A5011402411- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Cardiac pacing and defibrillation studies
- Health, Environment, Cognitive Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Lipid metabolism and disorders
- Body Composition Measurement Techniques
- Transplantation: Methods and Outcomes
- Nutrition, Genetics, and Disease
- Cardiac and Coronary Surgery Techniques
- Electrospun Nanofibers in Biomedical Applications
- Infectious Aortic and Vascular Conditions
- Orthopedic Infections and Treatments
- Aortic aneurysm repair treatments
- Advanced Thermodynamics and Statistical Mechanics
- Obstructive Sleep Apnea Research
- Atrial Fibrillation Management and Outcomes
- Stress Responses and Cortisol
- Apelin-related biomedical research
Leipzig Heart Institute
2013-2025
Leipzig University
2011-2024
Deutsches Herzzentrum der Charité
2023-2024
Cedars-Sinai Smidt Heart Institute
2019-2022
Cedars-Sinai Medical Center
2018-2022
IFB Adiposity Diseases
2012-2019
University Hospital Leipzig
2013
University Medical Center
2012
The LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, major city with 550,000 inhabitants in east Germany. It first study this kind and size an urban population eastern part conducted by Leipzig Research Centre for Civilization Diseases (LIFE). Our objective to investigate prevalences, early onset markers, genetic predispositions, role lifestyle factors civilization diseases,...
ABSTRACT Background Little is known about the clinical and hemodynamic outcome of valve‐in‐valve transcatheter aortic valve replacement (ViV‐TAVR) for failed Trifecta surgical bioprotheses. Aims We aimed to compare outcomes (ViV‐TAVR into TM vs. ViV‐TAVR a standard bioprosthetic with internally mounted leaflets (Epic , Abbott, Minneapolis, MN). Methods Data consecutive patients who underwent either or Epic bioprostheses between October 2015 June 2020 were retrospectively collected within...
Changes in estradiol during aging are associated with increased dementia risk. It remains unclear how supports cognitive health and whether risk factors, such as midlife obesity, exacerbated by estrogen loss.To assess visceral adipose tissue (VAT) moderates the association between age brain network structure to investigate VAT structure.Cross-sectional study of data from 974 cognitively healthy adults Germany who participated Health Study Leipzig Research Centre for Civilization Diseases, a...
Objectives To investigate whether the metabolically important visceral adipose tissue (VAT) relates differently to structural and functional brain changes in comparison with body weight measured as mass index (BMI). Moreover, we aimed these effects change age. Design Cross-sectional, exploratory. Setting University Clinic, Integrative Research Treatment Centre. Participants We included 100 (mean BMI=26.0 kg/m², 42 women) out of 202 volunteers randomly invited by city's registration office,...
Background As transcatheter aortic valve replacement (TAVR) is expected to progress into younger patient populations, valve-in-TAVR (ViTAVR) may become a frequent consideration. Data on ViTAVR, however, are limited. This study investigated the outcome of ViTAVR in comparison surgical (ViSAVR), because ViSAVR an established procedure for higher-risk patients requiring repeated intervention. Methods and Results Clinical procedural data who underwent at 3 sites United States Germany were...
An 84-year-old patient presented at our outpatient clinic with recurrent dyspnoea (NYHA class III) and fever. Medical history included transcatheter aortic valve replacement (TAVR) using a 31 mm Corevalve prosthesis 6 months ago. Trans-thoracic echocardiography revealed moderate regurgitation also perforation of the anterior mitral leaflet (AML) causing severe …
The prevalence of mitral valve (MV) disease is increasing, as the interest in modern minimally invasive MV surgery (1,2). In concordance, age patients being referred for also increasing. This growing population elderly deserves special consideration due to inherent increased surgical risk with presence mostly significant co-morbidities (3). The operative mortality octogenarians who undergo has been reported be high 25% poor long-term outcomes (3). Quality life after described suboptimal...
Abstract OBJECTIVES To compare isolated primary bioprosthetic surgical aortic valve replacement (SAVR) with redo (rSAVR) due to structural deterioration (SVD). METHODS Clinical data of consecutive patients who underwent SAVR and rSAVR SVD between January 1, 2011, December 31, 2022, at Leipzig Heart Center were retrospectively compared regard the outcome all-cause mortality or stroke during hospitalization. Secondary outcomes interest included myocardial infarction, re-exploration for...
Components of the growth hormone (GH) axis, such as insulin-like factor-1 (IGF-1), IGF-1 binding protein-3 (IGFBP-3), GH receptor (GHR) and GH-binding protein (GHBP), regulate metabolic pathways. Here, we asked if serum levels these factors are altered with overweight/obesity this is related to adipose tissue (AT) expression and/or increased fat mass. Furthermore, hypothesized that GHR, IGFBP-3 associated AT function. Serum GHBP were in children throughout childhood, while for IGF-1/IGFBP-3...
<b>Purpose:</b> The purpose of this study is to establish and validate a magnetic resonance (MR)-based fat quantification package that provides an accurate assessment abdominal adipose tissue liver in children. <b>Materials Methods:</b> Ex vivo trials with torso model water-oil mixtures are conducted. Abdominal (AAT) covered by imaging (MRI) using fat-selective sequence analyzed plug-in based on the open source software ImageJ. Liver (LF) measured localized <sup>1</sup>H Magnetic Resonance...
Transcatheter mitral edge-to-edge repair is a well-established treatment option for regurgitation (MR) in high-operative risk patients. Device embolization potential, however not yet described risk. We herein present two cases of late Mitraclip® embolization. Successful and uneventful implantation was performed 64 [Pat. A; …
Background The aim of this study was to quantify acute mitral valve (MV) geometry dynamic changes throughout the cardiac cycle using three-dimensional transesophageal echocardiography (3D TEE) in patients undergoing surgical MV repair (MVR) with ring annuloplasty and optional neochord implantation. Methods Twenty-nine (63 ± 10 years) severe primary regurgitation underwent MVR or without We recorded 3D TEE data before after MVR. Dynamic (4D) annulus anatomical orifice area (AMVOA) were...