and waist circumference are important risk factors or outcome variables in clinical epidemiological research with complex underlying genetics. However, these classical anthropometric traits represent only a very limited view on the human other potentially higher functional specificity not yet studied to larger extent. Participants of LIFE-Adult were assessed by three-dimensional scanner VITUS XXL determining 99 high-quality parallel. Genotyping was performed...
Traditional manual anthropometrics have been used extensively in practice to derive indicators of health risk, such as growth disorders or obesity; however, these approaches typically reduce the complex shape human bodies a series simple size measures.Three-dimensional (3D) imaging systems capture detailed and accurate images morphology which potential for use within applications.However, previous studies utilising 3D only assessed body based on combinations relative proportions large...
Mit einer datengestützten Cluster-Einteilung bei Menschen mit Adipositas und Typ-2-Diabetes (T2D) konnte nachgewiesen werden, dass insbesondere Personen Insulinresistenz von adipositaschirurgischen Therapie profitieren. Bislang ist unklar, ob eine datengestützte auch konservativer Gewichtsreduktion einem differentiellen therapeutischen Outcome assoziiert ist.
There are limited data on the influence of different anti-cancer therapies lymphocyte subpopulations and their relationships to survival non-small cell lung cancer (NSCLC) patients. This study aimed assess effect immunotherapy, chemotherapy, immunochemotherapy, adjuvant chemotherapy after surgery, antibodies against Vascular Endothelial Growth Factors (VEGF) B cell, T NK subpopulations, time NSCLC patients.A total 32 consecutive patients were recruited at Pulmonology Clinic, Leipzig from...
Die Körperoberfläche ist als physiologische Größe für viele medizinische Anwendungen relevant. In der Praxis wird die über empirische Formeln – häufig basierend auf und Gewicht ermittelt. Lasergestützte 3D-Anthropometrie ermöglicht es, einfach effektiv zu messen. einer bevölkerungsbasierten Studie wurde diese Methode verwendet, um Validität veröffentlichter verwendeter empirischer überprüfen.