A5101406098- Viral Infections and Vectors
- Fire effects on ecosystems
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Respiratory viral infections research
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Immune Cell Function and Interaction
- interferon and immune responses
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Herpesvirus Infections and Treatments
- Tea Polyphenols and Effects
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Microbial infections and disease research
- Pneumonia and Respiratory Infections
- Pluripotent Stem Cells Research
Wuhan Institute of Virology
2008-2023
Wuhan University
2009-2023
Weatherford College
2021
State Key Laboratory of Virology
2012-2014
Institute of Virology of the Slovak Academy of Sciences
2012
The University of Texas Medical Branch at Galveston
2005
University of Michigan–Ann Arbor
1994
The newly identified type III interferon (IFN-lambda) has antiviral activity against a broad spectrum of viruses. We thus examined whether IFN-lambda the ability to inhibit human immunodeficiency virus 1 (HIV-1) infection blood monocyte-derived macrophages that expressed receptors. Both IFN-lambda1 and IFN-lambda2, when added macrophage cultures, inhibited HIV-1 replication. This IFN-lambda-mediated anti-HIV-1 is broad, as could by both laboratory-adapted clinical strains HIV-1....
To clarify the effect of aspirin on mortality and viral duration in adults infected with respiratory syndrome coronavirus 2 (SARS-Cov-2).After propensity score-matched (PSM) case-control analyses 24 pairs patients were enrolled followed up for months. Both 30-day 60-day group significantly lower than that non-aspirin (P = .021 P .030, respectively). The time between groups was not different .942).Among (with hypertension, cardiovascular diseases) SARS-Cov-2, low-dose medication (100 mg/day)...
The wide circulation of novel avian influenza viruses (AIVs) highlights the risk pandemic emergence in China. To investigate prevalence and genetic diversity AIVs different ecological contexts, we surveyed live poultry markets (LPMs), free-range wetland habitats wild birds Zhejiang Hubei provinces. Notably, LPMs contained highest frequency AIV infection, greatest number subtypes (n = 9) subtype co-infections 14), as well frequent reassortment, suggesting that they play an active role...
Abstract During the 2004 surveillance of rotaviruses in Wuhan, China, a G4P[6] rotavirus strain R479 was isolated from stool specimen collected 2‐year‐old child with diarrhea. The had an uncommon subgroup specificity I + II, and analysis VP6 gene suggested that it related to porcine rotaviruses. In present study, full‐length nucleotide sequences all RNA segments were determined analyzed phylogenetically identify origin individual segments. According genotyping system based on 11 segments,...
Background Hemorrhagic fever with renal syndrome (HFRS) is caused by different hantaviruses within the Bunyaviridae family. HFRS a fulminant, infectious disease that occurs worldwide and endemic in all 31 provinces of China. Since first case Hubei Province was reported 1957, has spread across province become one seriously affected areas China greatest number cases 1980's. However, epidemic characteristics are still not entirely clear long-term, systematic investigations this area have been...
Viruses in the Phlebovirus genus of family Bunyaviridae cause clinical syndromes ranging from a short, self-limiting febrile illness to fatal haemorrhagic fever. The currently consists 68 antigenically distinct virus serotypes, most which have not been genetically characterized. RT-PCR with four 'cocktail' primers was performed amplify region M segment genome 24 phleboviruses included sandfly fever Naples, Sicilian and Punta Toro serocomplexes. Partial sequences were successfully obtained...
BACKGROUND:At present, whether human cytomegalovirus (HCMV) infection is associated with type 2 diabetes mellitus (T2DM) debatable. The effect of active HCMV on glucose regulation has been poorly studied. Although correlated atherosclerosis in cardiovascular disease, the role development diabetic T2DM unclear and usually neglected by endocrinologists. aim this study was to assess effects patients. MATERIAL AND METHODS:A total 222 hospitalized patients were enrolled. Nested polymerase chain...
Hemorrhagic fever with renal syndrome (HFRS) is considered a globally distributed infectious disease which results in many deaths annually Hubei Province, China. In order to conduct better analysis and accurately predict HFRS incidence new model named Seasonal Difference-Geographically Temporally Weighted Regression (SD-GTWR) was constructed. The SD-GTWR model, integrates the relationship of seasonal difference, spatial temporal characteristics (HFRS characterized by spatiotemporal...
Coxsackievirus B(3)(CVB(3)) infection is the major cause of viral myocarditis, as well dilated cardiomypathy. Rhubarb one oldest and best-known traditional Chinese medicines. We initiated this study to determine antiviral effect an ethanol extract from roots rhizoma Rheum palmatum (R. palmatum, Rhubarbs), against CVB(3) in tissue culture cells a mouse model. The R. showed significant inhibitory activity on HEp-2 when added after infection, with IC(50) 4 μg/ml, TI 10. medicated serum still...
Multiple strains infection of human cytomegalovirus (HCMV) was found to be correlated with increased viral load in immunodeficient patients. However, the pathogenic mechanism underlying this correlation remains unclear. To evaluate genetic polymorphisms HCMV glycoprotein and their potential role its load, B, N, O (gB, gN gO) genotypes studied population infected acquired immune deficiency syndrome (AIDS) The association between analyzed.The from sera 60 AIDS patients investigated by...
Recent studies have shown that West Nile virus (WNV) can induce an asymptomatic persistent infection in the kidneys of experimentally infected hamsters. The chronically rodents shed their urine for up to 8 months, despite disappearance viremia and development high levels neutralizing antibodies. WNV, like most members Japanese encephalitis complex ( Flavivirus; Flaviviridae), is assumed be mainly neurotropic; little known about genetic basis its renal tropism. In this study, complete...
Herpes simplex virus 1 (HSV-1) is one of the most prevalent human pathogens in both industrialized and developing countries. This study was performed to analyze antiviral activity purified flavonoid from Polygonum perfoliatum L. against HSV-1 infection vitro vivo. Flavonoid showed no inhibitory effect, when treated before infection, but it strongly inhibited viral replication cell-to-cell spread which vital for virus's propagation. The therapeutic effect treating induced encephalitis also...
This study was sought to investigate the propagation and morphogenesis of a new strain hantavirus, HV114.The urine patient with epidemic hemorrhagic fever inoculated Vero E6 cells for virus isolation. Electron microscopy used observe isolated virus, HV114 variation infected cells.According our observations, size (90-120 nm) is smaller than that reported previously as 110- 160 nm. While ribosome-like particles associated virions originating from rodent hantaviruses were not observed in HV114,...