A5105517448- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Diet and metabolism studies
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Muscle metabolism and nutrition
- Tree Root and Stability Studies
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Forest Biomass Utilization and Management
- Metabolism, Diabetes, and Cancer
- Ginseng Biological Effects and Applications
- Control Systems in Engineering
- Peroxisome Proliferator-Activated Receptors
- Radiomics and Machine Learning in Medical Imaging
- Lipid metabolism and disorders
- Bioenergy crop production and management
- Hydrological Forecasting Using AI
- Advanced Sensor and Control Systems
- Dietary Effects on Health
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Reproductive System and Pregnancy
Yale University
2018-2025
Harbin Medical University
2019-2024
First Affiliated Hospital of Harbin Medical University
2019-2024
First Affiliated Hospital of Wannan Medical College
2019-2024
Wannan Medical College
2019-2024
Beijing Forestry University
2022-2024
State Forestry and Grassland Administration
2022
Qingdao University
2021
Qingdao Municipal Hospital
2021
Henan Polytechnic University
2020
Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin resistance despite increasing circulating nonesterified acids (NEFA), the main substrate for synthesis intrahepatic triglycerides (IHTG). To explore underlying mechanism, we quantified hepatic mitochondrial fluxes their regulators humans using positional isotopomer NMR tracer analysis. Ten overweight/obese subjects received stable isotope...
The athlete’s paradox states that intramyocellular triglyceride accumulation associates with insulin resistance in sedentary but not endurance-trained humans. Underlying mechanisms and the role of muscle lipid distribution composition on glucose metabolism remain unclear. We compared highly trained athletes (ATHL) normal weight (LEAN) overweight-to-obese (OVWE) male female individuals. This observational study found ATHL show higher sensitivity, mitochondrial content, capacity, lower...
Rosa banksiae, known as Lady Banks' rose, is a perennial ornamental crop and versatile herb in traditional Chinese medicine. Given the lack of genomic resources, we assembled HiFi Nanopore sequencing-derived 458.58 Mb gap-free telomere-to-telomere high-quality R. banksiae genome with scaffold N50 = 63.90 Mb. The exhibited no lineage-specific whole-genome duplication compared other Rosaceae. phylogenomic analysis 13 Rosaceae Arabidopsis through comparative genomics study showed that numerous...
Oestrogen has been shown to play an important role in the regulation of metabolic homeostasis and insulin sensitivity both human rodent studies. Insulin is greater premenopausal women compared with age-matched men, metabolism-related cardiovascular diseases type 2 diabetes are less frequent these same women. Both female male mice treated oestradiol protected against obesity-induced resistance. The protection resistance associated reduced ectopic lipid content liver skeletal muscle. These...
Meal ingestion increases body temperature in multiple species, an effect that is blunted by obesity. However, the mechanisms responsible for these phenomena remain incompletely understood. Here we show refeeding plasma leptin concentrations approximately 8-fold 48-hour-fasted lean rats, and this normalization of stimulates adrenomedullary catecholamine secretion. Increased adrenal medulla-derived catecholamines were necessary sufficient to increase postprandially, a process required both...
White adipose tissue (WAT) insulin action has critical anabolic function and is dysregulated in overnutrition. However, the mechanism of short-term high-fat diet-induced (HFD-induced) WAT resistance (IR) poorly understood. Based on recent evidences, we hypothesize that a HFD causes IR through plasma membrane (PM) sn-1,2-diacylglycerol (sn-1,2-DAG) accumulation, which promotes protein kinase C-ε (PKCε) activation to impair signaling by phosphorylating receptor (Insr) Thr1160. To test this...
Athletes exhibit increased muscle insulin sensitivity, despite intramuscular triacylglycerol content. This phenomenon has been coined the 'athlete's paradox' and is poorly understood. Recent findings suggest that subcellular distribution of sn-1,2-diacylglycerols (DAGs) in plasma membrane leading to activation novel protein kinase Cs (PKCs) a crucial pathway inducing resistance. Here, we hypothesised regular aerobic exercise would preserve sensitivity by preventing increases sn-1,2-DAGs PKCε...
Microsomal triglyceride transfer protein (MTTP) deficiency results in a syndrome of hypolipidemia and accelerated NAFLD. Animal models decreased hepatic MTTP activity have revealed an unexplained dissociation between steatosis insulin resistance. Here, we performed comprehensive metabolic phenotyping liver-specific knockout (L-
The branch impact failure mechanism has gradually received attention from scholars, along with the application of cutting methods in plantation forest pruning. In this paper, Populus tomentosa branches was mainly studied. process simulated by using Finite Element Method (FEM)-based explicit dynamics. stress change and deformation characteristics were A theoretical model diameter, clearance, angle as main factors proposed. describes damage changing force. state equation proposed to describe...
