Nicola Pirastu
A5044208104- Genetic Associations and Epidemiology
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Genetic Mapping and Diversity in Plants and Animals
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
- Genetic and phenotypic traits in livestock
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Sensory Analysis and Statistical Methods
- Advanced Chemical Sensor Technologies
- Liver Disease Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Oral microbiology and periodontitis research
- Hearing, Cochlea, Tinnitus, Genetics
- melanin and skin pigmentation
- Culinary Culture and Tourism
- Bioinformatics and Genomic Networks
- Kruppel-like factors research
- Obesity, Physical Activity, Diet
- Genetics and Neurodevelopmental Disorders
- Coffee research and impacts
- Gout, Hyperuricemia, Uric Acid
- Hemoglobinopathies and Related Disorders
Human Technopole
2022-2025
University of Edinburgh
2017-2024
Centre for Global Health Research
2017-2024
University of Colorado Anschutz Medical Campus
2022
University of Trieste
2011-2022
University of Arizona
2022
Edinburgh College
2020
University of Naples Federico II
2017
IRCCS Materno Infantile Burlo Garofolo
2010-2016
University of Cambridge
2016
Many existing cohorts contain a range of relatedness between genotyped individuals, either by design or chance. Haplotype estimation in such is central step many downstream analyses. Using genotypes from six isolated populations and two non-isolated populations, we have investigated the performance different phasing methods designed for nominally ‘unrelated’ individuals. We find that SHAPEIT2 produces much lower switch error rates all compared to other methods, including those specifically...
Abstract Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 chemosensory impairments, such as anosmia. However, these downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, generally lacked quantitative measurements. Here, we report the development, implementation, initial results multilingual, international questionnaire assess self-reported quantity quality perception in 3 distinct modalities (smell, chemesthesis) before...
Although several studies demonstrated that platelet count is higher in women, decreases with age, and influenced by genetic background, most clinical laboratories still use the reference interval 150-400×10(9) platelets/L for all subjects. The present study was to identify age- sex-specific intervals count.We analysed electronic records of subjects enrolled three population-based investigated inhabitants seven Italian areas including six geographic isolates. After exclusion patients...
While volunteer-based studies such as the UK Biobank have become cornerstone of genetic epidemiology, participating individuals are rarely representative their target population. To evaluate impact selective participation, here we derived participation probabilities on basis 14 variables harmonized across and a sample. We then conducted weighted genome-wide association analyses 19 traits. Comparing output from (n
We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole genome sequence data from 20 studies predominantly European ancestry. Using this resource leads to accurate genotype imputation minor allele frequencies as low 0.1%, large increase in the number tested association and can help discover refine causal loci. remote server resources that allow researchers carry out phasing consistently efficiently.
Abstract We present the results of a GWAS food liking conducted on 161,625 participants from UK-Biobank. Liking was assessed over 139 specific foods using 9-point scale. Genetic correlations coupled with structural equation modelling identified multi-level hierarchical map food-liking three main dimensions: “Highly-palatable”, “Acquired” and “Low-caloric”. The Highly-palatable dimension is genetically uncorrelated other two, suggesting that independent processes underlie high reward foods....
Diet is considered as one of the most important modifiable factors influencing human health, but efforts to identify foods or dietary patterns associated with health outcomes often suffer from biases, confounding, and reverse causation. Applying Mendelian randomization in this context may provide evidence strengthen causality nutrition research. To end, we first identified 283 genetic markers intake 445,779 UK Biobank participants. We then converted these associations into direct effects on...
Food liking-disliking patterns may strongly influence food choices and health. Here we assess: (1) whether preference are genetic/environmentally driven; (2) the relationship between metabolomics profiles in a large population of twins. 2,107 individuals from TwinsUK completed an online lifestyle questionnaire. Principle components analysis was undertaken to identify liking-disliking. Heritability estimates for each liking pattern were obtained by structural equation modeling. The...