A5050832506- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Genetic Associations and Epidemiology
- Neuroendocrine regulation and behavior
- Fatty Acid Research and Health
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Neurobiology and Insect Physiology Research
- Endoplasmic Reticulum Stress and Disease
- Advanced Chemical Sensor Technologies
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- Cardiovascular Disease and Adiposity
- Fibroblast Growth Factor Research
- Neuroscience of respiration and sleep
- Cancer-related gene regulation
- Diet and metabolism studies
Leipzig University
2014-2020
IFB Adiposity Diseases
2013-2019
DNA methylation plays an important role in obesity and related metabolic complications. We examined genome-wide promoter along with mRNA profiles paired samples of human subcutaneous adipose tissue (SAT) omental visceral (OVAT) from non-obese vs. obese individuals. identified negatively correlated expression several obesity-associated genes our discovery dataset silico replicated ETV6 two independent cohorts. Further, we six depot-specific (HAND2, HOXC6, PPARG, SORBS2, CD36, CLDN1). The...
Abstract Objective Adipose tissue–derived signals potentially link obesity and adipose tissue dysfunction with metabolic cardiovascular diseases. Although some adipocytokines have been closely related to traits, it is unknown which adipocytokine or clusters serve as meaningful markers of syndrome (MS) components. Therefore, this study investigated the associations 12 components MS identify most relevant cytokines specific profiles. Research Design Methods Twelve [adiponectin, adipocyte fatty...
Abstract The functional and metabolic characteristics of specific adipose tissue (AT) depots seem to be determined by intrinsic mechanisms. We performed a comprehensive transcriptome profiling human AT from distinct fat unravel their unique features potentially explaining molecular mechanisms underlying distribution contribution health disease. Post-mortem samples five body donors 15 anatomical locations were collected. Global mRNA expression was measured Illumina® Human HT-12 v4 Expression...
Background Genetic variants within the bitter taste receptor gene TAS2R38 are associated with sensitivity to and related eating behavior in Amish population. Sensitivity is further anthropometric traits an genetically isolated Italian We tested whether (rs713598; rs1726866 rs10246939) may be behavior, parameters, metabolic consumer goods intake German Sorbs. Materials Methods The three SNPs were genotyped a total cohort of 1007 individuals (male/female: 405/602). version three-factor...
Abstract Context Despite the emerging evidence on role of oxytocin (OXT) in metabolic diseases, there is a lack well-powered studies addressing relationship circulating OXT with obesity and diabetes. Objectives Design Here, we measured study cohort (n = 721; 396 women, 325 men; mean age ± SD, 47.7 15.2 years) subphenotypes related to obesity, including anthropometric traits such as body mass index [BMI (mean SD), 26.8 4.6 kg/m2], waist-to-hip ratio (WHR; 0.88 0.09), blood parameters...
Objective: The GRB14 locus (Growth Factor Receptor-Bound Protein 14) has been shown to be associated with waist hip ratio (WHR). To investigate possible mechanisms explaining the association, we assessed relationship between WHR-associated single nucleotide polymorphism (SNP) rs10195252, adipose tissue (AT) mRNA expression and metabolic traits related fat distribution (FD)
Aims: The Bone Morphogenetic Protein 2 (BMP-2) is a key player in the development of postnatal skeleton and may be involved regulation adipogenesis pancreatic ß-cell development. Our preliminary data show clear relationship between BMP2 traits related to obesity. However, genetic factors determining variability circulating levels are yet unknown. We therefore conducted genome-wide association study (GWAS) for serum BMP2.
Fragestellung: Die Fallkontrollstudie untersuchte Risikofaktoren für schwere Hypoglykämien (SH) bei Typ-1-Diabetikern.
Aims: Severe hypoglycaemia (SH) may increase cardiovascular and all-cause mortality in patients with long-standing complicated diabetes. We investigated whether T2DM who had experienced SH individual morbidity treatment targets sufficiently been respected.
Background and aims: Severe hypoglycemia (SH) is associated with a critical prognosis has acute life-threatening potential irrespective of diabetes type. Our aim was to highlight seasonal changes in SH patients type 1 (T1DM) 2 (T2DM) German population.