A5100352217- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- interferon and immune responses
- Sphingolipid Metabolism and Signaling
- Lung Cancer Research Studies
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Liver physiology and pathology
- Animal Nutrition and Physiology
- Peroxisome Proliferator-Activated Receptors
- Fibroblast Growth Factor Research
- Transcranial Magnetic Stimulation Studies
- Kruppel-like factors research
- Advanced MRI Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Macrophage Migration Inhibitory Factor
- Hepatitis C virus research
- Galectins and Cancer Biology
- Eicosanoids and Hypertension Pharmacology
- Spinal Fractures and Fixation Techniques
- Animal Disease Management and Epidemiology
- Nuclear Receptors and Signaling
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
Capital Medical University
2013-2025
Shaanxi Provincial People's Hospital
2025
Chinese Academy of Agricultural Sciences
2023-2024
Beijing Chest Hospital
2023
China Rehabilitation Research Center
2023
Peking University
2018
Peking University First Hospital
2018
Eye & ENT Hospital of Fudan University
2016
Shanghai Institute of Hypertension
2014
Background Recent genome-wide association (GWA) studies in Caucasians identified multiple single nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD). The associations of those SNPs myocardial infarction (MI) have not been replicated Asian populations. Among previously SNPs, we selected nine (rs10953541, rs1122608, rs12190287, rs12413409, rs1412444, rs1746048, rs3798220, rs4977574, rs579459, or near genes 7q22, LDLR, TCF21, CYP17A1, LIPA, CXCL12, LPA, CDKN2A, ABO,...
Abstract Chinese hamster with characteristics is used in experiments, and it of great value the field medical biology research. However, at present, there no high‐efficiency method for evaluating genetic quality hamsters. Here, we developed a novel detection system using single‐nucleotide polymorphism (SNP) markers. To find SNP loci, conducted whole genome sequencing on 24 Then, employed an locus screening criterion that set up previously initially screened 214 loci wide distribution high...
Background . Long noncoding RNAs (lncRNAs) were recently shown to have potential in the diagnosis and prognosis for numerous cancers. lncRNA GAS8-AS1 is decreased papillary thyroid cancer (PTC) tissue, but its plasma expression clinical value patients with PTC remain unknown. Materials Methods We investigated profile of 97 39 nodular goiter by quantitative real-time polymerase chain reaction. Results was downregulated comparison those goiters (<mml:math...
15-Deoxy-Δ 12,14 -Prostaglandin J 2 (15d-PGJ ), a natural peroxisome proliferator-activated receptor gamma (PPAR-γ) ligand, has been implicated as new antiinflammatory compound with possible clinical applications. Based on this concept, study was designed to evaluate the effects of 15d-PGJ bone marrow–derived monocyte/macrophage (BMM) migration, phagocytosis, and cytokine expression after liver injury using mouse models induced by cholestasis or carbon tetrachloride. Mice were lethally...
Pig diseases seriously threaten the health of pigs and benefits pig production. Previous research has indicated that Chinese native pigs, such as Min (M) pig, a better disease resistance ability than Large White (LW) pigs. However, molecular mechanism this is still unclear. In our study, we used serum untargeted metabolomics proteomics, interrogated to characterize differences in immunities between six resistant susceptible raised same environment. A total 62 metabolites were identified...
Small cell lung cancer (SCLC) stands as one of the most lethal malignancies, characterized by a grim diagnosis and prognosis. The emergence multi-drug resistance poses significant hurdle to effective therapy. Although previous studies have implicated long noncoding RNA LYPLAL1-DT in tumorigenesis SCLC, precise role highly expressed SCLC chemoresistance underlying mechanism remain inadequately understood.
Abstract Background Multichannel tactile stimulation devices is need to investigate human finger population receptive field (pRF) characteristics in the primary somatosensory cortex during functional magnetic resonance imaging (fMRI). Purpose To accurately characterize right‐hand representation based on Bayesian pRF model. Study Type Prospective. Population A water phantom and six healthy participants (four males, mean 23.8 years old). Field Strength/Sequence T1‐weighted...
