A5060523963- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Nutrition and Health in Aging
- Cardiovascular and exercise physiology
- Metabolism, Diabetes, and Cancer
- Muscle metabolism and nutrition
- Thyroid Disorders and Treatments
- Alcohol Consumption and Health Effects
- Growth Hormone and Insulin-like Growth Factors
- Calpain Protease Function and Regulation
- Cancer, Hypoxia, and Metabolism
- Diabetes Treatment and Management
- Body Composition Measurement Techniques
- Cardiovascular Function and Risk Factors
- Exercise and Physiological Responses
- Heart Rate Variability and Autonomic Control
- Fibroblast Growth Factor Research
- HIV-related health complications and treatments
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
Deutsches Diabetes-Zentrum e.V.
2023-2025
German Center for Diabetes Research
2023-2025
Heinrich Heine University Düsseldorf
2023-2025
Hochschule Düsseldorf University of Applied Sciences
2024
The athlete’s paradox states that intramyocellular triglyceride accumulation associates with insulin resistance in sedentary but not endurance-trained humans. Underlying mechanisms and the role of muscle lipid distribution composition on glucose metabolism remain unclear. We compared highly trained athletes (ATHL) normal weight (LEAN) overweight-to-obese (OVWE) male female individuals. This observational study found ATHL show higher sensitivity, mitochondrial content, capacity, lower...
Highlights•Glycemia and liver lipid content jointly affect the adaptation of hepatic oxidative capacity to insulin resistance•Prediabetes affects signaling, mitochondrial dynamics relates fibrosis prevalence•Fasting plasma glucose predicts decline plasticity more robustly than 2-hour OGTT glucoseAbstractBackground & AimsHepatic respiration is higher in steatosis, but lower overt type 2 diabetes. We hypothesized that OXPHOS increases with a greater degree resistance obesity, independent other...
Objective: New clustering approaches successfully distinguished between severe and moderate diabetes endotypes. It remains unclear if body composition differs We hypothesize that individuals with age-related (MARD) (i) have a lower fat free mass index (FFMI) higher (FMI) than would be expected from their BMI, sex age, (ii) exhibit worsening of phenotype during the early course diabetes.
High-intensity interval training (HIIT) generally improves cardiorespiratory fitness (VO2max), while it increases insulin sensitivity and secretion of small extracellular vesicles (sEV) mainly in resistant individuals without with type 2 diabetes (T2D). However, is unknown whether the HIIT-induced metabolic benefits are similarly sustained across people different degree glucose tolerance at 4 weeks after stopping HIIT intervention.
Hyperglycemia in type 2 diabetes (T2D) associates with higher glucagon secretion, which may be further promoted the presence of metabolic dysfunction-associated steatotic liver disease (MASLD). Thus, we compared fasting and prandial glucagonemia people without recent-onset T2D MASLD. Participants German Diabetes Study (GDS), (n=50; known duration <1 year) or normal glucose tolerance (NGT; n=50), underwent mixed meal tests (MMT; 365 kcal) hyperinsulinemic-normoglycemic clamps. Early...
Although type 2 diabetes closely associates with metabolic dysfunction-associated steatotic liver disease (MASLD) and accelerates its progression to steatohepatitis (MASH), fibrosis hepatocellular carcinoma (HCC), still no treatment has been approved for MASLD. The extracellular matrix proteoglycan, decorin (DCN) may protect against HCC, but role in MASLD is yet unclear. Thus, we treated mice 8 w recombinant human DCN (200 μg/kg/day) or phosphate-buffered saline (PBS) via subcutaneous...
Common insulin resistance relates to positive energy balance and is central obesity, type 2 diabetes metabolic dysfunction-associated steatotic liver disease (MASLD). In early MASLD, the adapts increased supply by upregulating its oxidative phosphorylation (OXPHOS) capacity (mitochondrial plasticity), which lost during MASLD progression in diabetes. This study examined whether improvements sensitivity after bariatric surgery restore hepatic mitochondrial plasticity thereby ameliorate...
Introduction & Objective: The severe insulin resistant diabetes (SIRD) endotype associates with markedly higher risk of metabolic dysfunction associated steatotic liver disease (MASLD). However, it is not known if ectopic lipid deposition also in skeletal muscle or adipose tissue compartments than other endotypes. Methods: Participants (n=697, duration <1 y) the prospective German Diabetes Study (GDS) underwent 1H magnetic resonance spectroscopy for quantifying intramyocellular...