A5100683403- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- Microstructure and Mechanical Properties of Steels
- Phytochemical compounds biological activities
- Traditional Chinese Medicine Analysis
- Gut microbiota and health
- Phytochemistry and Bioactive Compounds
- Cancer-related molecular mechanisms research
- Seaweed-derived Bioactive Compounds
- IL-33, ST2, and ILC Pathways
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Pharmacological Effects of Natural Compounds
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Cardiac electrophysiology and arrhythmias
- Essential Oils and Antimicrobial Activity
- Microbial Metabolites in Food Biotechnology
- Aluminum Alloy Microstructure Properties
- Food Quality and Safety Studies
- Bioactive natural compounds
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- vaccines and immunoinformatics approaches
Yancheng Institute of Technology
2025
First Affiliated Hospital of Harbin Medical University
2014-2024
Harbin Medical University
2014-2024
Northeastern University
2024
Universidad del Noreste
2023
Shenyang Pharmaceutical University
2009-2022
ORCID
2021
Fu Wai Hospital
2021
Changchun University of Chinese Medicine
2015-2020
Guiyang Medical University
2019
Abstract Aims Ageing is the most significant contributor to increasing prevalence of atrial fibrillation (AF). The gut microbiota dysbiosis involved in age-related diseases. However, whether aged-associated contributes AF still unknown. Direct demonstration that aged sufficient transmit enhanced susceptibility a young host via microbiota-intestinal barrier-atria axis has not yet been reported. This study aimed determine affects AF. Methods and results Herein, by using faecal transplantation...
Cold exposure is one of the most important risk factors for atrial fibrillation (AF), and closely related to poor prognosis AF patients. However, mechanisms underlying cold-related are poorly understood.Various techniques including 16S rRNA gene sequencing, fecal microbiota transplantation, electrophysiological examination were used determine whether gut dysbiosis promotes AF. Metabonomics performed investigate changes in trimethylamine (TMA) plasma N-oxide (TMAO) during cold exposure. The...
High-Co–Ni secondary hardening steels are valuable in the field of aviation materials. With increasing demand lightweight, further enhancing its strength has received widespread attention. In this study, instead using only M2C carbides as reinforcements traditional high Co–Ni steels, nano-size NiAl phases were introduced to provide additional strength. To obtain collaborative precipitation these two reinforcements, systematically thermodynamic calculation, including driving force, coarsening...
There are accumulating reports that microRNAs dysregulated in a number of human cancer types, and they may function as tumor suppressors or oncogenes tumorigenesis development. microRNA-215 (miR-215) has been identified suppressor epithelial ovarian, pancreatic, non-small cell lung colon cancer, whereas it act an oncogene gastric cervical cancer. The role miR-215 breast carcinogenesis progression yet to be elucidated. In the present study, expression level was determined tissues lines using...
The aim of this paper was to study the antitumor and immunoregulatory activities a polysaccharide (TTP) from Talinum triangulare. molecular weight TTP-IV 49.9 kDa. monosaccharide composition analysis revealed that it heteropolysaccharide consisting rhamnose, arabinose, mannose galactose with molar ratio 1.22 : 1.00 1.05 1.51. results in vivo showed TTP (200 mg per kg bw) significantly inhibited growth tumor by 49.07% H22-bearing Kunming mice. In vitro, primary murine macrophages promoted...
Colorectal cancer (CRC) ranks second in cancer-associated mortality and third the incidence worldwide. Most of CRC follow adenoma-carcinoma sequence, have more than 90% chance survival if diagnosed at early stage. But recommended screening by colonoscopy is invasive, expensive, poorly adhered to. Recently, several studies reported that fecal bacteria might provide non-invasive biomarkers for precancerous tumors. Therefore, we collected uniformly re-analyzed these published 16S rDNA...
