A5016039021- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- MicroRNA in disease regulation
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Dietary Effects on Health
- RNA modifications and cancer
- Regulation of Appetite and Obesity
- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- Hormonal Regulation and Hypertension
- Genetic Syndromes and Imprinting
- Cancer-related gene regulation
- Biochemical Analysis and Sensing Techniques
- Bariatric Surgery and Outcomes
- Pregnancy and Medication Impact
- Liver Disease Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Adrenal Hormones and Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Estrogen and related hormone effects
University Hospital Leipzig
2020-2025
Leipzig University
1998-2025
Helmholtz Zentrum München
2021-2025
Helmholtz Centre for Environmental Research
2023
IFB Adiposity Diseases
2013-2021
Lund University
2018-2021
University at Buffalo, State University of New York
2020
Skåne University Hospital
2018
Institute for Sports Medicine
2016
Offenburg University of Applied Sciences
2005
DNA methylation plays an important role in obesity and related metabolic complications. We examined genome-wide promoter along with mRNA profiles paired samples of human subcutaneous adipose tissue (SAT) omental visceral (OVAT) from non-obese vs. obese individuals. identified negatively correlated expression several obesity-associated genes our discovery dataset silico replicated ETV6 two independent cohorts. Further, we six depot-specific (HAND2, HOXC6, PPARG, SORBS2, CD36, CLDN1). The...
Abstract A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific therapies. Here we show that glucose-mediated changes gene expression largely persist diabetic kidney disease (DKD) despite reversing hyperglycemia. The senescence-associated cyclin-dependent kinase inhibitor p21 ( Cdkn1a ) was top hit among genes persistently induced by hyperglycemia and associated with induction of p53-p21 pathway. Persistent confirmed various animal models, human samples...
Epigenetic age is an estimator of biological based on DNA methylation; its discrepancy from chronologic warrants further investigation. We recently reported that greater polyphenol intake benefitted ectopic fats, brain function, and gut microbiota profile, corresponding with elevated urine polyphenols. The effect polyphenol-rich dietary interventions aging yet to be determined.We calculated different epigenetic clocks generations (Horvath2013, Hannum2013, Li2018, Horvath skin blood2018,...
<h2>Abstract</h2><h3>Background</h3> The capacity of a polyphenol-enriched diet to modulate the epigenome in vivo is partly unknown. Given beneficial metabolic effects Mediterranean (MED) enriched polyphenols and reduced red/processed meat (green-MED), as previously been proven by 18-month DIRECT PLUS randomized controlled trial, we analyzed green-MED on methylome transcriptome levels highlight molecular mechanisms underlying observed improvements. <h3>Methods</h3> Our study included 260...
Abstract Background One of the major challenges in obesity treatment is to explain high variability individual’s response specific dietary and physical activity interventions. With this study, we tested hypothesis that DNA methylation changes reflect individual responsiveness lifestyle intervention may serve as epigenetic predictors for a successful weight-loss. Methods We conducted an explorative genome-wide analysis blood samples from 120 subjects (90% men, mean ± SD age = 49 9 years, body...
Abstract Background DNA methylation age (mAge), a biomarker for the aging process, might serve as more accurate predictor of morbidity and status than chronological age. We evaluated role multiple factors, including fat deposition, cardiometabolic risk factors lifestyle weight-loss intervention, on deviation mAge from (mAge deviation) or 18-month change in (∆mAge). In this sub-study CENTRAL magnetic resonance imaging trial, we by validated 240-CpG-based prediction formula at baseline after...
Background Genetic variants within the bitter taste receptor gene TAS2R38 are associated with sensitivity to and related eating behavior in Amish population. Sensitivity is further anthropometric traits an genetically isolated Italian We tested whether (rs713598; rs1726866 rs10246939) may be behavior, parameters, metabolic consumer goods intake German Sorbs. Materials Methods The three SNPs were genotyped a total cohort of 1007 individuals (male/female: 405/602). version three-factor...
Abstract Objective Maternal hormonal status can have long-term effects on offspring metabolic health and is likely regulated via epigenetic mechanisms. We elucidated the of maternal thyroid hormones regulation leptin ( Lep ) transcription in adipose tissue (AT) subsequently investigated role DNA methylation at a upstream enhancer (UE) adipocyte biology. Results Pregnant mice treated with triiodothyronine (T3) produced reduced body weight, total fat mass, gonadal white (gWAT) mass 6 months...
ABSTRACT Aims Lifestyle‐induced weight loss (LIWL) is considered an effective therapy for the treatment of metabolic syndrome (MetS). The role differentially expressed genes (DEGs) in adipose tissue function and success LIWL MetS still unclear. We investigated effect 6 months on transcriptional regulation subcutaneous (SAT). Aiming to identify a LIWL‐associated “gene signature” SAT, DEGs were fitted into linear regression model. Materials Methods study embedded prospective, two‐arm,...
Human white adipose tissue (AT) is a metabolically active organ with distinct depot-specific functions. Despite their locations close to the gastrointestinal tract, mesenteric AT and epiploic (epiAT) have only scarcely been investigated. Here, we aim characterise these ATs in-depth estimate contribution alterations in whole-body metabolism.Mesenteric, epiploic, omental abdominal subcutaneous were collected from 70 patients obesity undergoing Roux-en-Y gastric bypass surgery. The...
Abstract Background and Aims In the CENTRAL trial context, we found diverse liver fat dynamics in response to different dietary interventions. Epigenetic mechanisms may contribute intraindividual variation. Moreover, genetic factors are involved developing nonalcoholic fatty‐liver disease (NAFLD), a reflected by an increase intrahepatic (IHF). this exploratory analysis, primarily aimed examine effect of lifestyle interventions on DNA‐methylation NAFLD related genes associated with IHF....