A5002161127- Cell Adhesion Molecules Research
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Chemokine receptors and signaling
- Advanced Glycation End Products research
- Pancreatic function and diabetes
- Caveolin-1 and cellular processes
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- Dietary Effects on Health
- Platelet Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Lipoproteins and Cardiovascular Health
- Bioinformatics and Genomic Networks
- Advanced Control Systems Design
- Endoplasmic Reticulum Stress and Disease
University of Luxembourg
2016-2025
Saarland University
2015-2025
Centre Hospitalier de Luxembourg
2017-2023
Universitätsklinikum des Saarlandes
2021-2023
Klinikum rechts der Isar
2018-2021
Technical University of Munich
2021
Shanghai Institute of Hematology
2018
Schneider Electric (France)
2014-2016
Heidelberg University
2001-2014
Luxembourg Institute of Socio-Economic Research
2014
The gastrointestinal microbiome is a complex ecosystem with functions that shape human health. Studying the relationship between taxonomic alterations and functional repercussions linked to disease remains challenging. Here, we present an integrative approach resolve attributes of microbiota at metagenomic, metatranscriptomic metaproteomic levels. We apply our methods samples from four families multiple cases type 1 diabetes mellitus (T1DM). Analysis intra- inter-individual variation...
Molecular events that result in loss of pain perception are poorly understood diabetic neuropathy. Our results show the receptor for advanced glycation end products (RAGE), a associated with sustained NF-kappaB activation microenvironment, has central role sensory neuronal dysfunction. In sural nerve biopsies, ligands RAGE, itself, activated NF-kappaBp65, and IL-6 colocalized microvasculature patients Activation NF-kappaB-dependent gene expression was upregulated peripheral nerves mice,...
Abstract Large-scale ‘meta-omic’ projects are greatly advancing our knowledge of the human microbiome and its specific role in governing health disease states. A myriad ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) diseases. However, due to inherent complexity heterogeneity microbiome, cross-sectional, case–control longitudinal may not have enough statistical power allow causation be deduced from patterns association variables high-resolution...
The hallmark of severe influenza virus infection is excessive inflammation the lungs. Platelets are activated during influenza, but their role in pathogenesis and inflammatory responses unknown.To determine platelets A infections propose new therapeutics against influenza.We used targeted gene deletion approaches pharmacologic interventions to investigate mice.Lungs infected mice were massively infiltrated by aggregates platelets. Platelet activation promoted pathogenesis. Activating...
Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze prevalence determinants bone mineral density (BMD) type 1 2 diabetes.Three hundred ninety-eight consecutive diabetic from a single outpatient clinic received standardized questionnaire on factors, were evaluated for diabetes-related complications, HbA1c levels, lumbar spine (LS) femoral neck (FN) BMD. Of these, 139 (71 men, 68 women) 243 (115 128 included the study. BMD...
Context:Primary macronodular adrenal hyperplasia (PMAH) is a rare cause of Cushing's syndrome, which may present in the context different familial multitumor syndromes. Heterozygous inactivating germline mutations armadillo repeat containing 5 (ARMC5) have very recently been described as for sporadic PMAH. Whether this genetic condition also causes PMAH association with other neoplasias unclear.
Twenty-three nondiabetic volunteers were divided into three groups. In group A (n = 9), the glucose infusion was adjusted to maintain blood at 5 mmol/l (euglycemic clamp). B 10 (hyperglycemic clamp) over 2 h. Group C consisted of five who studied as control group. Peripheral mononuclear cells (PBMCs) isolated before and end a 2-h clamp. C, PBMCs after h without performing The euglycemic clamp well “no clamp” had no effects on all parameters studied. contrast, significant increase in...
OBJECTIVE—Adiponectin is a plasma protein expressed in adipose tissue. Hypoadiponectinemia associated with low HDL cholesterol and high triglycerides, which also characterize lipoprotein lipase (LPL) deficiency syndromes. Recently, dramatically increased LPL activity was reported mice overexpressing adiponectin. We therefore speculated that adiponectin may directly affect humans. RESEARCH DESIGN AND METHODS—We measured postheparin 206 nondiabetic men second group of 110 patients type 2...
