A5063146676- Bladder and Urothelial Cancer Treatments
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Diabetes Management and Research
- Renal and related cancers
- Pregnancy and preeclampsia studies
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Birth, Development, and Health
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Diabetes and associated disorders
- Dialysis and Renal Disease Management
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Gestational Diabetes Research and Management
- Chronic Kidney Disease and Diabetes
- Fibroblast Growth Factor Research
- Regulation of Appetite and Obesity
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Nutrition and Health in Aging
- Immunotherapy and Immune Responses
Leipzig University
2014-2025
University Hospital Leipzig
2016-2025
Karolinska Institutet
2019-2024
Klinik und Poliklinik für Neurologie
2014-2024
IFB Adiposity Diseases
2012-2022
Helmholtz-Institute Ulm
2022
Universität Ulm
2022
Zero to Three
2021
Baxter (Sweden)
2020
GKV Spitzenverband
2020
Once roentgenographic changes are apparent, osteonecrosis of the femoral head in adult generally progresses to osteoarthritis within two three years. A variety conservative surgical procedures have been devised conserve with varying success. This study examines effectiveness pulsing electromagnetic fields and core decompression treatment head. Both techniques reduce incidence clinical progression. Exposure appears be more effective hips Ficat II lesions than advanced lesions.
Objective Irisin has recently been introduced as a novel myokine which reverses visceral obesity and improves glucose metabolism in mice. However, regulation of irisin humans relation to renal metabolic disease not comprehensively studied. Design methods Serum levels were quantified by ELISA correlated with anthropometric biochemical parameters function, lipid metabolism, well inflammation, 532 patients stages 1–5 chronic kidney (CKD). Results Median serum adjusted for age, gender, BMI...
Abstract Kidney failure and associated uraemia have implications for the cardiovascular system, brain, blood–brain barrier (BBB). We aim to examine BBB disruption, by assessing brain-derived neurotropic factor (BDNF), neuron-specific enolase (NSE) levels, gut-blood (GBB) disruption trimethylamine N-oxide (TMAO), in chronic kidney disease (CKD) patients. Additionally, endothelial tight-junction protein expressions modulation via TMAO were assessed. Serum from female male haemodialysis (HD)...
The NQO1 locus on chromosome 16q2.2 encodes NAD(P)H:quinone oxidoreductase, an enzyme implicated in detoxication and protection against redox cycling. Two alleles have been identified the human population, rarer one, termed null-allele, coding for a nonfunctional enzyme. Since lack of NQOR activity has suggested to increase susceptibility certain cancers, distribution two was determined by polymerase chain reaction-restriction fragment length polymorphism analysis patients with renal cell...
Fibroblast growth factor (FGF)-21 has recently been introduced as a circulating adipokine which reverses insulin resistance and obesity in rodents. In this study, regulation of FGF-21 renal dysfunction was elucidated both chronic kidney disease (CKD) acute (AKD).Serum concentrations total were quantified by enzyme-linked immunosorbent assay 499 patients with CKD stages 1-5 (study population 1). Furthermore, determined before within 30 h after unilateral nephrectomy, model AKD, 32 2). levels...
Abstract Objective Adipose tissue–derived signals potentially link obesity and adipose tissue dysfunction with metabolic cardiovascular diseases. Although some adipocytokines have been closely related to traits, it is unknown which adipocytokine or clusters serve as meaningful markers of syndrome (MS) components. Therefore, this study investigated the associations 12 components MS identify most relevant cytokines specific profiles. Research Design Methods Twelve [adiponectin, adipocyte fatty...
Hormonal treatment in transgender persons affects many components of the metabolic syndrome (MS).To determine role direct hormonal effects, changes cytokines, and body composition on outcomes.24 transwomen 45 transmen from European Network for Investigation Gender Incongruence were investigated at baseline after 12 months therapy.Best predictors MS, applying least absolute shrinkage selection operator regression.In transwomen, a decrease triglyceride levels was best explained by fat mass an...
