A5077902632- Aquatic Ecosystems and Phytoplankton Dynamics
- Soil and Water Nutrient Dynamics
- Marine and coastal ecosystems
- Multiple Myeloma Research and Treatments
- Protein purification and stability
- CAR-T cell therapy research
- FOXO transcription factor regulation
- Diverticular Disease and Complications
- Water Quality and Pollution Assessment
- Monoclonal and Polyclonal Antibodies Research
- Diatoms and Algae Research
- Hydrology and Watershed Management Studies
- Polyamine Metabolism and Applications
- Pharmacological Effects of Natural Compounds
- Protein Degradation and Inhibitors
- Biocrusts and Microbial Ecology
- Biosimilars and Bioanalytical Methods
- Photonic and Optical Devices
- Advanced Proteomics Techniques and Applications
- Gastrointestinal disorders and treatments
- Photonic Crystals and Applications
- Pharmacogenetics and Drug Metabolism
- Environmental Quality and Pollution
- Food Quality and Safety Studies
- Reproductive biology and impacts on aquatic species
Janssen (United States)
2016-2025
Tianjin Medical University Cancer Institute and Hospital
2019-2025
Wuhan Academy of Agricultural Sciences
2023-2025
Chinese Academy of Sciences
2008-2024
Second Hospital of Tianjin Medical University
2024
University of Chinese Academy of Sciences
2008-2024
Nanjing Institute of Geography and Limnology
2020-2024
Tianjin Medical University
2024
Qingdao University
2024
Sichuan Agricultural University
2023
8003 Background: Tal is a T-cell redirecting bispecific antibody (BsAb) targeting G protein–coupled receptor family C group 5 member D. Dara an anti-CD38 mAb with direct on-tumor and immunomodulatory actions. Combining effects of tal + dara may lead to synergistic efficacy. Initial TRIMM-2 (NCT04108195) results showed that SC RP2Ds, 0.4 mg/kg QW or 0.8 Q2W, had promising efficacy increased CD38+/CD8+ T cells proinflammatory cytokines. We report updated additional pts longer follow-up....
The commonly used LC-MS workflow to quantify protein therapeutics in biological samples is 'bottom-up' approach. In this study, the aim establish 'top-down' approach for absolute quantitation of therapeutic antibodies or proteins similar sizes at intact level.Using a recombinant human monoclonal antibody as model molecule, we present measure large plasma level based on deconvoluted high-resolution MS (HRMS) peaks. A novel MultiQuant™ software function was developed automatically deconvolute...
Introduction The purpose of this research was to investigate how dietary supplementation with fermented herbal residues (FCMR) affected birds' development capacity, quality meat, gut barrier, and cecum microbiota. Methods 540 cyan-shank partridge birds aged 47 days were chosen divided into two groups six replicates each 45 for replicate. control group (CON) received a basal diet, while the trial decreased basic diet containing 5% FCMR. Results discussion findings revealed that addition FCMR...
Abstract Bone metastases occur in most advanced breast cancer patients and cause serious skeletal-related complications. The mechanisms by which bone metastasis seeds develop primary tumors specifically colonize the remain to be elucidated. Here, we show that forkhead box F2 (FOXF2) functions as a master transcription factor for reprogramming cells into an osteomimetic phenotype pleiotropic transactivation of BMP4/SMAD1 signaling pathway bone-related genes are expressed at early stages...
As therapeutic recombinant fusion proteins become more widely applicable for the treatment of various types diseases, there is an increased demand universal methods such as liquid chromatography (LC)-mass spectrometry (MS) determination their pharmacokinetic properties, particularly catabolism. The most common approach analyzing by LC-MS to digest them into peptides, which can serve surrogates protein. Alternatively, we have developed a novel high-resolution mass (HRMS) based large-molecule...
FOXF2 and FOXQ1, forkhead box transcription factor superfamily members, are encoded by neighboring genes located on human chromosome 6p25.3 play opposite roles in epithelial-mesenchymal transition (EMT) metastasis basal-like breast cancer (BLBC). However, the relationship between FOXQ1 remains unknown. Here, we found mutual transcriptional repression reciprocal negative feedback loop controlled EMT, aggressiveness, chemoresistance BLBC cells. We further demonstrated that recruited nuclear...
Metabolic labeling with heavy water (D2O) followed by LC-MS has become a powerful tool for studying protein turnover in vivo. Developing quantitative method to measure partially labeled low-abundance proteins poses many challenges because isotopomers of peptides, especially their changes through deuterium labeling, are difficult detect. A workflow that coupled immunocapture and LC-high-resolution MS determine the synthesis rate HSD17β13 mouse liver was presented. Deuterium tryptic peptides...
This study aimed to investigate the effects of fermented Astragalus polysaccharides(FAP) on growth performance, antioxidant capacity and intestinal health broilers. A total 1,080 Cyan-shank Partridge chickens were divided into 4 groups, with 6 replicates per group 45 replicate. Add 0% (T1), 0.2% (T5), 0.4% (T6) 0.6% (T7) FAP basal diet, respectively. The trial lasted for 42 days. results indicated that, compared T1 group, FW ADG broilers in each treatment significantly increased (p < 0.05)....
Estrogen receptor-positive (ER+) breast cancer accounts for 80% cases. The estrogen-ERα signaling pathway plays a pivotal role in driving the progression of ER+ cells. Thus, endocrine therapy targeting is predominant treatment cancer. Most patients with require long-term agents. Although effectively improves survival cancer, bone metastasis frequently occurs receiving due to acquired resistance. Elucidating molecular mechanisms underlying endocrine-resistance and developing effective...
Aim: Sample extraction using immuno-affinity capture coupled with LC–high-resolution mass spectrometer has recently emerged as a novel approach for the determination of concentrations large molecules at intact level in biological matrix. Methodology: In current work, different data processing strategies protein bioanalysis, deconvoluted spectra or extracted ion chromatogram, were applied to quantitate monoclonal antibody samples comparison assay performance. Conclusion: Both deconvolution...
This research aimed to assess the impact of fermented Citri Sarcodactylis Fructus by-products (FCSF) on growth performance, gut digestive enzyme activity, nutrient utilization efficiency, microbiota, and their metabolites in broiler chickens. A total 1,080 male chickens were allocated into four groups (T1-T4) consisting 6 replicates per group, each containing 45 The basal diet was provided group T1, while T2, T3, T4 supplemented with 1%, 3%, 5% FCSF diet, respectively. experimental period 42...