A5101363283- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Healthcare and Venom Research
- Acupuncture Treatment Research Studies
- Menstrual Health and Disorders
- Mitochondrial Function and Pathology
- Immune cells in cancer
- Speech and Audio Processing
- Acoustic Wave Phenomena Research
- High Entropy Alloys Studies
- Erythrocyte Function and Pathophysiology
- Cancer Mechanisms and Therapy
- Chromatin Remodeling and Cancer
- Energy, Environment, Economic Growth
- Cancer, Hypoxia, and Metabolism
- Microbial Community Ecology and Physiology
- Blood disorders and treatments
- Corporate Social Responsibility Reporting
- interferon and immune responses
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- High-Temperature Coating Behaviors
- Environmental Sustainability in Business
- Hemoglobinopathies and Related Disorders
BGI Research
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Soochow University
2025
Second Affiliated Hospital of Soochow University
2025
Beijing Graphene Institute
2025
Harbin Medical University
2025
Second Affiliated Hospital of Harbin Medical University
2025
Institute of Hematology & Blood Diseases Hospital
2024
Hebei University of Chinese Medicine
2024
Zhejiang University
2024
Regulatory T (Treg) cells play a critical regulatory role in the immune system by suppressing excessive responses and maintaining balance. The effective migration of Treg is crucial for controlling development progression inflammatory diseases. However, mechanisms responsible directing into tissue remain incompletely elucidated. In this study, we identified BAF60b, subunit switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complexes, as positive regulator cell that inhibits...
Abstract Inherited non-hemolytic anemia is a group of rare bone marrow disorders characterized by erythroid defects. Although concerted efforts have been made to explore the underlying pathogenetic mechanisms these diseases, understanding causative mutations are still incomplete. Here we identify in diseased pedigree that gain-of-function mutation toll-like receptor 8 ( TLR8 ) implicated inherited anemia. expressed lineage and erythropoiesis impaired activation whereas enhanced inhibition...
Hepatocellular carcinoma is one of the most challenging malignancies and has high incidence mortality rates worldwide. Digital subtraction angiography (DSA)-guided hepatic arterial infusion standard chemotherapeutic agent oxaliplatin (OXA) advantages both precision efficacy, making it an important therapeutic strategy for advanced-stage liver cancer. However, patients receiving this treatment still face severe systemic toxicity poor tolerability oxaliplatin. In study, we compared with novel...
Penile squamous cell carcinoma (PSCC) is a highly aggressive malignancy without effective treatment due to limited knowledge of its development and tumor microenvironment (TME). In this study, single-nucleus RNA sequencing (snRNA-seq) high-resolution spatial transcriptomics are employed comprehensively investigate the trajectories TME. The results revealed that PSCC cells mimicked differentiation tissue organization normal penile epithelium, independent human papillomavirus (HPV) infection...
Superscattering is a unique wave phenomenon that allows subwavelength objects to produce large scattering cross section, surpassing the fundamental single-channel limit. This effect has been extensively studied in many systems, such as electromagnetic waves, water surface and airborne acoustics. However, context of underwater acoustics, achieving superscattering with single material remained unexplored due complex acoustic-solid interactions. Here, we have inversely designed simple yet...
Using data from China A-share non-financial listed firms and mutual funds between 2010–2020, we investigate green investors' impact on corporate innovation. Consonant with the received literature, find a significant incentivization effect, where shareholders positively influence innovation by improving governance mitigating financial constraints. This result suggests that is more pronounced in realm of utility within state-owned enterprises.
Seawater intrusion has a significant impact on the irrigation quality of agricultural water, thereby posing threat to plant growth and development. We hypothesized that rhizosphere tea plants harbors beneficial microorganisms, which may improve tolerance seawater stress. This study utilized 16s ITS techniques analyze microbial community shifts in non-rhizosphere under stress conditions. The findings suggest leads reduction diversity, although diversity stressed soils showed relatively higher...
Abstract Lactate dehydrogenase (LDH) stands at the intersection of pyruvate metabolism. While it is believed that inhibition LDH redirects to mitochondrial metabolism, suppressing glycolysis and boosting oxidative phosphorylation, mechanism remains largely unexplored. We found individual A or B knockouts had minimal impact on glycolysis, tricarboxylic acid cycle (TCAC), phosphorylation (OXPHOS). However, combining knockout with inhibitor GNE-140 significantly suppressed these processes....