How does once-weekly subcutaneous tirzepatide affect maintenance of weight loss in individuals with obesity or overweight?
Summary Objective Pre‐eclampsia (PE) is a serious cardiovascular complication in pregnancy which shares risk factors with the metabolic syndrome including insulin resistance and obesity. Recently, visfatin was introduced as novel insulin‐mimetic adipokine up‐regulated when weight gained. In current study, we investigated serum levels pre‐eclamptic patients compared to healthy gestational age‐matched controls. Patients measurements Visfatin quantified by ELISA control ( n = 20) PE 15)...
Rather than a traditional growth factor, fibroblast factor-21 (FGF21) is considered to be metabolic hormone. In the current study, we investigated serum FGF21 levels in self-contained population of Sorbs. Serum concentrations were quantified by ELISA and correlated with IGF1 as well metabolic, renal, hepatic, inflammatory, cardiovascular parameters 913 Sorbs from Germany. Moreover, human protein secretion was FGF21-stimulated HepG2 cells. Median 2.1-fold higher subjects type 2 diabetes...
Betatrophin has recently been introduced as a novel adipokine/hepatokine, which promotes pancreatic β cell proliferation and improves glucose tolerance in several mouse models of insulin resistance. However, regulation betatrophin gestational diabetes mellitus (GDM), well its association with markers obesity, such lipid metabolism, inflammation, renal function, have not elucidated.Circulating was quantified 74 women GDM healthy age-matched controls by ELISA. In subset the study population...
<b><i>Background/Aims:</i></b> Altered expression and circulating levels of glutathione peroxidase 3 (GPX3) have been observed in obesity type 2 diabetes (T2D) across species. Here, we investigate whether GPX3 serum concentrations adipose tissue (AT) <i>GPX3</i> mRNA are related to weight loss. <b><i>Methods:</i></b> concentration was measured 630 individuals, including a subgroup (<i>n</i> = 293) for which omental...
Angiopoietin-like protein 8 (Angptl8) has recently been introduced as a novel adipokine/hepatokine that promotes pancreatic β-cell proliferation and improves glucose tolerance in mouse models of insulin resistance. However, regulation Angptl8 human type 2 diabetes mellitus (T2DM) renal dysfunction not determined. Serum levels were quantified by ELISA 62 patients with T2DM compared 58 nondiabetic subjects vivo. Within both groups, about half the on chronic hemodialysis or had an estimated...
Rising atmospheric CO2 concentrations will significantly reduce ocean pH during the 21st century (ocean acidification, OA). This may hamper calcification in marine organisms such as corals and echinoderms, shown many laboratory-based experiments. Sea urchins are considered highly vulnerable to OA. We studied an Echinometra species on natural volcanic vents Papua New Guinea, where they -acclimatized also subjected secondary ecological changes from elevated . Near vent site, experienced large...
OBJECTIVE To explore whether insulin resistance, assessed by estimated glucose disposal rate (eGDR), is associated with cardiorenal risk and it modifies finerenone efficacy. RESEARCH DESIGN AND METHODS In FIDELITY (N = 13,026), patients type 2 diabetes, either 1) urine albumin-to-creatinine ratio (UACR) of ≥30 to &lt;300 mg/g glomerular filtration (eGFR) ≥25 ≤90 mL/min/1.73 m2 or 2) UACR ≥300 ≤5,000 eGFR m2, who also received optimized renin-angiotensin system blockade, were randomized...
Abstract Aims/hypothesis As the prevalence of insulin resistance and glucose intolerance is increasing throughout world, diabetes-induced eye diseases are a global health burden. We aim to identify distinct optical bands which closely related metabolism, using non-invasive, high-resolution spectral domain coherence tomography (SD-OCT) in large, population-based dataset. Methods The LIFE-Adult-Study randomly selected 10,000 participants from population registry Leipzig, Germany....