A5100688296- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Phytochemical compounds biological activities
- Cholinesterase and Neurodegenerative Diseases
- Phytochemicals and Antioxidant Activities
- Sesquiterpenes and Asteraceae Studies
- Fungal Biology and Applications
- Marine Sponges and Natural Products
- Coleoptera Taxonomy and Distribution
- Forest Ecology and Biodiversity Studies
- Essential Oils and Antimicrobial Activity
- Bioactive Natural Diterpenoids Research
- Plant biochemistry and biosynthesis
- Scarabaeidae Beetle Taxonomy and Biogeography
- Chemical synthesis and alkaloids
- Natural Compounds in Disease Treatment
- Phytochemical Studies and Bioactivities
- Fossil Insects in Amber
- Phytochemistry and Bioactivity Studies
- Piperaceae Chemical and Biological Studies
- Natural Antidiabetic Agents Studies
- Potato Plant Research
- Medicinal plant effects and applications
- Pharmacological Effects of Natural Compounds
Shenyang Pharmaceutical University
2016-2025
Beihang University
2022-2024
Ningxia University
2022-2024
Institute of Zoology
2016-2023
Chinese Academy of Sciences
2016-2023
Xi'an Jiaotong University
2023
University of Chinese Academy of Sciences
2021-2022
Jiangsu Second Normal University
2022
Guangzhou Maritime College
2021
Guangxi University
2021
Abstract By manipulating their asymmetric electronic spin states, the unique structures and unsaturated coordination environments of single atoms can be effectively harnessed to control magnetic properties. In this research, first investigation is presented into regulation properties through states atoms. Magnetic single‐atom one‐dimensional materials, M‐N‐C/ZrO 2 (M = Fe, Co, Ni), with varying are design synthesize based on orbital structure model. The SAs 3 d electron composite M‐N‐C...
Whether coat proteins play a widespread role in endocytic recycling remains unclear. We find that ACAP1, GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6, is part of novel clathrin complex regulated by ARF6 two key physiological settings, stimulation-dependent integrin critical cell migration and insulin-stimulated glucose transporter type 4 (Glut4), which required homeostasis. These findings not only advance basic understanding an early mechanistic step but also shed...
Prunus tomentosa seeds were researched for antioxidant and anti-inflammatory constituents. By activity-guided fractionation of P. seed extract, six new dihydrobenzofuran neolignans, prunustosanans AI-IV (1–4) prunustosanansides AI AII (5 6), together with 10 known compounds (7–16) isolated from bioactive fraction. The structures determined by spectroscopic analyses, especially NMR, HRESIMS, CD spectra. activity was greatest 5, 10, 12 against DPPH radical 8, 9, 13 ABTS radical. Moreover, 7 11...
During the process of manufacturing hawthorn (Crataegus pinnatifida) juice and jam, a significant quantity byproducts (leaves, seeds) is generated. The antioxidant anti-inflammatory bioassay-guided fractionation extract seeds has led to isolation eight new lignans, hawthornnins A-H (1-8), seven known analogues (9-15). Their structures were elucidated by spectroscopic techniques, including 1D 2D NMR CD spectra. radical-scavenging effects all isolated compounds investigated. 1-6 8 showed...
Eleucanainones A and B are two structurally complex naphthoquinone-derived dimers whose structure identification is difficult. Large yellow fragments of the preliminary CASE (computer-assisted elucidation) analysis revealed that original structures might be questionable. Structural revisions compounds were proposed on basis NMR analysis, methods, conformation DFT (density functional theory) calculations with a custom DP4+ analysis. In addition, polyketide-folded biosynthetic pathway revised...
Unprecedented sesquiterpenoid scaffolds, furnished by unexpected carbon–carbon linkage formation or cleavage, were targeted and isolated from Daphne aurantiaca following an integrated strategy.
Pepper (Piper nigrum L.) is a widely used spice plant known for its fruits and roots, which serve as flavor enhancers in culinary applications hold significant economic value. Despite the popularity of pepper fruits, their roots remain relatively understudied, with limited research conducted on bioactive components. This study focused discovering separating primary amide alkaloids found roots. The process involved using antioxidant activity crude fractions Global Natural Products Social...
Demand for the exploration of botanical pesticides continues to increase due detrimental effects synthetic chemicals on human health and environment development resistance by pests. Under guidance a bioactivity-guided approach HSQC-based DeepSAT, 16 coumarin derivatives were discovered from leaves
Thioredoxin reductase 1 (TrxR1) is an important therapeutic target for nonsmall cell lung cancer (NSCLC) treatment due to its overexpression in NSCLC cells. In this work, address the deficiency that sesquiterpene lactone containing α-methylene-γ-lactone moiety was rapidly metabolized by endogenous nucleophiles, series of novel thioether derivatives were designed and synthesized based on a reactive oxygen species (ROS)-triggered prodrug strategy. Among them, 5u exhibited potent cytotoxicity...
Highly oxidized germacranolides are mainly found in the genus Elephantopus, contain a characteristic ten-membered molecular core that is highly flexible, and exhibit potential cytotoxic properties. However, their configurations were assigned ambiguously previous reports due to spectroscopic observation of macrocyclic systems. Herein, 17 germacranolides, including 12 new (1–12), isolated from Elephantopus tomentosus. Their structures characterized by data analysis combined with X-ray...
Phytochemical investigation on the seeds of hawthorn (Crataegus spp.) led to isolation a new compound, (7'R, 8'R, 8S)-isolariciresinol (1), along with six known compounds (2-7). The structures all were determined based spectroscopic data interpretation. Aβ1-42 inhibition activity isolated was evaluated in vitro. As result, 5 and 6 showed stronger aggregation than curcumin, rates 70.59 68.14% at 20 μM. possible mechanism interaction between active also investigated by molecular docking.
Abstract Main observation and conclusion Quassinoids, a class of highly oxygenated triterpenes, have been isolated as bitter principles from the plants Simaroubaceae family. Five new quassinoids, chouchunlactone A—E (1 — 5 ), two known ones were identified root barks Ailanthus altissima Swingle (Simaroubaceae). The chemical structures compounds deduced by spectroscopic data analyses, NMR calculations DP4+ probability analysis. absolute configurations defined comparison their experimental...