A5054659240- Bone Tumor Diagnosis and Treatments
- Elbow and Forearm Trauma Treatment
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Oral and Maxillofacial Pathology
- Ocular Infections and Treatments
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Ocular Surface and Contact Lens
- Sarcoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Congenital limb and hand anomalies
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Resilience and Mental Health
- Problem Solving Skills Development
- Cancer Genomics and Diagnostics
- Medical and Biological Ozone Research
- Gut microbiota and health
- Neurogenetic and Muscular Disorders Research
- Shoulder Injury and Treatment
- Cancer-related Molecular Pathways
Guangdong Medical College
2017-2025
China Pharmaceutical University
2024
Shanghai Children's Medical Center
2011-2023
Shanghai Jiao Tong University
2020-2023
University of Göttingen
2021-2023
Universitätsmedizin Göttingen
2021-2023
First Hospital of Shijiazhuang
2023
I-Shou University
2019-2022
Weatherford College
2022
Hebei University of Chinese Medicine
2019
Abstract Objective Infection with Helicobacter pylori ( H ), especially cytotoxin‐associated gene A‐positive (CagA+) strains, has been associated various gastrointestinal and extragastric diseases. The aim of this study was to characterize ‐induced alterations in the gastric tongue coating microbiota evaluate their potential impacts on human health. Design mucosa specimens were collected from 80 patients chronic gastritis, profiles generated by 16S rRNA sequencing. Samples grouped as...
Nitrate electroreduction to ammonia has broad prospects as a complementary route the energy-intensive Haber-Bosch industry. Currently, most electrocatalytic NO3−-to-NH3 transformations are achieved in alkaline electrolyte, which not only requires...
Objective Pneumothorax (PTX) can be diagnosed using lung ultrasonography (LUS) in adult patients, but there are only a few reports of LUS PTX diagnosis neonates. The aim the study was to assess diagnostic accuracy for PTX. Study Design This retrospective review performed our neonatal intensive care unit (level III) between June 2015 and 2018. All eligible patients underwent an scan before undergoing chest X-ray (CXR), which considered reference standard. When inconsistent CXR, computed...
To characterize the serum metabolism in patients with Helicobacter pylori-positive and H. pylori-negative gastritis.Clinical data gastric function parameters, PGI (pepsinogen I), PGII, PGR (PGI/II), G-17 (gastrin-17) of 117 chronic gastritis were collected, including 57 pylori positive 60 negative subjects. Twenty cases each group randomly selected to collect intestinal mucosa specimens samples. The gut microbiota profiles generated by 16S rRNA gene sequencing, metabolites analyzed a...
ABSTRACT Growth and differentiation factors (GDFs) are secreted signaling molecules within the BMP family that have critical roles in joint morphogenesis during skeletal development mice humans. Using genetic data obtained from a six-generation Chinese family, we identified missense variant GDF6 (NP_001001557.1; p.Y444N) fully segregates with novel autosomal dominant synostoses (SYNS) phenotype, which designate as SYNS4. Affected individuals display bilateral wrist ankle deformities at birth...
Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers. Given currently limited therapeutic options, definition molecular subgroups with development tailored therapies promising strategy. Patients high-level gene amplification urokinase plasminogen activator receptor (uPAR/PLAUR) have an inferior prognosis. We analyzed uPAR function in PDAC to understand this understudied subgroup’s biology better. Methods: A total 67 samples clinical follow-up and TCGA...
The treatment of non-small cell lung cancer (NSCLC), particularly adenocarcinoma (LUAD), represents a significant oncological challenge due to its aggressive behavior, high metastatic potential and poor prognosis. HER2 mutation is rare but critical oncogenic driver associated with resistance traditional therapies among NSCLC subtypes, including chemotherapy tyrosine kinase inhibitors (TKIs). Trastuzumab deruxtecan (T-DXd), next-generation antibody-drug conjugate, combines HER2-targeted...
We conducted a comprehensive study to investigate the role of genes involved in transport pathways response chemotherapy and clinical outcome osteosarcoma cases. Genotyping six SNPs was performed 384-well plate format on Sequenom MassARRAY platform for 208 patients reveal any correlations with outcome. Individuals ABCB1 rs1128503 TT ABCC3 rs4148416 genotypes had higher probability responding poorly chemotherapy, indicated by odds ratios (ORs) 2.46 (95%CI, 1.21-5.74) 3.78 (95% CI,...
Abstract Hepatocellular carcinoma (HCC) is a highly invasive malignancy. Recently, GATOR1 (Gap Activity TOward Rags 1) complexes have been shown to play an important role in regulating tumor growth. NPRL2 critical component of the complex. Therefore, this study used knockdown investigate how GATORC1 regulates prognosis and development HCC via mammalian target rapamycin (mTOR) autophagy signaling pathways. We established HepG2 cells with using small interfering RNA (siRNA) short hairpin...
