A5101436478- Advanced Glycation End Products research
- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Diabetes and associated disorders
- Pain Mechanisms and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Diabetes Management and Research
- Congenital Heart Disease Studies
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Glioma Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Lipoproteins and Cardiovascular Health
- Wound Healing and Treatments
- Pulmonary Hypertension Research and Treatments
- Vascular anomalies and interventions
- Biochemical effects in animals
- Teleoperation and Haptic Systems
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pituitary Gland Disorders and Treatments
- Mesenchymal stem cell research
University of Maryland, College Park
2025
Heidelberg University
2005-2024
Universidad Autónoma de Nuevo León
2024
Hospital Universitario Dr José Eleuterio Gonzalez
2024
University Medical Centre Mannheim
2024
University Hospital Heidelberg
2004-2024
University of Washington
2009-2021
Fuchs (Germany)
2016-2020
University of Washington Medical Center
2018
Chase Farm Hospital
2011
Activation of the transcription factor nuclear factor-κB (NF-κB) has been suggested to participate in chronic disorders, such as diabetes and its complications. In contrast short transient activation NF-κB vitro, we observed a long-lasting sustained absence decreased IκBα mononuclear cells from patients with type 1 diabetes. This was associated increased NF-κBp65. A comparable increase NF-κBp65 antigen mRNA also vascular endothelial diabetic rats. As mechanism, propose that binding ligands...
OBJECTIVE The redox-sensitive transcription factor nuclear factor-kB (NF-kB) is believed to contribute late diabetic complications. It unknown whether NF-kB influenced by glycemic control. RESEARCH DESIGN AND METHODS To determine activated in patients with insufficient control (HbA1c > 10%), we developed a tissue culture-independent electrophoretic mobility shift assay (EMSA)-based semiquantitative detection system that allowed us activation ex vivo-isolated peripheral blood...
OBJECTIVE—Adiponectin is a plasma protein expressed in adipose tissue. Hypoadiponectinemia associated with low HDL cholesterol and high triglycerides, which also characterize lipoprotein lipase (LPL) deficiency syndromes. Recently, dramatically increased LPL activity was reported mice overexpressing adiponectin. We therefore speculated that adiponectin may directly affect humans. RESEARCH DESIGN AND METHODS—We measured postheparin 206 nondiabetic men second group of 110 patients type 2...
Dipeptidyl peptidase 4 (DPP4) inhibitors improve glycemic control in type 2 diabetes, however, their influence on the retinal neurovascular unit remains unclear.Vasculo- and neuroprotective effects were assessed experimental diabetic retinopathy high glucose-cultivated C. elegans, respectively. In STZ-diabetic Wistar rats (diabetes duration of 24 weeks), DPP4 activity (fluorometric assay), GLP-1 (ELISA), methylglyoxal (LC-MS/MS), acellular capillaries pericytes (quantitative morphometry),...
Owing to the rarity of adrenocortical carcinoma (ACC) no prognostic markers have been established beyond stage and resection status. Accelerated glycolysis is a characteristic feature cancer cells in variety tumour entities key factors glucose metabolism like transporter 1 3 (GLUT1 -3), transketolase like-1 enzyme (TKTL1) pyruvate kinase type M2 (M2-PK) are overexpressed value. Therefore, we investigated role these ACC. Immunohistochemical analysis was performed on tissue microarrays...
We studied the association between polymorphisms in UCP genes and diabetes complications patients with type 1 diabetes.We analyzed 227 using PCR subsequent cleavage by restriction endonucleases for promoter variants A-3826G UCP1 gene, G-866A UCP2 C-55T UCP3 gene.No effect of polymorphism gene on was found. Patients who were heterozygous or homozygous had a significantly reduced prevalence diabetic neuropathy (UCP2: odds ratio 0.44 [95% CI 0.24-0.79], P = 0.007; UCP3: 0.48 [0.25-0.92],...
OBJECTIVE Markers reliably identifying vascular damage and risk in diabetic patients are rare, reports on associations of serum adiponectin with macrovascular disease have been inconsistent. In contrast to existing data adiponectin, this study assesses whether urinary excretion might represent a more consistent marker type 2 diabetes. RESEARCH DESIGN AND METHODS Adiponectin distribution human kidney biopsies was assessed by immunohistochemistry, isoforms were characterized Western blot...
