A5077597475- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Oxidative Organic Chemistry Reactions
- Traditional and Medicinal Uses of Annonaceae
- Crystallography and molecular interactions
- Microbial Natural Products and Biosynthesis
- Chemical synthesis and alkaloids
- Asymmetric Synthesis and Catalysis
- Catalytic Alkyne Reactions
- Advanced Synthetic Organic Chemistry
- Catalytic C–H Functionalization Methods
- Alkaloids: synthesis and pharmacology
- Cyclopropane Reaction Mechanisms
- Carbohydrate Chemistry and Synthesis
- Axial and Atropisomeric Chirality Synthesis
- Bioactive Natural Diterpenoids Research
- Bioactive Compounds and Antitumor Agents
- Cancer Treatment and Pharmacology
- Synthesis of Indole Derivatives
- Advanced Memory and Neural Computing
- Phytochemistry and Bioactivity Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Chemical Synthesis and Analysis
Southern University of Science and Technology
2016-2025
Wenzhou University
2024-2025
Advanced Research Institute
2025
Guangdong Institute of Intelligent Manufacturing
2024
Guangdong Academy of Sciences
2024
Zhengzhou University of Light Industry
2023-2024
Shenzhen Bay Laboratory
2022-2024
Wuyi University
2024
IRD Fuel Cells (Denmark)
2024
Changsha University of Science and Technology
2024
With the continuous development of computers, communication technology, and regional medical collaboration services, security confidentiality information are becoming more important. In order to prevent illegal leakage sensitive patient information, it is great significance study image encryption. this article, a flux-controlled hyperbolic memristor model with locally active characteristics proposed, which has rich nonlinear characteristics. The parameters affect local activity memristor,...
A concise first total synthesis of (±) maoecrystal V (1) is reported. The features a Wessely oxidative dearomatization phenol, an intramolecular Diels−Alder reaction, and Rh-catalyzed O−H bond insertion as key steps.
Cortistatin A is a marine steroid with highly selective and perhaps mechanistically unique antiangiogenic activity. Herein we report synthesis of this natural product by way "cortistatinone", an intermediate ideally suited for investigating the key pharmacophore cortistatin family. The begins terrestrial traverses route to through discovery chemical reactivity. Specifically, demonstrate first example directed, geminal C−H bisoxidation, new fragmentation cascade access expanded B-ring...
Natural products containing bridged ring systems are widely identified and show significant biological activity. The development of efficient synthesis reactions strategies to construct is a long-standing but very challenge in organic chemistry. In 2014, our group developed unique type II [5 + 2] cycloaddition reaction that provides facile direct methodology for constructing highly functionalized bicyclo[4.3.1], bicyclo[4.4.1], bicyclo[5.4.1], bicyclo[6.4.1], other bicyclo[m.n.1] strained...
Taxol is one of the most famous natural diterpenoids and an important anticancer medicine. represents a formidable synthetic challenge has prompted significant interest from community. However, in all previous syntheses Taxol, there have been no reports closing desired eight-membered ring through C1–C2 bond formation. Furthermore, existence Taxol-resistant tumors side effects make development new approaches to synthesize its derivatives highly desirable. Here, we report asymmetric total...
The first total synthesis of (±)- and (-)-daphnillonin B, a daphnicyclidin-type alkaloid with new [7-6-5-7-5-5] A/B/C/D/E/F hexacyclic core, has been achieved. [6-5-7] B/C/D ring system was efficiently diastereoselectively constructed via mild type I intramolecular [5+2] cycloaddition, followed by Grubbs II catalyst-catalyzed radical cyclization. [5-5] fused E/F synthesized diastereoselective Pauson-Khand reaction. Notably, the synthetically challenging core reassembled unique...
Development of a gold-catalyzed tandem reaction 1,7-diynes with both internal and external nucleophiles was realized, which constructed five chemical bonds, two rings, stereogenic centers in single step. Based on the novel cascade transformation, we achieved unified strategy toward stereoselective total syntheses C-15 oxygenated drimane-type sesquiterpenoids their analogues, provided natural products kuehneromycin A, antrocin, anhydromarasmone, marasmene as proof-of-concept study.