Abstract Background Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is an infrequent type of primary liver cancer that comprises (HCC) (CC). This study investigated the clinicopathological features prognosis among cHCC-CC, HCC, CC groups. Methods We prospectively collected data 608 patients who underwent surgical resection for between 2011 2018 at E-Da Hospital, I-Shou University, Kaohsiung, Taiwan. Overall, 505 with were included, their features, overall survival (OS),...
Hereditary multiple exostoses (HME) is a rare autosomal dominant skeletal disorder that can cause variety of clinical manifestations. We aimed to evaluate the general phenotypic severity HME by using scoring system and correlate genotypes with different phenotypes in Chinese patients. Forty-six patients from families were prospectively enrolled. The mutations identified direct sequencing PCR-amplified genomic DNA or multiplex ligation-dependent probe amplification (MLPA). Patients'...
Abstract Hereditary multiple osteochondroma (HMO) is one of the most common genetic skeletal disorders. It caused by mutations in either EXT1 or EXT2 resulting abnormal growth and morphogenesis. However, spectrum frequency Chinese patients with HMO was not previously investigated. Mutations were identified performing Sanger sequencing analysis complete coding regions flanking intronic sequences , followed multiplex ligation-dependent probe amplification (MLPA) to detect gene deletions...
To compare the bacterial flora in palpebral conjunctiva of xerophthalmia seniors Tibetan, Yi and Han, analyze differences similarities bacteria.The test subjects were selected from 2 3 Han populated places, respectively. Total 222 (444 eyes) with dry eye examined. Secretion was collected then inoculated onto a blood agar plate. After 48h incubation, bacteria examined for between different ethnics.There no significant difference (P>0.05) Gram stain characterization, dominant number species...
The forearm deformity classified by Masada is a characteristic trait of patients with hereditary multiple exostoses (HME). Ulnar gradual lengthening, which was considered to be safe and reliable procedure, popular in treating these difficult deformities, however, delayed consolidation the callus uncommon but not rare literature review. purpose this study try identify risk factors influencing bone healing ulnar lengthening HME.We retrospectively reviewed HME-induced who underwent at our...
Open reduction combined with ulnar osteotomy is the most common approach to treating missed Monteggia injuries. The usually performed at proximal ulna ensure better healing and fewer complications. purpose of this study present a center rotation angulation (CORA)-based for Bado type I We retrospectively reviewed cases patients who were treated open CORA-based between February 2014 December 2016. Each patient provided his or her internal control, paired data involved uninvolved sides analyzed...
Abstract Background The benefits of surgical resection (SR) for various Barcelona Clinic Liver Cancer (BCLC) stages hepatocellular carcinoma (HCC) remain unclear. We investigated the risk factors overall survival (OS) and SR over nonsurgical treatments in patients with HCC BCLC stages. Methods Overall, 2316 were included, their clinicopathological data OS recorded. was analyzed by Kaplan-Meier method Cox regression analysis. Propensity score matching (PSM) analysis performed. Results In...
Activating KRAS mutations occur in about 30% of pulmonary adenocarcinoma (AC) cases and the discovery specific inhibitors G12C-mutated has considerably improved prognosis for a subgroup 14% non-small cell lung cancer (NSCLC) patients. However, even patients with G12C mutation, overall response rate only reaches 40% other than still cannot be targeted. Despite fact that one-carbon metabolism (1CM) epigenetic regulation are known to dysregulated by aberrant activity, we lack evidence...
Abstract Background Gradual ulnar lengthening is the most commonly used procedure in treatment of Masada type I/II deformity patients with hereditary multiple osteochondromas. However, remains controversial for recurrence growing children. This study aims to evaluate clinical and radiological outcomes gradual our clinic. Methods We retrospectively reviewed who underwent by distraction osteogenesis from June 2008 October 2017. The carrying angle (CA) range motion (ROM) forearm elbow were...
To compare the status of bacteria in conjunctival sac from elder Qiang minority and Han people with dry eyes Sichuan, China.
The efficacy of sorafenib in combination with transarterial chemoembolization (TACE) or multiple-line therapies patients advanced hepatocellular carcinoma (HCC) remains unclear. This study aimed to investigate the overall survival (OS) HCC response different therapies.We analyzed treatment and OS 401 Barcelona clinic liver cancer stage C between 2012 2017. Mortality was using multivariate Cox regression, by Kaplan-Meier method.The mean age 59 years males were predominant. During a median...