A5051463578- Dental Implant Techniques and Outcomes
- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Dental Radiography and Imaging
- Orthopaedic implants and arthroplasty
- Dental materials and restorations
- Orthodontics and Dentofacial Orthopedics
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Bone Metabolism and Diseases
- Temporomandibular Joint Disorders
- Mesenchymal stem cell research
- Cleft Lip and Palate Research
- Bone health and osteoporosis research
- RNA modifications and cancer
- dental development and anomalies
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Reconstructive Surgery and Microvascular Techniques
- Bone health and treatments
- Polymer Surface Interaction Studies
- Dental Trauma and Treatments
- Medical Imaging and Analysis
- Salivary Gland Disorders and Functions
- Bone and Dental Protein Studies
Fujian Medical University
2016-2025
Xiangya Hospital Central South University
2013-2025
Central South University
2012-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2025
Shanghai Jiao Tong University
2012-2025
Fudan University
2025
State Key Laboratory of Medical Neurobiology
2025
First Affiliated Hospital of Fujian Medical University
2025
General Hospital of Shenyang Military Region
2025
Renji Hospital
2011-2025
Abstract Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma (HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and mechanisms underlying have not been fully clarified. Here we report that a circular RNA, circRNA-SORE (a RNA upregulated in so rafenib- re sistant HCC cells), plays significant role HCC. We found sorafenib-resistant cells depletion of substantially increases cell-killing ability sorafenib. Further studies...
Dysregulation of microRNA (miRNA) biogenesis is implicated in cancer development and progression. Dicer Drosha are established regulators miRNA biogenesis. In this study, we used a array to evaluate the expression profiles nasopharyngeal carcinoma (NPC) samples. The significance analysis microarrays showed global downregulation NPC samples compared with normal epithelial tissues. Notably, miR-18a, member oncogenic miR-17–92 cluster, was upregulated ell lines. Clinical parameter studies that...
Binary titanium-niobium (Ti-Nb) alloys have recently been attracted due to low Young's moduli and non-toxic properties. This study explores the influence of Nb content (0-25 wt%) on comprehensive parameters tensile stress-strain relationships (ultimate strength (σUTS), yield (σ0.2) elastic modulus (E)), surfaces properties (Vickers microhardness, surface roughness (Ra), water contact angle (WCA), X-ray diffraction (XRD) scanning electron microscopy (SEM)), corrosion resistance (in artificial...
To compare the accuracy of dynamic navigation (DN) with a static surgical guide (SSG) for dental implant placement and influence factors such as experience surgeon sites.A total 38 implants, which underwent navigation, 57 implants were enrolled in retrospective study. Coronal deviation, apical angular deviation compared between DN SSG groups, along different level surgeons sites group.There no statistically significant differences group. However, was slightly higher than group anterior teeth...
This study aims to compare the surgical efficiency (preparation and operation time) accuracy of implant placement between robots with different human-robot interactions.The were divided into three groups: semi-active robot (SR), active (AR) passive (PR). Each placed two implants (#31 #36) on a phantom, practising 10 times. The then evaluated.Sixty in 30 phantoms. mean preparation times for AR, PR SR groups 3.85 ± 0.17 min, 2.14 0.06 mins 1.65 0.19 mins, respectively. time group (3.76 0.59...
This study assessed the accuracy of robotic computer-aided implant surgery (rCAIS) in partially edentulous patients using a standard operation procedure. Patients who underwent placement surgeries system under procedure were recruited. Deviations dental implants calculated after superimposition preoperative and postoperative cone-beam computed tomography (CBCT) images. The possible effects regions on these deviations investigated. A total 30 participants enrolled 44 inserted. median...
Osteoporosis is known to impair the process of implant osseointegration. The recent discovery that statins (HMG-CoA reductase inhibitors) act as bone anabolic agents suggests can be used potential in treatment osteoporosis. Therefore, we hypothesized will promote osteogenesis around titanium implants subjects with osteoporosis.Fifty-four female Sprague Dawley rats, aged 3 months old, were randomly divided into three groups: Sham-operated group (SHAM; n=18), ovariectomized (OVX; and...
MicroRNAs (miRNAs) are small non-coding RNAs that participate in the spatiotemporal regulation of messenger RNA (mRNA) and protein synthesis. Recent studies have shown some miRNAs involved progression nasopharyngeal carcinoma (NPC). However, aberrant implicated different clinical stages NPC remain unknown their functions not been systematically studied.In this study, miRNA microarray assay was performed on biopsies from NPC. TargetScan used to predict target genes miRNAs. The gene list...