OBJECTIVE—Hepatic lipase plays a key role in hydrolyzing triglycerides and phospholipids present circulating plasma lipoproteins. Plasma hepatic activity is known to be regulated by several hormonal metabolic factors, but responsiveness insulin still controversial. Hypoadiponectinemia associated with resistance, diabetes, obesity. These conditions are often characterized high triglyceride low HDL cholesterol levels, they have been shown activity. We therefore raised the question whether...
Endothelial dysfunction leads to lethal vascular complications in diabetes and related metabolic disorders. Here, we demonstrate that de novo lipogenesis, an insulin-dependent process driven by the multifunctional enzyme fatty-acid synthase (FAS), maintains endothelial function targeting nitric-oxide (eNOS) plasma membrane. In mice with inactivation of FAS (FASTie mice), eNOS membrane content activity were decreased. physically associated; palmitoylation was decreased FAS-deficient cells,...
The adenosine diphosphate (ADP) receptor P2RY12 (purinergic P2Y, G protein coupled, 12) plays a critical role in platelet aggregation, and inhibitors are used clinically to prevent cardiac cerebral thrombotic events. Extracellular ADP has also been shown increase osteoclast (OC) activity, but the of OC biology is unknown. Here, we examined mouse function. Mice lacking P2ry12 had decreased activity were partially protected from age-associated bone loss. P2ry12-/- OCs exhibited intact...
// Christiane Margue 1 , Susanne Reinsbach 1,* Demetra Philippidou Nicolas Beaume Casandra Walters Jochen G. Schneider Dorothée Nashan 1,2 Iris Behrmann Stephanie Kreis Life Sciences Research Unit, University of Luxembourg, Luxembourg 2 Klinikum Dortmund GmbH, Germany * These authors have contributed equally to this work Correspondence to: Kreis, email: Keywords : serum/tissue samples, circulating miRNAs, healthy miRNome, miRNA qPCR arrays, melanoma biomarkers Received January 21, 2015...
Abstract Integrin β3 is critical for tumor invasion, neoangiogenesis, and inflammation, making it a promising cancer target. However, preclinical clinical data of integrin antagonists have demonstrated no benefit or worse outcomes. We hypothesized that could affect immunity evaluated tumors in mice with deletion macrophage lineage cells (β3KOM). β3KOM had increased melanoma breast growth tumor-promoting M2 macrophages decreased CD8+ T cells. antagonist, cilengitide, also enhanced function....
Hedgehog (Hh) signaling is implicated in bone development and cellular transformation. Here we show that inhibition of Hh pathway activity inhibits tumor growth through effects on the microenvironment. Pharmacologic effector Smoothened (Smo) increased trabecular vivo inhibited osteoclastogenesis vitro. In addition, enhanced due to heterozygosity inhibitory receptor Patched (Ptch1(+/-)) resorption, suggesting direct regulation osteoclast (OC) by pathway. Ptch1(+/-) mice had metastatic...
Fatty acid metabolism is perturbed in atherosclerotic lesions, but whether it affects lesion formation unknown. To determine fatty synthesis atherosclerosis, we inactivated fatty-acid synthase (FAS) macrophages of apoE-deficient mice. Serum lipids, body weight, and glucose were the same FAS knock-out (FASKOM) control mice, blood pressure was lower FASKOM animals. Atherosclerotic extent decreased 20-40% different aortic regions as compared with mice on Western diets. Foam cell diminished wild...
Common variants of about 20 genes contributing to AD risk have so far been identified through genome-wide association studies (GWAS). However, there is still a large proportion heritability that might be explained by rare but functionally important variants. One the with causing ADAM10. Using whole-genome sequencing we now single nonsynonymous variant (SNV) rs142946965 [p.R215I] in ADAM17 co-segregating an autosomal-dominant pattern late-onset one family. Subsequent genotyping and analysis...
The oncogene DJ-1 has been originally identified as a suppressor of PTEN. Further on, loss-of-function mutations have described causative factor in Parkinson's disease (PD). an important function cellular antioxidant responses, but its role central metabolism neurons is still elusive. We applied stable isotope assisted metabolic profiling to investigate the effect functional loss and show that deficient neuronal cells exhibit decreased glutamine influx reduced serine biosynthesis. By...