A5100776843- Dental Implant Techniques and Outcomes
- Complement system in diseases
- Immune Cell Function and Interaction
- Periodontal Regeneration and Treatments
- Dental Radiography and Imaging
- Bone Tissue Engineering Materials
- Dental Trauma and Treatments
- Immune Response and Inflammation
- interferon and immune responses
- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Orthopaedic implants and arthroplasty
- Blood Coagulation and Thrombosis Mechanisms
- Bone Metabolism and Diseases
- Platelet Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Blood groups and transfusion
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Galectins and Cancer Biology
- Birth, Development, and Health
- Dental Research and COVID-19
- Antimicrobial Peptides and Activities
- Erythrocyte Function and Pathophysiology
University of Groningen
2025
Fujian Medical University
2015-2024
Xidian University
2023
Air Force Engineering University
2023
Changhai Hospital
2006-2021
Second Military Medical University
2006-2021
Tongji University
2015-2020
Tongji Hospital
2015-2020
Blood Center of Zhejiang Province
2020
University of Pennsylvania
2007-2019
The newly identified type III interferon (IFN-lambda) has antiviral activity against a broad spectrum of viruses. We thus examined whether IFN-lambda the ability to inhibit human immunodeficiency virus 1 (HIV-1) infection blood monocyte-derived macrophages that expressed receptors. Both IFN-lambda1 and IFN-lambda2, when added macrophage cultures, inhibited HIV-1 replication. This IFN-lambda-mediated anti-HIV-1 is broad, as could by both laboratory-adapted clinical strains HIV-1....
Summary Primary biliary cirrhosis (PBC) is an organ-specific autoimmune liver disease characterized by progressive loss of intrahepatic small bile ducts. Cellular immune mechanisms involving T cell reaction are thought to be involved significantly in the pathogenesis PBC. Recent studies have independently revealed enhanced helper type 17 (Th17) response and weakened regulatory (Treg) some diseases, indicating a role Th17/Treg imbalance autoimmunity. This prompted us investigate whether...
Background Exercise is a major nonpharmacological treatment for hypertension, but its underlying mechanisms are still not completely elucidated. Irisin, polypeptide containing 112 amino acids, which secreted mainly by skeletal muscle cells during exercise, exerts protective role in metabolic diseases, such as diabetes mellitus and obesity. Because of the close relationship between irisin we hypothesized that may play regulation blood pressure. Methods Results Blood pressures male...
To compare the accuracy of dynamic navigation (DN) with a static surgical guide (SSG) for dental implant placement and influence factors such as experience surgeon sites.A total 38 implants, which underwent navigation, 57 implants were enrolled in retrospective study. Coronal deviation, apical angular deviation compared between DN SSG groups, along different level surgeons sites group.There no statistically significant differences group. However, was slightly higher than group anterior teeth...
This study aims to compare the surgical efficiency (preparation and operation time) accuracy of implant placement between robots with different human-robot interactions.The were divided into three groups: semi-active robot (SR), active (AR) passive (PR). Each placed two implants (#31 #36) on a phantom, practising 10 times. The then evaluated.Sixty in 30 phantoms. mean preparation times for AR, PR SR groups 3.85 ± 0.17 min, 2.14 0.06 mins 1.65 0.19 mins, respectively. time group (3.76 0.59...
Factor H (fH) and properdin both modulate complement; however, fH inhibits activation, promotes activation of the alternative pathway complement. Mutations in associate with several human kidney diseases, but whether inhibiting would be beneficial these diseases is unknown. Here, we found that either genetic or pharmacological blockade properdin, which expected to therapeutic, converted mild C3 GN an fH-mutant mouse a lethal features dense deposit disease. We attributed this phenotypic...
Currently, the classification of bone mineral density (BMD) in many research studies remains rather broad, often neglecting localized changes BMD. This study aims to explore correlation between peri-implant BMD and primary implant stability using a new artificial intelligence (AI)-based grading system. 49 patients who received dental treatment at Affiliated Hospital Stomatology Fujian Medical University were included. Recorded quotient (ISQ) after implantation insertion torque value (ITV). A...
