A5102879385- Lung Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Cerebral Palsy and Movement Disorders
- Thyroid Cancer Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Parasitic Infections and Diagnostics
- Neonatal and fetal brain pathology
- Trauma Management and Diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Toxoplasma gondii Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Bone health and treatments
- Single-cell and spatial transcriptomics
- Respiratory Support and Mechanisms
- Thyroid and Parathyroid Surgery
- Head and Neck Surgical Oncology
- Cytomegalovirus and herpesvirus research
- Bone Metabolism and Diseases
- Inflammasome and immune disorders
- Sustainable Industrial Ecology
- Neurogenesis and neuroplasticity mechanisms
Jiangsu University
2023-2024
Shanghai University of Traditional Chinese Medicine
2024
Fudan University
2008-2023
China Pharmaceutical University
2017-2022
Shanghai Pulmonary Hospital
2015-2021
Tongji University
2015-2021
Hangzhou First People's Hospital
2021
Heze Municipal Hospital
2020
First Affiliated Hospital of Xi'an Jiaotong University
2019-2020
Xi'an Jiaotong University
2019
Malignant transformation and progression of cancer are driven by the co-evolution cells their dysregulated tumor microenvironment (TME). Recent studies on immunotherapy demonstrate efficacy in reverting anti-tumoral function T cells, highlighting therapeutic potential targeting certain cell types TME. However, functions other immune remain largely unexplored.We conduct a single-cell RNA-seq analysis isolated from tissue samples non-small lung (NSCLC) patients, identify subtypes...
Uniportal video-assisted thoracic surgery (VATS) is well accepted by surgeons for anatomical major lung resections. However, large series evaluating the results, safety and efficacy of technique sleeve resections are still lacking. The aim this study was to examine our experience with use uniportal VATS resections.From September 2014 January 2018, a total 79 consecutive patients were offered resection centrally located tumours invading orifice lobar bronchus or extending into main stem...
The aim of this article is to present a thoracoscopic technique extended thymectomy through subxiphoid incision. Six consecutive patients were successively treated with approach, which provided good view the bilateral pleural cavities. procedure safe and technically feasible yields excellent cosmetic results. We believe that uniportal approach satisfactory for performing in well selected patients.
Abstract Background Chronic inflammation plays a crucial role in developing various cardiovascular and metabolic disorders. Obstructive sleep apnea (OSA) is unique condition characterized by the coexistence of disturbances, where chronic may exacerbate disease progression severity. This study investigated how different hematological inflammatory cells mediators can serve as predictive indicators severe OSA. Methods In retrospective cohort study, 150 patients suspected having obstructive...
Food allergy (FA) poses a growing global food safety concern, yet no effective cure exists in clinics. Previously, we discovered potent antifood compound, butyrolactone I (BTL-I,
Abstract Background and objectives Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition, often complicated by frequent exacerbations increased mortality risk. COPD patients also had higher risk for developing diabetes mellites. Recently, the studies showed promising utility of HbA1C in identifying at heightened critical illnesses. This study evaluated diagnostic prognostic value glycated hemoglobin (HbA1c) predicting exacerbation short-term mortality. Methods A...
Nipah virus is a deadly paramyxovirus with 40-75% mortality and >750 cases since 1998. Currently there are no clinically approved vaccines or therapeutics to target infection. an enveloped two surface glycoproteins, the trimeric fusion (F) tetrameric attachment glycoprotein (G). G responsible for cellular via binding ephrin B2/B3. Glycosylation of its effects on receptor engagement has not previously been studied but important as glycosylation impacts immunogenicity, structural...
Chemokines and chemokine receptors are likely to play important roles in the pathogenesis of Epstein-Barr virus (EBV) -associated disease. The primary EBV infection occurs oropharynx where infects mainly tonsillar B cells. We have previously shown that CXCR4 expression on cells is modulated by EBV. Here, CXCR5 CCR7 expression, which for migration into lymphoid tissue, was followed 14 days after Early (2 days) there were only minor changes expression. However, at day 7 CXCR5, as well CCR7,...
Uniportal subxiphoid video assisted bilateral segmentectomy is a minimally invasive option for the treatment of synchronous lung lesions. Its advantages over conventional multiportal or uniportal thoracoscopic surgery include avoidance damage to intercostal neurovascular bundle and allowance lesion resection as combined procedure via single incision. This article presents case from our centre describe surgical technique this procedure.