Convergent approach: The total syntheses of (−)-flueggine A and (+)-virosaine B (see scheme) have been accomplished in a concise convergent manner. Key steps these approaches were relay ring-closing metathesis reactions for rapid construction the key intermediates, 1,3-dipolar cycloaddition formation natural products.
The first dearomative indole [5+2] cycloaddition reaction with an oxidopyrylium ylide resulted in efficient and diastereoselective construction of some highly functionalized synthetically challenging oxacyclohepta[b]indoles. protocol proceeds under very mild conditions, thus enabling high functional-group tolerance unique endo selectivity.
Abstract A type II intramolecular oxidopyrylium‐mediated [5+2] cycloaddition reaction allows the efficient and diastereoselective formation of various highly functionalized synthetically challenging bridged seven‐membered ring systems (such as bicyclo[4.4.1]undecane, bicyclo[4.3.1]decane, bicyclo[5.4.1]dodecane, bicyclo[6.4.1]]tridecane). This simple, thermal, direct transformation has a broad substrate scope is high yielding, with functional‐group tolerance unique endo selectivity. The...
A new method has been developed for the concise and asymmetric synthesis of seven humulanolides in 5–7 steps without need protecting groups. Notably, challenging 11-membered ring bridged butenolide moieties asteriscunolide D 6,7,9,10-tetrahydroasteriscunolide were introduced one step using a ring-opening/ring-closing metathesis cascade reaction. Asteriscunolide was used as versatile synthetic precursor to prepare asteriscunolides A–C via photoinduced isomerization reaction, asteriscanolide...
A highly concise, enantioselective synthesis of (−)-colchicine, the first syntheses (+)-demecolcinone and metacolchicine, was reported.
The first and asymmetric total synthesis of cyclocitrinol, an unusual C25 steroid, has been accomplished in a linear sequence 18 steps from commercially available compound 11. synthetically challenging bicyclo[4.4.1] A/B ring system with strained bridgehead (anti-Bredt) double bond cyclocitrinol was constructed efficiently diastereoselectively via type II intramolecular [5 + 2] cycloaddition.
A highly concise catalytic approach for the first asymmetric total syntheses of myrtucommuacetalones and callistrilones is reported.
In this review, we provide a summary of recent progress regarding synthetic studies towards natural products <italic>via</italic> [5 + 2] cycloaddition reactions.
The first asymmetric total synthesis of bioactive diterpenoid hypoestin A with an unprecedented [5-8-5-3] tetracyclic skeleton is accomplished in 15 steps from commercially available (R)-limonene. Furthermore, the second syntheses sesterterpenoids albolic acid and ceroplastol II 21 are also reported. synthetically challenging highly functionalized [X-8-5] (X = 5 or 7) tricarbocyclic ring systems found A, acid, II, schindilactone as well other natural products, efficiently directly...
The first and asymmetric total synthesis of bufogargarizins A B, two unusual highly oxygenated twin steroids with rearranged A/B rings, was achieved. synthetically challenging [7–5–6–5] tetracyclic ring system bufogargarizin efficiently constructed by the intramolecular Ru-catalyzed [5 + 2] cycloaddition reaction a vinyl ether cyclopropane-yne. Notably, interesting [5–7–6–5] skeleton B diastereoselectively reassembled unique retro-aldol/transannular aldol cascade reactions from framework.
Triplex DNA switches are attractive allosteric tools for engineering smart nanodevices, but their poor triplex-forming capacity at physiological conditions limited the practical applications. To address this challenge, we proposed a low-entropy barrier design to facilitate triplex formation by introducing hairpin duplex linker into motif, and resulting switch was termed as CTNS
The first type II intramolecular [3 + 2] annulation of allenylsilane-ene has been achieved, enabling diastereoselective and efficient construction synthetically challenging bridged five-membered ring systems such as bicyclo[3.2.1]. This mild direct process shows a broad substrate scope is highly stereospecific. Particularly, this work represents the stereoselective method for synthesis bicyclo[3.2.1] from acyclic precursors. Additionally, asymmetric total syntheses (+)- (−)-strepsesquitriol,...