A5019284700- Biomedical Text Mining and Ontologies
- Electronic Health Records Systems
- Data Quality and Management
- Ethics in Clinical Research
- Semantic Web and Ontologies
- Cancer Genomics and Diagnostics
- Scientific Computing and Data Management
- Research Data Management Practices
- Genomics and Rare Diseases
- Artificial Intelligence in Healthcare
- Health, Environment, Cognitive Aging
- Sleep and Wakefulness Research
- Clinical practice guidelines implementation
- Privacy-Preserving Technologies in Data
- Sleep and Work-Related Fatigue
- Single-cell and spatial transcriptomics
- Statistical Methods in Clinical Trials
- Sleep and related disorders
- Nutritional Studies and Diet
- Health and Medical Studies
- Artificial Intelligence in Healthcare and Education
- Epigenetics and DNA Methylation
- Mobile Health and mHealth Applications
- Tryptophan and brain disorders
- Renal cell carcinoma treatment
Leipzig University
2010-2024
Heidelberg University
2022-2024
Deutschen Konsortium für Translationale Krebsforschung
2022-2024
University Medical Centre Mannheim
2022-2024
University Hospital Heidelberg
2022-2024
German Cancer Research Center
2021-2024
Life University
2024
Ruhr University Bochum
2022
The LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, major city with 550,000 inhabitants in east Germany. It first study this kind and size an urban population eastern part conducted by Leipzig Research Centre for Civilization Diseases (LIFE). Our objective to investigate prevalences, early onset markers, genetic predispositions, role lifestyle factors civilization diseases,...
Journal Article Cohort Profile: The LIFE-Adult-Study Get access Christoph Engel, Engel Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, GermanyLeipzig Research Centre Civilization Diseases, Germany Corresponding author. Haertelstrasse 16–18, 04107 Germany. E-mail: christoph.engel@imise.uni-leipzig.de https://orcid.org/0000-0002-7247-282X Search other works by this author on: Oxford Academic PubMed Google Scholar Kerstin Wirkner, Wirkner Samira...
An essential step in any medical research project after identifying the question is to determine if there are sufficient patients available for a study and where find them. Pursuing digital feasibility queries on patient data registries has proven be an excellent way of reusing existing real-world sources. To support multicentric research, these should designed implemented run across multiple sites securely access local data. Working hospitals usually involves working with different formats...
The COVID-19 pandemic highlighted the importance of making research data from all German hospitals available to scientists respond current and future pandemics promptly. heterogeneous originating proprietary systems at hospitals' sites must be harmonized accessible. Corona Consensus Dataset (GECCO) specifies how for patients will standardized in Fast Healthcare Interoperability Resources (FHIR) profiles across hospitals. However, given complexity FHIR standard, harmonization is not...
This study outlines the development of a highly interoperable federated IT infrastructure for academic biobanks located at major university hospital sites across Germany. High-quality biosamples linked to clinical data, stored in are essential biomedical research. We aimed facilitate findability these and their associated data. Networks provide access even larger pools samples data from rare diseases small disease subgroups. The German Biobank Alliance (GBA) established 2017 under umbrella...
Clinical trials are carried out to prove the safety and effectiveness of new interventions therapies. As diseases their causes continue become more specific, so do inclusion exclusion criteria for trials. Patient recruitment has always been a challenge, but with medical progress, it becomes increasingly difficult achieve necessary number cases. In Germany, Medical Informatics Initiative is planning use central application registration office conduct feasibility analyses at an early stage...
<sec> <title>BACKGROUND</title> An essential step in any medical research project after identifying the question is to determine if there are sufficient patients available for a study and where find them. Pursuing digital feasibility queries on patient data registries has proven be an excellent way of reusing existing real-world sources. To support multicentric research, these should designed implemented run across multiple sites securely access local data. Working hospitals usually involves...
Abstract Testing for genetic alterations in tumor tissue allows clinicians to identify patients who most likely will benefit from molecular targeted treatment. EXLIQUID – exploiting liquid biopsies advance cancer precision medicine investigates the potential of additional non-invasive tools guiding therapy decisions and monitoring advanced patients. The term “liquid biopsy” (LB) refers analysis tumor-derived circulating material such as cell-free DNA blood samples Although recent...
<sec> <title>BACKGROUND</title> To advance research with clinical data, it is essential to provide researchers fast and easy access the available which especially challenging for data from different source systems within across institutions. Over years, many repositories standards have been created. One of these FHIR standard, used by German Medical Informatics Initiative (MII) harmonize standardize university hospitals in Germany. first steps make this allow create feasibility queries...
To advance research with clinical data, it is essential to make access the available data as fast and easy possible for researchers, which especially challenging from different source systems within across institutions. Over years, many repositories standards have been created. One of these Fast Healthcare Interoperability Resources (FHIR) standard, used by German Medical Informatics Initiative (MII) harmonize standardize university hospitals in Germany. first steps allow researchers create...
<sec> <title>BACKGROUND</title> The COVID-19 pandemic highlighted the importance of making research data from all German hospitals available to scientists respond current and future pandemics promptly. heterogeneous originating proprietary systems at hospitals' sites must be harmonized accessible. Corona Consensus Dataset (GECCO) specifies how for patients will standardized in Fast Healthcare Interoperability Resources (FHIR) profiles across hospitals. However, given complexity FHIR...
Abstract Background Adequate sleep is of great importance in recovering from and preparing for training competition. Objective This study aimed to investigate subjective quality daytime sleepiness the German women’s junior national ice hockey team before after a camp immediately preceding World Championship Division IA tournament. Materials methods Twenty athletes (16.40 ± 0.68 years) completed paper–pencil versions Pittsburgh Sleep Quality Index (PSQI) Epworth Sleepiness Scale (ESS) (T1,...