Lung cancer remains the leading cause of cancer-related death worldwide. adenocarcinoma (LUAD) is thought to be caused by precursor lesions atypical adenoma-like hyperplasia and may have extensive in situ growth before infiltration. To explore relevant factors heterogeneity evolution lung subtypes, authors perform single-cell RNA sequencing (scRNA-seq) on tumor normal tissue from five multiple nodules' LUAD patients conduct a thorough gene expression profiling cells their microenvironment at...
Abstract Background Severe COVID-19 disease is typically associated with an urgent need for supplemental oxygen therapy that may be successfully delivered through conventional methods or require invasive mechanical ventilation. Early prediction of the ventilation could significantly improve outcomes patients. Plasma levels D-dimer and a number inflammatory markers as well values complete blood counts, all measured in first two days hospital admission patients, were evaluated their...
ABSTRACT We report that type I interferons (IFNs) upregulate latent membrane protein 1 (LMP-1) expression by direct activation of the ED-L1 promoter in several Epstein-Barr virus (EBV)-carrying Burkitt's lymphoma lines. In EBV-infected primary B cells, IFN-α transiently upregulates LMP-1 mRNA, but not levels, followed downregulation both, suggesting a novel antiproliferative mechanism IFNs. Furthermore, our results may explain memory cells systemic lupus erythematosus patients.
Uniportal video-assisted thoracoscopic surgery (VATS) although considered less invasive than the multi-port techniques, is still an intercostal approach, resulting in nerve injury. Recently, some surgeons have tried to address this problem by attempting a subxiphoid approach. The aim of our study was assess and compare results between uniportal VATS lobectomy terms postoperative pain quality life (QoL).Patients from January 2014 2018 undergoing were prospectively assessed for QoL at 1, 3, 6...
Diffuse large B-cell lymphoma (DLBCL), the most common type of malignant lymphoma, accounts for 30% adult non-Hodgkin lymphomas. Epstein-Barr virus (EBV) -positive DLBCL elderly is a newly recognized subtype that 8-10% DLBCLs in Asian countries, but less Western populations. Five DLBCL-derived cell lines were employed to characterize patterns EBV latent gene expression, as well response cytokines and chemotaxis. Interleukin-4 interleukin-21 modified LMP1, EBNA1 EBNA2 expression depending on...
Abstract The clinical features of EBV-positive diffuse large B cell lymphoma (DLBCL) indicate a poorer prognosis than EBV-negative DLBCL. Currently, there is no efficacious drug for cytokine interleukin-21 (IL-21) has been reported to be pro-apoptotic in DLBCL lines and being explored as new therapeutic strategy this type lymphomas. However, our previous studies showed that IL-21 stimulation leads increased proliferation. Here, analysis rare sample DLBCL, combination with NOD/SCID mouse...
Abstract 7-Met, a derivative of soybean isoflavone, is natural flavonoid compound that has been reported to have multiple signaling pathways regulation effects. This study investigated the therapeutic effects 7-Met on mice with atopic dermatitis induced by fluorescein isothiocyanate (FITC), or oxazolone (OXZ). ameliorated FITC OXZ-induced symptoms decreasing ear thickness, spleen index, mast cell activation, neutrophil infiltration and serum IgE levels in female BALB/c mice. In FITC-induced...
Previously, interleukin (IL)-21 has been found to induce apoptosis by activating the signal transducer and activator of transcription 3 (STAT3) concomitant upregulation c-Myc in diffuse large B-cell lymphoma (DLBCL) lines with unknown Epstein-Barr virus (EBV) status. Here, as a first approach toward characterization role EBV DLCBL, gene expression IL-21 sensitivity EBV-positive DLBCL line, Farage, have examined. It was that, surprisingly, despite upregulation, induced cell proliferation...
Butyrolactone I (BTL-I) is a butanolide isolated from the deep-sea-derived fungus, Aspergillus sp. It provides potential new target for prevention and treatment of food allergies. This study aimed to investigate metabolic pharmacokinetic profile BTL-I in rats. The profiles were obtained by UHPLC-Q-TOF-MS. As result, eleven metabolites structurally identified, proposed pathways characterized. main oxidative glucuronidative metabolites. In addition, sensitive UHPLC-MS/MS method was established...