A5101482298- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Nutritional Studies and Diet
- Craniofacial Disorders and Treatments
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Cleft Lip and Palate Research
- Advanced Radiotherapy Techniques
- Natural Compound Pharmacology Studies
- Tuberculosis Research and Epidemiology
- RNA modifications and cancer
- Obesity, Physical Activity, Diet
- Synthesis of Organic Compounds
- DNA Repair Mechanisms
- Radiation Detection and Scintillator Technologies
- Protein Structure and Dynamics
- Natural product bioactivities and synthesis
- Hemoglobin structure and function
- Access Control and Trust
- Bone Tumor Diagnosis and Treatments
- Glaucoma and retinal disorders
- PARP inhibition in cancer therapy
- Cardiovascular Health and Risk Factors
Regeneron (United States)
2024
Chang'an University
2024
Jinan University
2018-2023
Southeast University
2022
Shanghai East Hospital
2021-2022
Anshan Hospital
2022
Tongji University
2021
Shanghai Children's Medical Center
2021
Sixth Affiliated Hospital of Sun Yat-sen University
2018-2019
Sun Yat-sen University
2010-2019
BackgroundEpidemiological studies have suggested an association between external estimates of exposure to metals in air particles and altered heart rate variability (HRV). However, on the internal assessments HRV are limited.ObjectivesThe purpose this study was examine potential urinary among residents urban community Wuhan, China.MethodsWe performed a cross-sectional analysis 23 5-min indices (SDNN, standard deviation normal-to-normal intervals; r-MSSD, root mean square successive...
Studies suggest a potential link between low-grade metabolic acidosis and type 2 diabetes. A western dietary pattern increases daily acid load but the association diet-dependent diabetes is still unclear. This study aimed to assess whether associated with risk of We examined energy-adjusted net endogenous production (NEAP), renal (PRAL) animal protein-to-potassium ratio (A:P) on incident in 67,433 women from Nurses' Health Study, 84,310 Study II 35,743 men Professionals' Follow-up who were...
Background— Circulating microRNAs ( miRNAs) are emerging as novel disease biomarkers. We aimed to explore the association between circulating miRNAs and occurrence of acute myocardial infarction (AMI) in Chinese populations. Methods Results— In discovery stage, plasma 20 patients with AMI controls were pooled respectively profiled by massively parallel sequencing. Seventy-seven showed differential expression. Selected validated 178 198 using quantitative reverse transcriptase polymerase...
Background The prevalence of metabolic syndrome (MetS) is growing rapidly in China. Tai chi and dancing are common types exercise among middle-aged elderly Chinese. It remains unclear whether these activities associated with a lower risk MetS. Methodology/Principal Findings A total 15,514 individuals (6,952 men, 8,562 women) aged 50 to 70 years from the Dongfeng-Tongji Cohort Shiyan, China participated cross-sectional study. Physical activity other lifestyle factors were assessed...
Thrysaxinones A–F (1–6), six new phloroglucinol-terpenoid adducts (PTAs), were isolated from Thryptomene saxicola. Their structures and absolute configurations elucidated by extensive spectroscopic analysis, X-ray crystallography, quantum chemical calculations....
Although (GT) ( n ) repeats in heme oxygenase-1 (HO-1) promoter may modulate gene transcriptional activity, the association between polymorphism and risk of coronary heart disease (CHD) from different levels oxidative stress (OS) is unknown. We determined allelic frequencies HO-1 plasma malonaldehyde (MDA) as biomarkers OS 2,298 pairs CHD patients controls Chinese population. Furthermore, we measured MDA culture mediums expressions cell lysates endothelial cells carrying various genotypes...
1,2,3-Triazoles have come to the forefront as compounds of import in a vast number applications. The fundamental properties these species, however, remain largely unknown. Herein, gas phase 4-phenyl-1,2,3-triazole, benzotriazole, and series 1-phenylbenzotriazoles are described. Proton affinity acidity values computed measured. Furthermore, ion–molecule reactions H/D exchange studies used ascertain tautomer prevalence for 4-phenyl species.
Microgels (MGs) are crosslinked polymer particles that swell when the pH approaches pKa of constituent polymer. Our earlier work showed concentrated MG dispersions can be covalently interlinked to form macroscopic hydrogels, which termed doubly microgels (DX MGs). Here, we study for first time effects intra-MG crosslinking on swelling MGs and mechanical properties DX MGs. The were synthesised by emulsion copolymerisation ethyl acrylate (EA) or methacrylic acid (MAA) divinylbenzene (DVB)....
Background DNA damage response (DDR) proficiency is the principal mechanism of temozolomide (TMZ) resistance in glioma. Accumulating evidence has also suggested determining role DDR anticancer immunity. We propose that a comprehensive investigation landscape can optimize glioma treatment. Methods identified pronounced enrichment TMZ-resistant cells by RNA sequencing. Nine differentially expressed genes between TMZ-sensitive/resistant were selected to construct score through lasso regression...
A two-layer model which includes a channelized Hotelling observer (CHO) followed by (HO) is proposed to operate on three-dimensional images containing multiple slices and views similar clinical displays of SPECT myocardial perfusion images. The was applied simulated data an idealized heart model. task the detection cold defects in wall. CHO computed for each slice multislice image HO then decision variable arrays obtain CHO-HO lesion detectability index. Results are compared those...
Abstract BACKGROUND : All‐trans‐retinoic acid (ATRA), a known teratogenic factor affecting the development of cleft palate, has been shown to adversely affect craniofacial development. In present study, we evaluated effects ATRA on osteo‐/adipogenic differentiation mouse embryonic palate mesenchymal (MEPM) cells, which served as valid model system for investigating mechanisms regulating osteogenesis during palatogenesis. METHODS MEPM cells were derived from gestational day 13 C57BL/6N...
Callistrilones F - K (1 6), six new triketone-phloroglucinol-monoterpene hybrids were isolated from the twigs and leaves of Callistemon rigidus. Their structures with absolute configurations established by a combination analysis NMR spectra, X-ray diffraction, electronic circular dichroism (ECD) calculations. Compounds 3 4 exhibited moderate inhibitory activities against herpes simplex virus (HSV-1) IC50 values 10.00 ± 2.50 12.50 1.30 μm, respectively.
The forearm deformity classified by Masada is a characteristic trait of patients with hereditary multiple exostoses (HME). Ulnar gradual lengthening, which was considered to be safe and reliable procedure, popular in treating these difficult deformities, however, delayed consolidation the callus uncommon but not rare literature review. purpose this study try identify risk factors influencing bone healing ulnar lengthening HME.We retrospectively reviewed HME-induced who underwent at our...
To characterize the prenatal and postnatal craniofacial bone development in mouse model of all-trans retinoic acid (ATRA) exposure at different ages by a quantitative morphological analysis skull morphology.Pregnant mice were exposed to ATRA embryonic day 10 (E10) 13 (E13) oral gavage. Skulls embryos E19.5 adult 35 (P35) collected for high-resolution microcomputed tomography (microCT) imaging scanning section HE staining. Reconstruction measurement skulls performed control ATRA-exposed...
Abstract The first isolable, photoswitchable N‐heterocyclic carbene was synthesized and found to undergo reversible electrocyclic isomerization upon successive exposure UV visible radiation. UV‐induced ring closure afforded substantial changes the electronic structure of dithienylethene‐based NHC, as evidenced by in corresponding UV/Vis absorption 13 C NMR spectra. Likewise, molecular orbital calculations revealed diminished electron density at nucleus photocyclization, consistent with...