Current guidelines for the treatment of type 2 diabetes focus on pharmacological glucose and cardio-vascular risk factors. The aim this prospective randomized controlled intervention study was to examine effects a psychosocial clinical endpoints factors in patients with early diabetic kidney disease. 110 were receive an 8-week mindfulness-based stress reduction (MBSR) training (n=53) compared standard care (n=57). carried out open-labelled randomization performed computer-generated 1:1...
This paper illustrates the development, implementation, and testing of full-body haptic spatial audio cueing algorithms for augmented pilot perception, where is based on localized electrical muscle stimulation. Cueing are developed roll-axis compensatory tracking tasks acts displayed error between a desired input comparable vehicle output motion to produce control action. The using multiple modalities: visual, haptic, audio, combinations these. For visual combined haptic/audio modalities,...
CD34+/CD133+ circulating adult progenitor cells (PCs) play an important role in tissue repair metabolic disease. PCs have a certain plasticity to differentiate into with tissue-specific phenotypes (1–3). In diabetic mice, therapeutic use of models hindlimb ischemia and wound healing was particularly effective, suggesting diabetes-dependent defect PC function (4,5). Accordingly, vitro outgrowth angiogenic endothelial differentiating from (1) is diminished patients cardiovascular risk factors...
The initial phase of wound repair involves inflammation, induction tissue factor (TF), formation a fibrin matrix, and growth new smooth muscle actin (α-SMA)-positive vessels. In diabetes, TF in response to cutaneous wounding, which ordinarily precedes increased expression vascular endothelial (VEGF) α-SMA transcription, is diminished, though not degree causing excessive local bleeding. Enhanced wounds diabetic mice caused by somatic gene transfer VEGF transcription translation and,...
Epidermal growth factor receptor 1 (EGFR-1) overexpression is usually described as linked with a worse prognosis in variety of tumours epithelial origin. However, its role ovarian cancer still controversial. The aim the present study was to analyse prognostic impact EGFR-1 retrospective series 93 stage III–IV primary tumours. All patients, enrolled multicentre GINECO prospective clinical trial, were treated same platinum-based combination chemotherapy, and followed up median 69 months....
Experimental animal models have demonstrated that the interaction of advanced glycation end-products (AGE) with their receptor RAGE is, at least in part, responsible for peritoneal damage. This study investigates vivo expression membrane uraemic human patients.Peritoneal biopsies 89 subjects (48 and 41 healthy age-matched patients) were examined. The CD3, IL-6, activated NFkappaBp65, VEGF, transforming growth factor (TGF)-beta1, smooth-muscle actin (SMA), methylglyoxal (MGO) was analysed...
The receptor for glycation end-products RAGE was previously shown to play a central role in the development of diabetic neuropathy. present study aimed investigate, whether plasma levels soluble forms are associated with neuropathy type 2 diabetes. One-hundred and eight patients were screened peripheral autonomic using standardized screening tests. No differences or more defined endogenous secretory observed categorized into having no, mild, moderate, severe deficits disability symptom...
Liraglutide and linagliptin are novel drugs for the treatment of diabetes. Antioxidative neuroprotective effects have been described both compounds. However, it is not yet known, whether these mechanisms also protective against diabetic retinal neurodegeneration. We assessed antioxidative capabilities liraglutide as well signaling pathways involved, by using <i>C. elegans</i> a model glucose-induced were cultivated under conditions, which mimic clinical hyperglycemia, treated with 160 μmol/l...
Several polymorphisms have been identified in the RAGE-promoter region that might modulate outcome of disease. Here we analyse association a 63bp deletion (delta63) spanning from bp - 407 to 345 with diabetic nephropathy.
Aim: β‐adrenergic receptors (β‐ARs) are of key importance for the regulation lipolysis and thermogenesis by catecholamines. Genetic defects in expression or function β 1 ‐ 2 and/or 3 ‐AR could affect energy homeostasis predispose an individual towards development obesity. We therefore investigated possible association polymorphisms receptor genes with early onset Methods: Frequencies following variants were assessed extremely obese children healthy underweight controls: Gly/Ser codon 49...
Molecular events that result in loss of pain perception are poorly understood diabetic neuropathy. Our results show the receptor for advanced glycation end products (RAGE), a associated with sustained NF-κB activation microenvironment, has central role sensory neuronal dysfunction. In sural nerve biopsies, ligands RAGE, itself, activated NF-κBp65, and IL-6 colocalized microvasculature patients Activation NF-κB–dependent gene expression was upregulated peripheral nerves mice, induced by...