A5021486881- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Biological Activity of Diterpenoids and Biflavonoids
- Marine Sponges and Natural Products
- Crystallography and molecular interactions
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Microbial Natural Products and Biosynthesis
- Natural Compound Pharmacology Studies
- Carbohydrate Chemistry and Synthesis
- Phytochemistry and Biological Activities
- Synthesis of Indole Derivatives
- Radical Photochemical Reactions
- Alkaloids: synthesis and pharmacology
- Synthesis of Organic Compounds
- Axial and Atropisomeric Chirality Synthesis
- Bioactive Compounds and Antitumor Agents
- Antimicrobial Peptides and Activities
- Inorganic Chemistry and Materials
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
- Oxidative Organic Chemistry Reactions
- Catalytic C–H Functionalization Methods
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and characterization of novel inorganic/organometallic compounds
Jinan University
2017-2025
Jinan University
2025
Southern University of Science and Technology
2017-2020
A highly concise catalytic approach for the first asymmetric total syntheses of myrtucommuacetalones and callistrilones is reported.
Leptosperols A and B (1 2), two cinnamoylphloroglucinol–sesquiterpenoid hybrids featuring unprecedented 1-benzyl-2-(2-phenylethyl) cyclodecane 2-benzyl-3-phenylethyl decahydronaphthalene backbones, along with their biosynthetic precursor (3), were isolated from Leptospermum scoparium. Compounds 1 2 represent the first example of phloroglucinol derivatives biogenetically constructed by a De Mayo reaction. The biomimetic synthesis leptosperol (2) was achieved using proposed pathway. In...
The development of new antibiotics continues to pose challenges, particularly considering the growing threat multidrug-resistant Staphylococcus aureus. Structurally diverse natural products provide a promising source antibiotics. Herein, we outline concise approach for collective asymmetric total synthesis polycyclic xanthene myrtucommulone D and five related congeners. strategy involves rapid assembly challenging benzopyrano[2,3-a]xanthene core, highly diastereoselective establishment three...
Five monoterpenoid bisindole alkaloids with new carbon skeletons, gelsecorydines A–E (1–5), together their biogenetic precursors were isolated from the fruits of Gelsemium elegans. Compounds 1–5 represent first examples heterodimeric frameworks composed a gelsedine-type alkaloid and modified corynanthe-type one. Notably, compound 2 featured an unprecedented caged skeleton 6/5/7/6/5/6 heterohexacyclic ring system, which possessed pyridine that linked two monomers. Their structures absolute...
The first and asymmetric total synthesis of bioactive bufospirostenin A, an unusual spirostanol with rearranged A/B rings, was accomplished. synthetically challenging [5–7–6–5] tetracyclic ring system, found in A some other natural products, efficiently constructed by the unique intramolecular rhodium-catalyzed Pauson–Khand reaction alkoxyallene-yne. 11 stereocenters final product, including 10 contiguous stereocenters, were installed diastereoselectively.
Lagunamide D is a structurally distinct 26-membered cytotoxic cyclic depsipeptide, originally isolated from marine cyanobacterium. It exhibits potent antiproliferative activity in the low nanomolar range against A549 human lung adenocarcinoma cells and HCT116 colon cancer cells. A significant challenge associated with lagunamide its propensity for intramolecular acyl migration, which leads to formation of contracted 24-membered analog, D′. This structural rearrangement complicates isolation,...
Garcioblons A-F (1-6), six unprecedented polycyclic polyprenylated acylphloroglucinols (PPAPs) formed via intramolecular Diels-Alder (IMDA) reactions from monocyclic (MPAPs), were isolated Garcinia oblongifolia. Their structures elucidated through spectroscopic analysis and quantum calculations. Structurally, compound 1 is the first PPAP characterized by an 6/6/5/7/6/5/6/5 octacyclic ring system with a 11-oxatetracyclo[8.5.1.01,12.05,10]hexadecane motif, while 2-4 are its biogenetically...
Thrysaxinones A–F (1–6), six new phloroglucinol-terpenoid adducts (PTAs), were isolated from Thryptomene saxicola. Their structures and absolute configurations elucidated by extensive spectroscopic analysis, X-ray crystallography, quantum chemical calculations....
Three pairs of enantiomeric cinnamoyltriketone dimers, (+)‐ and (−)‐xanthochrysanthones A−C [(+)‐ (−)‐1–3)], were recognized obtained from Xanthostemon chrysanthus by employing the building blocks‐based molecular network (BBMN) strategy. Compounds 1–3 featured two new types lobster‐shape carbon skeletons with unprecedented spiro[cyclohexane‐1,2′‐xanthene] or benzo[7,8]oxocino[4,5‐b]chromene tetracyclic ring systems. Their structures absolute configurations established comprehensive...
A pair of enantiomeric triketone–phloroglucinol hybrids, (+)- and (−)-myrtuspirone (1), featuring an unprecedented 3-isopropyl-3H-spiro[benzofuran-2,1′-cyclohexane] backbone, were isolated from the leaves Myrtus communis. The absolute configuration each enantiomer 1 was determined by X-ray diffraction chemical calculations. Furthermore, gram-scale total syntheses (±)-1 (−)-1 conducted in four steps using a Michael-N-iodosuccinimide (NIS)-mediated (3 + 2)-annulation reaction. Both exhibited...
A highly concise approach for the first asymmetric and gram-scale total syntheses of callistrilones B, G J is reported.
Highly functionalized xanthenes possess an impressive range of bioactivities and daunting synthetic challenge due to their unique ring systems stereocenters. Here, we report unprecedented ketyl radicals‐induced skeletal rearrangement reaction spirodihydrobenzofurans, enabled by zero‐valent iron as reducing agents via photoredox catalysis, facilitating the facile preparation various highly xanthenes. The features this protocol include high chemo‐ regioselectivity, exceptionally mild...
Highly functionalized xanthenes possess an impressive range of bioactivities and daunting synthetic challenge due to their unique ring systems stereocenters. Here, we report unprecedented ketyl radicals‐induced skeletal rearrangement reaction spirodihydrobenzofurans, enabled by zero‐valent iron as reducing agents via photoredox catalysis, facilitating the facile preparation various highly xanthenes. The features this protocol include high chemo‐ regioselectivity, exceptionally mild...