Herpes simplex virus Type I (HSV-1) is a neurotropic that capable of infecting not only neurons, but also microglia and astrocytes can establish latent infection in the central nervous system (CNS). We investigated whether IFN lambda (IFN-λ), newly identified member family, has ability to inhibit HSV-1 primary human neurons. Both neurons were found be highly susceptible infection. However, upon IFN-λ treatment, replication both was significantly suppressed, which evidenced by reduced...
The alternative pathway (AP) of complement activation is constitutively active and must be regulated by host proteins to prevent autologous tissue injury. Dysfunction AP regulatory has been linked several human inflammatory disorders. Properdin a positive regulator that shown extend the half-life cell surface–bound C3 convertase C3bBb; it may also initiate activation. Here, we demonstrate critical role for properdin in injury mediated We identified myeloid lineage cells as principal source...
Abstract C5aR is a G protein-coupled receptor for the anaphylatoxin C5a and mediates many proinflammatory reactions. signaling also has been shown to regulate T cell immunity, but its sites mechanism of action in this process remain uncertain. In study, we created GFP knockin mouse used as surrogate marker examine expression. was knocked into 3′-untranslated region C5ar1 by gene targeting. We show that expressed highly on Gr-1+CD11b+ cells blood, spleen, bone marrow moderately CD11b+F4/80+...
Abstract Background Dynamic navigation systems have a broad application prospect in digital implanting field. This study aimed to explore and compare the dynamic system learning curve of dentists with different implant surgery experience through dental models. Methods The nine participants from same hospital were divided equally into three groups. Group 1 (G1) 2 (G2) who had more than 5 years experience. G1 also 3 navigation, while G2 no navigation. (G3) consisted Each participant...
Abstract Toll‐like receptors (TLRs) play an essential role in initiating intracellular type I interferon (IFN)‐mediated innate immunity against viral infections. We examined whether human neuronal cells (primary neurons, NT2‐N and CHP‐212 cells) express TLRs mount IFN‐mediated herpes simplex virus‐1 (HSV‐1) infection. Human expressed TLR family members 1–10 IFN‐α/β. The activation of TLR3 or TLR8 by double‐stranded RNA (poly‐I:C) single‐stranded (ssRNA) induced IFN‐α/β expression. In...
Abstract B-cell infection by hepatitis C virus (HCV) has been a controversial topic. To examine whether HCV genetically determined lymphotropism through co-receptor specific for the lymphotropic HCV, we established an infectious clone and chimeric of hepatotropic strains derived from HCV-positive lymphoma. The viral envelope 5′-UTR sequences strain were responsible lymphotropism. Silencing sensor, RIGI, or overexpression microRNA-122 promoted persistent replication in B cells. By cDNA...
Summary Background Memory T cells, a highly effective subset of lymphocytes, have been reported to be involved in many inflammatory skin disorders. However, the potential role memory cells keloid disease (KD) remains unclear. Objectives Due their important regulating inflammation, we investigated characteristics CD45RO+ KD. Methods Primary cutaneous were isolated from scars and normal by enzymic digestion. Peripheral blood mononuclear related sample, flow cytometry was applied identify...
Abstract Background The aim of the study was to compare efficacy autogenous tooth bone and xenogenic grafted in immediate implant placement with defect. Methods Thirty patients whose compromised anterior teeth need were enrolled. Autogenous made from extracted by chair-side or used repaired Clinical examination, radiographic assessment about horizontal change level 0 mm, 3 mm 6 below neck marginal loss immediately, 12 months after placement. Questionnaire feelings surgery at time removing...
CD56+ T cells are abundant in liver and play an important role defense against viral infections. However, the of control hepatitis C virus (HCV) infection remains to be determined. We investigated noncytolytic anti-HCV activity primary human hepatocytes. When HCV Japanese fulminant hepatitis-1 (JFH-1)–infected hepatocytes were co-cultured with or incubated media conditioned cell culture supernatants (SN), infectivity replication significantly inhibited. The antibodies interferon (IFN)-γ...