Emerging evidence indicates that long non-coding RNAs (lncRNAs) serve as a critical molecular regulator in various cardiovascular diseases. Here, we aimed to identify and functionally characterize lncRNAs potential mediators the development of thoracic aortic dissection (TAD). We identified novel lncRNA, lnc-C2orf63-4-1, was lowly expressed samples TAD patients angiotensin II (Ang II)-challenged vascular smooth muscle cells (VSMCs), which correlated with clinically expansion. Besides,...
Zbtb7A is a proto-oncogenic transcriptional regulator that plays an important role in adipogenesis, osteogenesis and oncogenesis, but little known about the regulation of gene expression which importance function uncovering this gene.Here, 5'-flanking region human was cloned characterized. It found GC box within promoter necessary for activity. Furthermore, we identified Sp1 acts as activator activity physical interaction between responsible activation promoter.Our results confirmed...
The present study evaluated the immune function of extract obtained from yellow pond turtle (YPT). Two YPT doses (250 mg/kg and 500 mg/kg·bw/d) were administered orally to normal cyclophosphamide (CY)-induced immune-suppressed male Kunming mice, respectively. by testing body weight growth curve, thymus index spleen in CY-induced mice as well mononuclear-macrophage phagocytic carbonic particle clearances macrophage phagocytose index. After a 10-day administration, both low-dose group...
Two new secoiridoid glycosides, verbenoside A (1) and B (2), have been isolated from the ethanol extract of aerial parts Verbena officinalis L. Their structures were elucidated on basis spectroscopic evidences, especially 1D, 2D NMR, MS experiments.
Two new triterpenoid saponins, namely ginsenoside Re8 (1) and notoginsenoside ST-8 (2), were isolated from ginseng medicinal fungal substance. Their structures elucidated by spectroscopic data chemical analysis.
Two new dammarane-type triterpenoid saponins, namely ginsenosides Rb4 (1) and Rb5 (2), were isolated from ginseng medicinal fungal substance. The structures of 1 2 established as 3β,12β,20(S)-trihydroxydammar-24(25)-ene-3-O-[α-d-glucopyranosyl-(1→4)-β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl]-20-O-β-d-glucopyranoside 3β,12β,20(S)-trihydroxydammar-24(25)-ene-3-O-[α-d-glucopyranosyl-(1→4)-α-d-glucopyranosyl-(1→4)-β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl]-20-O-β-d-glucopyranoside on the...
The objective of this study was to investigate the effect ATP7B antisense oligodeoxynucleotides (ASODNs) on regulating sensitivity cisplatin in ovarian carcinoma cell line SKOV3ip1. ASODNs and corresponding sense oligodeoxynucleotide (SODN) as control were transfected into SKOV3ip1 cells by lipofectamine-2000. changes detected reverse transcription-polymerase chain reaction, flow cytometry, Western blotting. survival rate assessed MTT assay. Compared with nontransfected cell, transfer...
Three new triterpenoid saponins, named ginsenoside‐Rh 23 ( 1 ), 24 2 and 25 3 were isolated from notoginseng medicinal fungal substance. Their structures elucidated by a combination of 1D‐ 2D‐NMR, MS chemical analysis. Compounds – exhibited moderate cytotoxic activity against MCF‐7 NCI‐H460 cancer cell lines.
<title>Abstract</title> Background: Evidence regarding the health effects of saturated fatty acids (SFAs), monounsaturated (MUFAs), and total polyunsaturated (PUFAs) is controversial. Our objective was to explore associations between serum-free mortality among cancer survivors. Methods: The study included 6,575 participants with or without diagnosis aged 20 years older a who were recruited before December 2014 followed up through 31, 2019. Hazard ratios (HRs) 95% confidence intervals (CIs)...
Abstract Background: Aging is the most significant contributor to increasing prevalence of atrial fibrillation (AF). The gut microbiota dysbiosis involved in age-associated diseases. However, whether microbial contributes AF still unknown. aim this study was evaluate effect on susceptibility aging-induced and elucidate underlying mechanisms. Results: profiling fecal samples aged (22-24 months old) young (2-3 rats performed by 16S ribosomal RNA gene analysis. A rat model transplantation (FMT)...