A5100696914- Rheumatoid Arthritis Research and Therapies
- Pharmacological Effects of Natural Compounds
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Cancer, Lipids, and Metabolism
- Asthma and respiratory diseases
- Sepsis Diagnosis and Treatment
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Neonatal and Maternal Infections
- Spondyloarthritis Studies and Treatments
- Peroxisome Proliferator-Activated Receptors
- Ectopic Pregnancy Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Apelin-related biomedical research
- Sirtuins and Resveratrol in Medicine
- Photodynamic Therapy Research Studies
- Circular RNAs in diseases
- Cholesterol and Lipid Metabolism
- Inflammasome and immune disorders
Xiangnan University
2023-2025
Shaanxi Provincial People's Hospital
2025
Jiangxi Pingxiang People's Hospital
2020-2024
Wuhan University
2020-2024
Renmin Hospital of Wuhan University
2020-2024
Jinan University
2016-2024
Panyu District Central Hospital
2024
Hunan University of Traditional Chinese Medicine
2021-2023
Heilongjiang Bayi Agricultural University
2023
Academy of Military Medical Sciences
2023
Abstract Baicalin (7‐ d ‐glucuronic acid‐5, 6‐dihydroxyflavone) derived from the root of Scutellaria baicalensis used as Traditional Chinese Medicine (TCM) has been revealed to exert potential antiviral activity via various pathways, while molecular mechanisms have not fully understood. Pyroptosis, an inflammatory form programmed cell death (PCD), is reported play a crucial role in host fate during viral infection. In this study, transcriptome analysis mice lung tissue reveals that baicalin...
Abstract To explore the molecular network mechanism of Celastrol in treatment rheumatoid arthritis (RA) based on a novel strategy (integrated systems pharmacology, proteomics, transcriptomics and single-cell transcriptomics). Firstly, potential targets RA genes were predicted through database, Celastrol-RA obtained by taking intersection. Then, transcriptomic data proteomic collected. Subsequently, targets, differentially expressed genes, proteins imported into Metascape for enrichment...
Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate escape through interaction with PD-1 activated T lymphocytes (T cells). Previously, we reported that colon and breast stem (CSCs) much higher levels of PD-L1 than their parental cells, suggesting they will be more resistant immune attack.We investigated the underlining mechanism increase in CSCs, a special focus effect insulin epithelial growth factor (EGF), two fundamental...
Repeated implantation failure (RIF) is currently believed by some scholars to be mainly related the poor endometrial receptivity. Three-dimensional (3D) ultrasound, as a noninvasive examination, has attracted most attention. This paper further discusses whether 3D ultrasound of receptivity index guidance value in evaluation pregnancy outcomes patients with RIF following frozen-thawed embryo transfer.A total 79 were retrospectively analyzed. These which confirmed transvaginal ultrasonography...
Ferroptosis, a distinct form of cell death, is characterized by the iron-mediated oxidation lipids and finely controlled multiple cellular metabolic pathways. These pathways encompass redox balance, iron regulation, mitochondrial function, as well amino acid, lipid, sugar metabolism. Additionally, various disease-related signaling also play role in regulation ferroptosis. In recent years, with introduction concept ferroptosis deepening research on its mechanism, closely related to biological...
A decreased plasma level of soluble form the receptor for advanced glycation end products (sRAGE) in patients with Alzheimer's disease (AD) has been reported. However, no evidence shown whether sRAGE AD may differentiate from other types dementia.Our study assessed concentrations following 121 individuals Chongqing area: 36 AD, 12 vascular dementia (VaD), 14 mixed (MD), 24 (OD) including Parkinson's dementia, frontotemporal paralytic and 35 cognitively normal controls. The total was...
Background: Alcoholic fatty liver disease (AFLD) defines an important stage in the progression of alcoholic (ALD), which is a major cause morbidity and mortality worldwide. Objective: To establish mouse model AFLD. Methods: Male C57BL/6 mice were divided into following two groups: (i) control group, was allowed free access to food water (ii) alcohol-treated administered 15% (v/v) alcohol solution instead water. After 8–9 months treatment, serum biochemical indexes, histopathological changes,...