Standing tree pruning in fast-growing forests is an essential part of the targeted nurturing quality forests. Because high risk and low efficiency traditional methods, a climbing robot was developed, its design optimized, related experimental research carried out. This paper describes scheme Monkeybot mechanical structure control system theoretically analyzes clamping mechanism, walking cutting obstacle avoidance mechanism to determine critical parameters. On premise ensuring good effect,...
Diacylglycerol (DAG) has been proposed to mediate lipid-induced hepatic insulin resistance. Accumulated DAG activates PKCε which phosphorylates receptor kinase (IRK) at T1160 inhibit IRK activation and cause However, the importance of in resistance remains controversial. To test physiological effect acute accumulation on sensitivity, we used antisense oligonucleotide (ASO) specifically diglyceride acyltransferase 2 (DGAT2) catalyzes conversion triglyceride. Previously, chronic DGAT2...
<title>Abstract</title> Background: Evidence regarding the health effects of saturated fatty acids (SFAs), monounsaturated (MUFAs), and total polyunsaturated (PUFAs) is controversial. Our objective was to explore associations between serum-free mortality among cancer survivors. Methods: The study included 6,575 participants with or without diagnosis aged 20 years older a who were recruited before December 2014 followed up through 31, 2019. Hazard ratios (HRs) 95% confidence intervals (CIs)...
<title>Abstract</title> The accuracy of runoff forecasting is influenced by factors, such as the type prediction model and parameter settings. To account for these uncertainties leverage strengths different models, in this study, we developed an ensemble model. It assigned combination weights to each based on its accuracy, improving short-term forecasts. Using daily data from Dongqiaoyuan Hydrological Station Rongjiang River Basin, China, six models were established coupling empirical mode...
In order to improve the position control accuracy of rodless cylinder, valve cylinder system based on pneumatic proportional servo is studied deeply. According working principle mechanical system, under condition uniform speed, driving voltage changed measure multiple sets friction force and corresponding velocity data. Analyzed physical structure each component in established mathematical model introduced MATLAB identification toolbox identify parameters transfer function. experiment...
White adipose tissue (WAT), as an energy storage organ, plays a major role in regulating peripheral insulin resistance and hepatic gluconeogenesis, but the mechanism by which lipid induces WAT is poorly understood. To examine potential of diacylglycerol (DAG) - protein kinase Cε (PKCε) receptor (INSR) pathway mediating lipid-induced resistance, we assessed action liver, muscle 7-day high fat diet (HFD) regular chow (RC) fed rats hyperinsulinemic-euglycemic clamp (HEC) combined with [3-3H]...
Day care practice at children′s specialist hospitals can improve the quality of for children patients.The hospital adopted such means as improving service management and regulations, process day care, creating green channel , moving forward extending service.Their proved that mode significantly shorten waiting time hospitalization, cut back medical costs, experience their family, achieve all-win community-hospital-patient . Key words: Hospitals, specialist; Children; Day care; Clinical
The identity and subcellular localization of the bioactive lipid species that causes hepatic insulin resistance remain controversial. Though chronic diacylglycerol acyltransferase 2 (DGAT2) knockdown improves steatosis action, we hypothesized acute DGAT2 would transiently increase (DAG) content to specifically assess role DAG on action. Regular chow-fed rats were treated with a single dose antisense oligonucleotide studied days later. sn-1,2, sn-2,3 sn-1,3 DAGs assessed by LC-MS/MS in...
The mechanism by which meal ingestion causes thermogenesis remains unknown. Here we show that refeeding leads to a 10x increase in plasma leptin concentrations associated with 2.5x catecholamine 48h-fasted lean rats. This leptin/catecholamine surge was 1°C body temperature (BT) (fed 35.9±0.1°C, fasted 35.4±0.0°C, P&lt;0.001; refed 36.4±0.1°C, P&lt;0.001 vs. and P&lt;0.05 fed). Leptin infusion rats replicated these increases epinephrine BT. However, the effect of BT abrogated...
Nonalcoholic fatty liver disease (NAFLD) is strongly associated with hepatic insulin resistance (HIR), however the key lipid species and molecular mechanisms linking these conditions are widely debated. In order to address questions, we examined metabolic impact of a liver-specific antisense oligonucleotide against PKCε found that knockdown ameliorated high-fat diet-induced HIR in rats, reflected by ∼2x increase insulin-stimulated glycogen synthesis rate improved insulin-mediated suppression...