A5047837989- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Visual perception and processing mechanisms
- Retinal and Optic Conditions
- Health, Environment, Cognitive Aging
- Optical Coherence Tomography Applications
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Digital Imaging for Blood Diseases
- Blood Pressure and Hypertension Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pregnancy and preeclampsia studies
- Advanced Fluorescence Microscopy Techniques
- Psychosomatic Disorders and Their Treatments
- Image Processing Techniques and Applications
- Older Adults Driving Studies
- Genetic Associations and Epidemiology
- Cardiovascular Health and Disease Prevention
- Ocular Infections and Treatments
- Cardiovascular Issues in Pregnancy
- Cerebral Venous Sinus Thrombosis
- Spatial Neglect and Hemispheric Dysfunction
Leipzig University
2016-2025
City, University of London
2008-2024
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2019-2024
University Hospital Leipzig
2011-2022
Hochschule Aalen
2008
The LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, major city with 550,000 inhabitants in east Germany. It first study this kind and size an urban population eastern part conducted by Leipzig Research Centre for Civilization Diseases (LIFE). Our objective to investigate prevalences, early onset markers, genetic predispositions, role lifestyle factors civilization diseases,...
Background Glaucoma is a progressive eye disease and leading cause of visual disability. Automated assessment the field determines different stages in process: it would be desirable to link these measurements taken clinic with patient's actual function, or establish if patients compensate for their restricted view when performing everyday tasks. Hence, this study investigated movements glaucomatous viewing driving scenes hazard perception test (HPT). Methodology/Principal Findings The HPT...
Journal Article Cohort Profile: The LIFE-Adult-Study Get access Christoph Engel, Engel Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, GermanyLeipzig Research Centre Civilization Diseases, Germany Corresponding author. Haertelstrasse 16–18, 04107 Germany. E-mail: christoph.engel@imise.uni-leipzig.de https://orcid.org/0000-0002-7247-282X Search other works by this author on: Oxford Academic PubMed Google Scholar Kerstin Wirkner, Wirkner Samira...
The human retina is a multilayered tissue that offers unique window into systemic health. Optical coherence tomography (OCT) widely used in eye care and allows the noninvasive, rapid capture of retinal anatomy exquisite detail. We conducted genotypic phenotypic analyses layer thicknesses using macular OCT images from 44,823 UK Biobank participants. performed cross-phenotype association (OCT-XWAS), associating with 1866 incident conditions (median 10-year follow-up) 88 quantitative traits...
Abstract Background To investigate environmental and social risk factors for myopia in children adolescents Germany. Methods 1437 aged between 3 18 inclusive were examined as part of the LIFE Child study based Leipzig, Information about leisure time activities status was ascertained by parents a questionnaire. Refractive attained measuring noncycloplegic autorefraction. Myopia defined spherical equivalent (SE) ≤ − 0.75 D. Risk identified using multiple logistic regression analysis. Results...
Abstract Aims/hypothesis As the prevalence of insulin resistance and glucose intolerance is increasing throughout world, diabetes-induced eye diseases are a global health burden. We aim to identify distinct optical bands which closely related metabolism, using non-invasive, high-resolution spectral domain coherence tomography (SD-OCT) in large, population-based dataset. Methods The LIFE-Adult-Study randomly selected 10,000 participants from population registry Leipzig, Germany....
Abstract Background and Objectives Associations between the occurrence of early age‐related macular degeneration (AMD) alterations in retinal layer thicknesses have been reported based on classical processing optical coherence tomography (OCT) data by noise removal subsequent image segmentation. However, speckle within OCT itself bears a substantial part total information. For this reason, an omics‐type approach was designed for full exploitation data, which able to identify signs AMD...
Abstract Purpose To evaluate ocular biometry in a large paediatric population as function of age and sex children European descent. Methods Children were examined part the LIFE Child Study (Leipzig Research Centre for Civilization Disease), population‐based study Leipzig, Germany. Altogether, 1907 children, aged from 4 to 17 years, with Lenstar LS 900. Data right eye was analysed axial length, central corneal thickness, flat steep radii, aqueous depth, lens thickness vitreous depth....
Associations between the occurrence of early age related macular degeneration (AMD) and alterations in retinal layer thicknesses have been reported, based on classical processing optical coherence tomography (OCT) data by noise removal subsequent image segmentation. However, speckle within OCT itself bears a substantial part total information. For this reason, we designed an omics-type approach for full exploitation data, which was able to identify signs AMD throughout retina as whole.
Abstract Background and Objectives Long before any signs of age‐related macular degeneration (AMD) become clinically noticeable, the disease starts with accumulation deposits extracellular debris formation lesions within outermost layers retina. For a reliable imaging in these early stages, optical coherence tomography (OCT) turned out to be largely preferable colour fundus photography. However, an adequate grading instrument for Early‐AMD OCT data is missing literature as yet. The present...
In ophthalmology, the angle between center of optic nerve head and sharpest vision (foveola) is a posterior fundus landmark parameter retina human eye. Together with disc-fovea distance, it characterizes position in relationship to foveola. The markedly influences regional distribution retinal layer thickness patterns, specifically fiber measured at disc. Thus, needs be determined routinely taken into account morphological glaucoma diagnosis assessment structure-function diseases. However,...
Optical coherence tomography (OCT) manufacturers graphically present circumpapillary retinal nerve fiber layer thickness (cpRNFLT) together with normative limits to support clinicians in diagnosing ophthalmic diseases. The impact of age on cpRNFLT is typically implemented by linear models. strongly location-specific, whereas previously published norms are restricted coarse sectors and based small populations. Furthermore, OCT devices neglect impacts lens or eye size the diameter scan circle...
Abstract Background Circumpapillary retinal nerve fiber layer thickness (cpRNFLT) as assessed by spectral domain optical coherence tomography (SD-OCT) is a new technique used for the detection and evaluation of glaucoma other optic neuropathies. Before translating cpRNFLT into clinics, it crucially important to investigate anthropometric, biochemical, clinical parameters potentially affecting in large population-based dataset. Methods The LIFE-Adult Study randomly selected 10,000...
Abstract Purpose To evaluate the feasibility and repeatability of Lenstar LS 900 biometry measurements in a paediatric population. Methods Children were examined as part LIFE Child Study (Leipzig Research Centre for Civilization Diseases), population‐based study Leipzig, Germany. Altogether, 1917 children, aged from 3.5 to 17.5 years, assessed with Haag Streit 900. Three consecutive right eye analysed axial length, central corneal thickness, anterior chamber depth, aqueous lens thickness...
Optical coherence tomography (OCT) is an established diagnostic tool for retinal pathologies in human eyes and has been adapted to small animal models. However, there have only a few attempts use OCT examination of avian eyes, little known about structural details healthy or pathologically affected retinas living birds.We used SD-OCT (high-resolution spectral domain OCT) investigate various species including birds prey. The were anesthetized by isoflurane application during examination. Eyes...
Cross-sectional survey of ocular biometry and visual function in healthy eyes across the life span a German population aged 20 to 69 years (n = 218). Subject number percent per age category reflected percentage within respective band Leipzig, Germany. Measurements obtained: subjective objective refraction, best-corrected acuity, accommodation, contrast sensitivity, topography pachymetry with Scheimpflug camera, axial length non-contact partial coherence interferometry, spectral-domain...