A5051461894- Chronic Lymphocytic Leukemia Research
- Aquatic Ecosystems and Phytoplankton Dynamics
- Vehicle emissions and performance
- MicroRNA in disease regulation
- Traffic and Road Safety
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer, Hypoxia, and Metabolism
- Marine and coastal ecosystems
- Trace Elements in Health
- Eosinophilic Disorders and Syndromes
- Energy, Environment, and Transportation Policies
- Histiocytic Disorders and Treatments
- Tryptophan and brain disorders
- Advanced Combustion Engine Technologies
- Multiple Myeloma Research and Treatments
- Circular RNAs in diseases
- Lymphoma Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Microbial Community Ecology and Physiology
- Quinazolinone synthesis and applications
- Renal Diseases and Glomerulopathies
- Chronic Myeloid Leukemia Treatments
- Cytokine Signaling Pathways and Interactions
- Autophagy in Disease and Therapy
- Blood disorders and treatments
Xiamen University
2011-2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Nanjing Institute of Geography and Limnology
2024-2025
Chinese Academy of Sciences
2024-2025
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
Gannan Normal University
2025
China National Health Development Research Center
2025
Institute of Economics
2025
Sichuan University
2021-2024
SUMMARY Zinc (Zn) is an essential micronutrient for most organisms including humans, and Zn deficiency widespread in human populations, particularly underdeveloped regions. Cereals such as rice ( Oryza sativa ) are the major dietary source of people. However, molecular mechanism underlying uptake still not fully understood. Here, we report that a member ZIP (ZRT, IRT‐like protein) family, OsZIP9, contributes to rice. It was expressed epidermal exodermal cells lateral roots, localized plasma...
The monitoring and management of aquatic ecosystems depend on precise estimates biodiversity. Metabarcoding analyses environmental nucleic acids (eNAs), including DNA (eDNA) RNA (eRNA), have garnered attention for their cost-effective non-invasive biomonitoring capabilities. However, the accuracy biodiversity obtained through eNAs can vary among different organismal groups. Here we evaluate performance eDNA eRNA metabarcoding across nine groups, ranging from bacteria to terrestrial...
Fibrosarcoma is an aggressive and highly metastatic cancer of the connective tissue, for which effective therapeutic methods are limited. Recently, there has been a renewed interest in small molecular compounds from natural products treatment cancer. In present study, we investigated compound, scutellarein, extracted perennial herb Scutellaria lateriflora, it was found to possess anticancer potential. Cell proliferation assay cell cycle analysis revealed that rate HT1080 human fibrosarcoma...
Cervical cancer (CC) remains a highly prevalent and mortality globally among women globally. The aim of the present study was to assess ability miR‐374b regulate CC cells through JAM‐2, whilst exploring whether underlying mechanism its relation p38/ERK signaling pathway. During study, microRNA‐374b (miR‐374b) observed have been expressed at low level tissues. Hence, series mimics, inhibitors, siRNA against SB202190 (an inhibitor for p38), PD98059 ERK) were introduced treat Siha normal...
Matrix metalloproteinases (MMPs) play an active role in facilitating the invasion of cancer cells with excessive extracellular matrix (ECM) degradation. In present study, we investigated antiinvasive effects isorhamnetin, a naturally occurring flavonoid, on MDA-MB-231 human breast carcinoma cells. The results indicated that isorhamnetin significantly inhibited adhesion, migration, and vitro. Moreover, suppressed activity expression MMP-2 MMP-9, which were determined by gelatin zymography,...
Abstract Introduction Septic cardiomyopathy is a common complication of sepsis with high morbidity and mortality, but lacks specific therapy. This study aimed to reveal the role circTLK1 its potential mechanisms in septic cardiomyopathy. Materials Methods The vitro vivo models were established. Cell viability apoptosis detected by CCK8, TUNEL flow cytometry, respectively. LDH, CK, SOD, MDA, ATP, 8‐OHdG, NAD+/NADH ratio, ROS level, mitochondrial membrane cytochrome C distribution evaluated...
The aim of this paper was to study the antitumor and immunoregulatory activities a polysaccharide (TTP) from Talinum triangulare. molecular weight TTP-IV 49.9 kDa. monosaccharide composition analysis revealed that it heteropolysaccharide consisting rhamnose, arabinose, mannose galactose with molar ratio 1.22 : 1.00 1.05 1.51. results in vivo showed TTP (200 mg per kg bw) significantly inhibited growth tumor by 49.07% H22-bearing Kunming mice. In vitro, primary murine macrophages promoted...
