A5087630735- Analytical Chemistry and Chromatography
- Chromatography in Natural Products
- Chronic Myeloid Leukemia Treatments
- Plant-based Medicinal Research
- 3D Printing in Biomedical Research
- Hormonal and reproductive studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Protein purification and stability
- Natural product bioactivities and synthesis
- Toxin Mechanisms and Immunotoxins
- Plant Toxicity and Pharmacological Properties
- Monoclonal and Polyclonal Antibodies Research
- Radical Photochemical Reactions
- Traditional Chinese Medicine Analysis
- Genomics, phytochemicals, and oxidative stress
- Medicinal plant effects and applications
- Phytochemical compounds biological activities
- Magnolia and Illicium research
- Mass Spectrometry Techniques and Applications
- Silymarin and Mushroom Poisoning
- Pesticide Residue Analysis and Safety
- Protease and Inhibitor Mechanisms
- Quinazolinone synthesis and applications
- Alkaloids: synthesis and pharmacology
- Herpesvirus Infections and Treatments
Xi'an Jiaotong University
2012-2024
Jinan University
2024
Central South University
2018
Third Xiangya Hospital
2018
China XD Group (China)
2015
Hubei University of Chinese Medicine
2014
Peking University
2006
University of Florida
2002
Progression of Benign Prostate hyperplasia (BPH) is vulnerable to oxidative stress (OS) and prostatic enlargement among the aging males through apoptosis deregulation. Our present study aimed investigate effect neferine (NF) in regulation human BPH-1 cells.BPH epithelial cell line was treated with NF for 24 48 h. To measure we investigated MDA, SOD, GST expression along Nrf2 its downstream gene protein expression. Cell proliferation assayed respective methods.Investigation revealed...
In this study, highly selective core–shell molecularly imprinted polymers on the surface of magnetic nanoparticles were prepared using protocatechuic acid as template molecule. The resulting characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, and vibrating sample magnetometry. binding performances materials evaluated static adsorption. isotherms obtained for fitted Langmuir isotherm model Freundlich model. Furthermore, used...
Agrimony is a traditional Chinese medicine and herb of Agrimonia pilosa Ledeb belonging to the Rosaceae family. Many pharmacological effects agrimony have been demonstrated in previous studies. Few studies screened active compounds this complex product for chronic prostatitis. In study, two dimensional online method was established. A Sprague-Dawley (SD) rat prostate CMC-online-HPLC/MS used screen, analyze, identify acting on α1 adrenergic receptor from agrimony. Via agrimonolide screened,...
Forty-two compounds with flexible diacylated piperazine linkers were designed, synthesized and evaluated as novel Bcr-Abl inhibitors.
Context: Leonurus artemisia (Lour.) S.Y.Hu (Lamiaceae) (YiMuCao in Chinese) is a traditional Chinese medicine. has been shown to have many pharmacological effects such as increasing uterine contraction amplitude, and tension, but the active components are still unknown.Objective: The objective of this study determine L. Artemisia that responsible for biological activity using HPLC cell membrane-based system.Materials methods: whole ethanol extract its eight fractions were screened...
The aim of the present study was to investigate protective effect eugenol on transplanted heart and explore its mechanisms action. Male Sprague‑Dawley rats were randomly divided into a sham group (n=10), (n=10 pairs, donors recipients) control recipients). recipients in received an intraperitoneal injection (20 mg/kg/day). equal volumes physiological saline by injection. After 15 days groups underwent abdominal heterotopic transplantation, while only coeliotomy. orthotopic hearts groups, as...
Abstract Tamsulosin hydrochloride is a commonly used drug for treatment of benign prostatic hyperplasia which disease affecting elderly men. However, adverse reactions may occur when tamsulosin long-term treatment. Caulis spatholobi traditional Chinese medicine with many pharmacological effects. In this study, cell membrane chromatography column was combined high-performance liquid chromatography–mass spectrometry to determine the active compounds acting on α1A adrenergic receptor from...
Herpes simplex virus 1 (HSV-1) is one of the most prevalent human pathogens in both industrialized and developing countries. This study was performed to analyze antiviral activity purified flavonoid from Polygonum perfoliatum L. against HSV-1 infection vitro vivo. Flavonoid showed no inhibitory effect, when treated before infection, but it strongly inhibited viral replication cell-to-cell spread which vital for virus's propagation. The therapeutic effect treating induced encephalitis also...
Liensinine, an important alkaloid in lotus seed, exhibits multiple functions such as anti-AIDS, anticancer, antidepressant, and antihypertensive properties. In this study, a highly sensitive HPLC-MS/MS method was developed validated for the quantification of liensinine microvolume rat plasma low 45 μL. Chromatographic separation carried out using reverse-phase Gemini-C18 column (100 mm × 3 i.d. 5 μm), mass selective detection reaction monitoring attained electrospray ionization source, which...
Most small-molecule drugs influence cell behavior through their interaction with one or more cellular proteins. The efficacy is unanticipated in the later stages of drug development if are discovered absence a biological context. Bionic screening an vivo drug-receptor platform that can identify small molecules recognized activity, improving likelihood clinic. Here, we report design innovative cell-based bionic system using 3D microcarrier cultures to simulate conditions and facilitate...
Highly functionalized xanthenes possess an impressive range of bioactivities and daunting synthetic challenge due to their unique ring systems stereocenters. Here, we report unprecedented ketyl radicals‐induced skeletal rearrangement reaction spirodihydrobenzofurans, enabled by zero‐valent iron as reducing agents via photoredox catalysis, facilitating the facile preparation various highly xanthenes. The features this protocol include high chemo‐ regioselectivity, exceptionally mild...