A5082249591- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Angiogenesis and VEGF in Cancer
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cell Adhesion Molecules Research
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrhythmias and Treatments
- Antimicrobial Resistance in Staphylococcus
- Acute Myocardial Infarction Research
- Protease and Inhibitor Mechanisms
- Cardiac pacing and defibrillation studies
- Orthopedic Infections and Treatments
- Cardiovascular Health and Disease Prevention
- Anesthesia and Sedative Agents
- Cardiac tumors and thrombi
- Hematological disorders and diagnostics
- Inflammatory Biomarkers in Disease Prognosis
Leipzig University
2017-2024
University Hospital Leipzig
2017-2024
Leipzig Heart Institute
2015-2022
Klinikum St. Georg
2018-2022
Deutsches Herzzentrum der Charité
2021
German Centre for Cardiovascular Research
2013
Ludwig-Maximilians-Universität München
2009-2013
Transcatheter aortic valve implantation (TAVI) has emerged as established treatment option in patients with symptomatic stenosis. Technical developments design have addressed previous limitations such suboptimal deployment, conduction disturbances, and paravalvular leakage. However, there are only limited data available for the comparison of newer generation self-expandable (SEV) balloon-expandable (BEV). SOLVE-TAVI is a multicentre, open-label, 2 × factorial, randomized trial 447 stenosis...
Background: In clinical practice, local anesthesia with conscious sedation (CS) is performed in roughly 50% of patients undergoing transcatheter aortic valve replacement. However, no randomized data assessing the safety and efficacy CS versus general (GA) are available. Methods: The SOLVE-TAVI (Comparison Second-Generation Self-Expandable Versus Balloon-Expandable Valves General Local Anesthesia Transcatheter Aortic Valve Implantation) trial a multicenter, open-label, 2×2 factorial, 447...
Patients undergoing transcatheter aortic valve replacement (TAVR) are often characterized by risk factors not reflected in conventional scores. In this context, little is known about the outcome of patients suffering from an active cancer disease (ACD). The objective was to determine prevalence, clinical characteristics, perioperative outcomes, and mortality with ACD TAVR compared those a history (HCD) controls without tumor disease.TAVR between 02/2006 09/2014 were stratified according...
Impaired left ventricular (LV) ejection fraction is a common finding in patients with aortic stenosis and serves as predictor of morbidity mortality after transcatheter valve replacement. However, conflicting data on the most accurate measure for LV function exist. We wanted to examine impact fraction, mean pressure gradient, stroke volume index outcome treated by replacement.Patients replacement were primarily separated into normal flow (NF; >35 mL/m2) low (LF; ≤35 mL/m2). Afterwards,...
Background Infective endocarditis ( IE ) after transcatheter aortic valve replacement is a devastating complication associated with high mortality. Our objective was to determine the impact of cardiac surgery (CS) and antibiotics - CS compared medical treatment only AB x) on 1-year mortality in patients developing replacement. Methods Results Patients were included this retrospective analysis. All-cause primary end point. A total 20 underwent 44 treated by x. In unmatched cohort, x older...
Drug-coated balloons (DCBs) are an established treatment strategy for coronary artery disease. Randomized data on the application of DCBs in patients with acute syndrome (ACS) limited. We evaluated impact clinical presentation (ACS versus chronic syndrome) outcomes undergoing DCB or drug-eluting stent (DES) a prespecified analysis BASKET-SMALL 2 trial (Basel Kosten Effektivitäts Trial-Drug-Coated Balloons Versus Drug-Eluting Stents Small Vessel Interventions).BASKET-SMALL randomized 758...
Embryonal endothelial progenitor cells (eEPCs) are capable of inducing therapeutic angiogenesis in a chronic hind limb model. However, the proportion eEPCs recruited to ischemic tissue appears be limiting step for induction cell-based neovascularization. In present study, we primed with human cathelicidin LL37 (hCAP-18) ex vivo selectively enhance eEPC-dependent gain perfusion and elucidated mechanism action on eEPCs. Seven days after femoral artery excision, 5 x 10(6) (wt, wild type; p65t,...
Background As transcatheter aortic valve replacement (TAVR) is expected to progress into younger patient populations, valve-in-TAVR (ViTAVR) may become a frequent consideration. Data on ViTAVR, however, are limited. This study investigated the outcome of ViTAVR in comparison surgical (ViSAVR), because ViSAVR an established procedure for higher-risk patients requiring repeated intervention. Methods and Results Clinical procedural data who underwent at 3 sites United States Germany were...
Left ventricular outflow tract (LVOT) calcification has been associated with worse outcomes in patients undergoing transcatheter aortic valve implantation (TAVI) and may influence the selection of prosthetic type.
Red blood cell distribution width (RDW) is calculated in every count test and reflects variability erythrocyte size. High levels mirror dysregulated homeostasis have been associated with clonal hematopoiesis as well higher mortality several conditions.We aimed to determine the impact of preprocedural RDW on functional outcomes after transcatheter aortic valve implantation (TAVI).
The facilitated recruitment of vascular progenitor cells (VPCs) to ischemic areas might be a therapeutic target for neovascularization and repair. However, efficient directed attraction VPCs remains major challenge in clinical application. To enhance VPC homing, we developed fusion protein (S1FG), based on the biology stroma-derived factor-1/CXCL12 mucin backbone taken from fractalkine/CXCL12. A GPI-anchor was included link fusion-protein cell surface. HUVECs transfected with S1FG were...
Abstract Objectives To evaluate the impact of diabetes mellitus on 3 year clinical outcome in patients undergoing drug-coated balloon (DCB) or drug-eluting stent (DES) treatment for de-novo lesions. Background For coronary small vessel disease DCB are non-inferior to DES regarding up years. Methods In this prespecified analysis a multicenter, randomized, non-inferiority trial, including 758 with lesions vessels <3mm who were randomized 1:1 (n=382) (n=376) and followed over years major...
We evaluated the outcome of PCI de novo stenosis with drug-coated balloons (DCB) versus drug-eluting stents (DES) in patients insulin-treated diabetes mellitus (ITDM) non-insulin-treated (NITDM).Patients were randomized BASKET-SMALL 2 trial to DCB or DES and followed over 3 years for MACE (cardiac death, non-fatal myocardial infarction [MI], target vessel revascularization [TVR]). Outcome diabetic subgroup (n = 252) was analyzed respect ITDM NITDM.In NITDM 157), rates (16.7% vs. 21.9%,...
Abstract Objectives To evaluate the impact of previous coronary artery bypass grafting (CABG) on early safety at 30 days and 1‐year mortality in patients receiving transcatheter aortic valve replacement (TAVR). Background The use TAVR with CABG suffering from severe stenosis has increased last years. Methods Consecutive were stratified according to versus no cardiac surgery (control). All‐cause evaluated. Results In unmatched cohort compared control ( n = 2,364), 260) younger, more often...
Transcatheter aortic valve replacement (TAVR) has become the standard of care in majority patients with symptomatic severe stenosis. Data on long-term mortality and durability transcatheter heart valves (THVs) beyond 5 years are limited. Our study aimed to assess elderly high-risk patients' outcomes treated TAVR a prospective single-centre registry focusing THVs.We included 795 calcific stenosis by transfemoral between 2006 2011. Echocardiography was performed at baseline; discharge; 1 year;...