Recent studies raise the possibility that eukaryotic translation elongation factor 1 alpha (eEF1A) may play a role in metabolism. One isoform, eEF1A2, is specifically expressed skeletal muscle, heart and brain. It regulates signal transduction. Nonetheless, eEF1A2’s function muscle glucose metabolism remains unclear. In present study, suppression subtractive hybridisation showed decrease Eef1a2 transcripts of diabetic Mongolian gerbils. This was confirmed at mRNA protein levels...
Oral cancer is considered one of the most malignant types tumors and known for its high likelihood recurrence metastasis. During clinical treatment, patients with oral often develop resistance to chemotherapy, making treatment process challenging. The purpose this study was investigate genes related chemotherapy their mechanisms in patients.
Small cell lung cancer (SCLC) is one of the most malignant tumors that has an extremely poor prognosis. RNA-binding protein (RBP) and long noncoding RNA (lncRNA) have been shown to be key regulators during tumorigenesis as well tumor progression. However, role RBP ELAVL4 lncRNA LYPLAL1-DT in SCLC remains unclear. In this study, we verified acts oncogenic was confirmed vitro vivo. Mechanistically, negatively regulates expression miR-204-5p, leading upregulation PFN2, thus, promoting...
The quality of pig backfat affects both pork and consumer preferences. Fatty acids (FAs) are crucial in determining the quality. This study assessed effect FAs on identified candidate genes associated with these FAs. differential fatty (DFAs) were compared pigs varying firmness four DFAs-caproic acid, stearic linoleic acid alpha-linolenic acid-were selected based T-tests (
Objective To explore the effect of endogenous sulfur dioxide (SO2) on apoptosis induced by cobalt chloride (CoCl2) in human pulmonary arterial endothelial cells (HPAECs). Methods CoCl2 was used primary HPAECs to mimize hypoxia-induced cell apoptosis.The aspartate aminotransferase 1(AAT1), and key enzyme generating SO2 were over-expressed transfecting with lentivirus containing AAT1 cDNA.HPAECs divided into 4 groups: vehicle group, vehicle+ CoCl2 group AAT1+ group.The expressions AAT1,...
Long noncoding RNAs (lncRNAs) regulate gene expression at different levels in various diseases, including type 1 diabetes (T1D). However, the of circulating lncRNAs leukocytes T1D has not been well documented. To identify differentially expressed between patients and healthy controls, RNA sequencing was performed on samples collected from both persons patients. The categories, enriched pathways, coexpression networks, characteristics novel were analyzed to provide an extensive profile. qPCR...
Objective To investigate the expression level and clinical significance of long non-coding RNA(LncRNA) growth arrest specific gene-antisense 1(GAS8-AS1) in papillary thyroid microcarcinoma(PTMC) patients. Methods We investigated profile GAS8-AS1 tissue samples patients with PTMC as well nodular goiter(NG) by quantitative real-time polymerase chain reaction(RT-qPCR). Results GAS8-AS1 cancer was down-regulated compared adjacent NG samples(P<0.05). Lower also correlated central...
旨在探究HMGA1基因在猪不同组织、不同日龄下不同品种中的表达谱，并对该基因编码区及3'UTR区的多态性与猪背膘厚进行关联分析。本研究利用实时荧光定量PCR检测大白猪HMGA1基因在7种组织的表达情况，及其在60、150和210日龄大白猪和民猪背部脂肪中的差异表达。对576头大白猪×民猪F2代资源群体的基因组DNA重测序进行HMGA1序列分析，筛选其编码区及3'UTR区SNPs，并以屠宰体重为协变量与背膘厚（第6~7肋）进行关联分析。结果表明，HMGA1 mRNA在大白猪不同组织中均有表达，且在组织间存在显著差异（P 0.05）。通过对F2群体HMGA1序列分析，在编码区检测出13个单核苷酸多态性（single nucleotide polymorphism，SNP）位点，其中包含2个错义突变位点：g.3261G>A和g.5818G>A，且g.3261G>A位点与背膘厚显著关联（P C和g.7280T>C与背膘厚显著关联（P A、g.7217G>C和g.7280T>C位点可作为猪背膘厚选育的潜在分子标记，为猪的分子育种奠定基础。