Radiotherapy is the primary treatment for nasopharyngeal carcinoma (NPC). Patients with intermediate and advanced stage NPC receiving only radiotherapy have limited survival, so newer immunotherapeutic approaches are sought. The major impediment to better clinical outcomes tumor immune tolerance. Indoleamine 2,3-dioxygenase (IDO), an IFNγ-inducible enzyme, a inducer of tolerance during development; therefore, inhibition IDO pathway important modality cancer treatment. We show that...
Hepatocellular carcinoma (HCC) remains the third cause of cancer-related mortality. Resection and transplantation are only curative treatments available but greatly hampered by high recurrence rates development metastasis, initiation cancer metastasis requires migration invasion cells, which is enabled epithelial-mesenchymal transitions (EMT). TGF-β1 a secreted protein that performs many cellular functions, including control cell growth, proliferation, differentiation apoptosis. known as...
Abstract Background Severe ulcerative colitis (UC) is associated with increasing risk of admission and colectomy. Till now, there are limited number studies on the predictive models for severe UC especially in Asian population. In this study, we aimed to develop validate a model Chinese patients using machine learning algorithm. Methods Patients diagnosed mild-to-moderate were included retrospectively at four tertiary hospitals China from 2013 2016. The primary outcome was requring...
We study the cluster complex $\mathrm{Cpx}(\mathcal{C})$ of a 2-Calabi-Yau category $\mathrm{Cpx}(\mathcal{C})$. For any point $\mathrm{X}$ in $\mathrm{Cpx}(\mathcal{C})$, we introduce an $\mathrm{X}$-evolution flow on show that such induces piecewise linear one-dimensional $\mathrm{X}$-foliations with two singularities, unique sink and source $\mathrm{X}[1]$. In case when $\mathcal{C}$ is Dynkin or Euclidean quiver $Q$, prove $\mathrm{X}$-foliation either compact semi-compact, for various...
Amid the global wave of digital economy, China's medical artificial intelligence applications are rapidly advancing through technological innovation and policy support, while facing multifaceted evaluation regulatory challenges. The dynamic algorithm evolution undermines assessment criteria consistency, multimodal systems lack unified metrics, conflicts persist between data sharing privacy protection. To address these issues, China National Health Development Research Center has established...
Deubiquitinase OTUB2 plays a critical role in the progression of various tumors. However, its specific triple-negative breast cancer (TNBC) remains unclear. This study aims to elucidate biological function TNBC and uncover underlying mechanisms. First, we found that expression was upregulated by bioinformatics analysis, then validated tissues cells using immunohistochemistry (IHC) qPCR plotted survival curves Kaplan-Meier method. Gene set enrichment analysis (GSEA) suggested may be involved...
Qiandao Lake is an important source of drinking water in the Yangtze River Delta, and its ecological environment great strategic significance to surrounding areas. To identify sources spatial distribution characteristics nitrate （NO3--N） pollution Lake, we conducted, for first time, collection samples from four typical mountainous inlet river basins Basin, analyzed concentrations NO3--N, resolved different their contribution each system by combining δ15N-NO3- δ18O-NO3- dual stable isotope...
The weldability of DP780 steel using resistance spot welding (RSW) was studied by comparing a new ring conductive electrode (RSW-R) and spherical (RSW-S). mechanism the RSW process annular-nugget on analyzed examining joint’s current density thermal field. Finite element analysis revealed that under RSW-R conditions, annular area expanded contact faying surface reduced nugget’s density. This characteristic effectively mitigated risk expulsion associated with high heat input rates excessively...
In recent years, the integration of electroencephalogram (EEG) and somatosensory data in athlete potential evaluation has garnered increasing attention. Traditional research methods mainly rely on processing EEG signals or motion sensor independently. While these can provide a certain level performance assessment, they often overlook synergy between brain activity physical movement, making it difficult to comprehensively capture an athlete's potential. Moreover, most existing approaches...
The digital economy serves as a vital engine for addressing the employment challenges posed by an aging population. By enhancing skills of older individuals and creating more flexible opportunities, it can significantly alleviate labor supply pressures pave way high-quality economic growth. This study analyzes panel data from various provinces in China between 2012 2022, employing both fixed-effect threshold models to examine influence on scale context demographic aging. findings indicate...
Penile squamous cell carcinoma (PSCC) is a highly aggressive malignancy without effective treatment due to limited knowledge of its development and tumor microenvironment (TME). In this study, single-nucleus RNA sequencing (snRNA-seq) high-resolution spatial transcriptomics are employed comprehensively investigate the trajectories TME. The results revealed that PSCC cells mimicked differentiation tissue organization normal penile epithelium, independent human papillomavirus (HPV) infection...