Uncontrollable bleeding and bacterial infection are the two major challenges in treating hemorrhaging civilian military traumas. Herein, a novel hemostatic material was designed by situ growth of zinc imidazolate frameworks (ZIF-8) into chitin sponge (CTS) for effective hemostasis anti-infection. ZIF-8 nanocrystals were not only uniformly dispersed throughout CTS but also firmly anchored onto with residual mass over 94% after 10 min sonication. The resultant composite (ZIF-8–CTS) displayed...
Currently, the classification of bone mineral density (BMD) in many research studies remains rather broad, often neglecting localized changes BMD. This study aims to explore correlation between peri-implant BMD and primary implant stability using a new artificial intelligence (AI)-based grading system. 49 patients who received dental treatment at Affiliated Hospital Stomatology Fujian Medical University were included. Recorded quotient (ISQ) after implantation insertion torque value (ITV). A...
Bone marrow-derived mesenchymal stem cells (BMSCs, also known as bone stromal cells) are to be a component of the tumor microenvironment. BMSCs multipotent that can differentiate into variety cell types, including osteocytes, chondrocytes, adipocytes, epithelial and endothelial cells. Stem found in niches or transplanted injured tissues constantly encounter hypoxic stress. Areas with very low no oxygen pressure exist solid tumors. The differentiation capacity under conditions remains...
Lactic acid bacteria (LAB) are the most frequently encountered beer-spoilage bacteria, and they can render beer undrinkable owing to production of lactic acid, diacetyl turbidity. Three strains, 2011–6, 2011–8 2011–11, were isolated from finished beers. Based on 16S rRNA sequence analysis, these three isolates identified as Lactobacillus acetotolerans. Only horA homologue was detected in while horC not detected. In addition, an improved plate culture method for rapid detection LAB by...
Due to the rising demand for zirconia (Zr) based implant systems, it is important understand impact of Zr and titanium (Ti) implants particularly their topography on soft tissue healing. As human gingival fibroblasts (hGFs) are predominant cells in peri-implant tissue, we focused examining effect material surface roughness hGFs’ initial attachment, growth expression proteins involved focal adhesion. hGFs isolated from eight healthy donors were cultured following surfaces: smooth machined...
Abstract Background Dynamic navigation systems have a broad application prospect in digital implanting field. This study aimed to explore and compare the dynamic system learning curve of dentists with different implant surgery experience through dental models. Methods The nine participants from same hospital were divided equally into three groups. Group 1 (G1) 2 (G2) who had more than 5 years experience. G1 also 3 navigation, while G2 no navigation. (G3) consisted Each participant...
Abstract Objective Optimal implant planning and placement allows the prosthesis to be well designed achieve a satisfactory aesthetic functional outcome. We aimed compare deviations between with assistance of dynamic computer‐assisted surgery (d‐CAIS) or autonomous robotic (r‐CAIS) methods in clinical setting. Methods The retrospective analysis medical records 2021 July 2022 December was conducted implantation accuracy d‐CAIS r‐CAIS system partially edentulous patients through cone‐beam...
Abstract Computer-aided implant surgery has undergone continuous development in recent years. In this study, active and passive systems of dynamic navigation were divided into system group (ADG PDG), respectively. Active, semi-active robots robot group, (ARG, PRG SRG), Each placed two implants (FDI tooth positions 31 36) a model 12 times. The accuracy 216 108 models analysed. coronal deviations ADG, PDG, ARG, SRG 0.85 ± 0.17 mm, 1.05 0.42 0.29 0.15 0.40 0.16 mm 0.33 0.14 apical the five...
Serum is one of the most commonly used biofluids for biomarker exploration. Some studies examine serum directly, while others focus on specific components like small extracellular vesicles (sEVs), which are lipid-bilayer encapsulated particles carrying a variety molecular cargos. However, diagnostic value sEVs versus sEVs-depleted fractions (EV-free serum) early cancer detection unclear. In study, size exclusion chromatography (SEC) employed to separate from prostate (PCa) suspects into...
Radiation enteritis is a common complication of radiation therapy in which the surrounding normal intestinal tissue damaged by ionising radiation, and there no standard pharmacological prophylaxis or treatment regimen available. Mesenchymal stem cell transplantation can be used for protection acute injury, but its therapeutic mechanism action remains unclear. To investigate protective effects autologous bone marrow-derived mesenchymal (ABMSC) on radiation-induced injury. A model radioactive...
Futian Mangrove Nature Reserve is a vital habitat for birds in Shenzhen city of China, and the diversity bird species considerable concern. Traditional surveys depend on direct observation expert assessment, necessitating significant manpower tracking. This study utilized environmental DNA metabarcoding technology to gather 128 samples water, soil, air, along with feces feathers collected during summer winter 2023. A total 72 operational taxonomic units (OTUs) were identified. The results...