A5101883888- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Cancer-related molecular mechanisms research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Medical Research and Treatments
- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Sexual Differentiation and Disorders
- Autoimmune Neurological Disorders and Treatments
- Medical Imaging and Pathology Studies
- Endoplasmic Reticulum Stress and Disease
- GDF15 and Related Biomarkers
- Myasthenia Gravis and Thymoma
- Galectins and Cancer Biology
- Bone and Dental Protein Studies
- Thyroid Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Protease and Inhibitor Mechanisms
- Hematological disorders and diagnostics
- Urological Disorders and Treatments
- Vitamin C and Antioxidants Research
Chinese PLA General Hospital
2015-2022
Chinese People's Liberation Army
2013-2022
People's Liberation Army No. 150 Hospital
2013
Jiangxi Provincial People's Hospital
2013
Abstract Long noncoding RNAs (lncRNAs) are involved in diabetes related diseases. However, the role of lncRNAs pathogenesis type 2 with macrovascular complication (DMC) has seldomly been recognized. This study screened lncRNA profiles leukocytes from DMC patients and explored protective LYPLAL1-DT endothelial cells (EC) under high glucose (HG) inflammatory conditions (IS). Between healthy controls, 477 differential expression (DE-lncRNAs) were identified. The enrichment pathway analysis...
Aim . To investigate the clinical and endocrinological characteristics of patients with adrenal incidentaloma (AI). Materials Methods This retrospective study enrolled 1941 AI hospitalized at Department Endocrinology, Chinese PLA General Hospital, Beijing, China, between January 1997 December 2016. The patient gender, age visits, imaging features, functional status, histological results were analyzed. Results Of patients, 984 (50.70%) men. median was 52 years (interquartile range: 44–69...
Primary adrenal lymphoma (PAL) is a rare form of mass. We summarize our experience in its clinical presentation, biochemical indexes, radiological features, pathological information, therapy regimens, and outcomes.This was an institutional review board-approved retrospective medical records surgical pathology specimens patients with diagnosis PAL at the Chinese People's Liberation Army General Hospital First Affiliate Xiamen University between July 2007 2017.Twenty-six were identified. The...
Background/Aims: Chronic inflammation contributes to the development of type 2 diabetes mellitus by targeting insulin receptor substrate protein-1 (IRS-1) signaling pathway. Previous studies showed that Leukemia related protein 16 (LRP16) reduced stimulated glucose uptake in adipocytes impairing IRS-1 We explored mechanism which LRP16 promotes inflammatory response. Methods: screened induced proteins lipopolysaccharide (LPS)-stimulated response using liquid chromatography-mass spectrometry...
Aim . To investigate incidental adrenal enlargement clinical characteristics and functional status analyze lesion risk factors. Materials Methods This retrospective study included 578 patients with imaging features showing enlargement. Incidental cases (78) were considered eligible. Demographics, diagnosis, features, concomitant diseases analyzed. Results The number of enlargements proportion increased each year. Mean patient age was 50.32 years. Thirty-nine had unilateral on the left side 3...
Osteogenesis imperfecta (OI) is a family of genetic disorders associated with bone loss and fragility. Mutations OI have been found in genes encoding the type I collagen chains. People often produce insufficient α1-chain because frameshift, nonsense, or splice site mutations COL1A1 COL1A2. This report Chinese daughter mother who had both experienced two fractures. Because skeletal fragility predominantly inherited, we focused on identifying COL1A2 genes. A novel mutation COL1A1, c.700delG,...
Long noncoding RNAs (lncRNAs) regulate gene expression at different levels in various diseases, including type 1 diabetes (T1D). However, the of circulating lncRNAs leukocytes T1D has not been well documented. To identify differentially expressed between patients and healthy controls, RNA sequencing was performed on samples collected from both persons patients. The categories, enriched pathways, coexpression networks, characteristics novel were analyzed to provide an extensive profile. qPCR...
Objective To study whether preoperative serum thyrotropin （TSH） concentration can be used for risk prediction of papillary thyroid microcarcinoma （ PTMC ）. Methods The cohort this retrospective consisted 1 707 patients who underwent surgery on nodules at Chinese PLA General Hospital from October 1999 to February 2011. 37.32% n = 637） these suffered differentiated cancer DTC ）, and 14.18 % 242） with PTMC. Results ） mean TSH level in was significantly higher than that benign [ 1.99（1.25-3.19）...
目的通过构建bcl-6基因野生型、突变体3＇UTR区及其编码序列（CDS）,观察miR-127对bcl-6的直接靶向调控作用及bcl-6表达载体回复miR-127抑制细胞周期和细胞生长的功能。方法利用PCR方法扩增bcl-6基因3＇UTR区序列及其CDS,分别构建在pc DNA3.0-Luc和pc DNA3.0-Flag载体上,在bcl-6基因3＇UTR质粒基础上应用重组PCR方法构建miR-127结合位点突变的突变体报告基因质粒,应用荧光素酶报告基因系统检测miR-127对bcl-6的直接靶向调控作用,在肝癌细胞Hep G2中检测过表达及敲低miR-127引起bcl-6基因表达抑制后细胞周期和细胞生长的改变,同时应用表达载体回复bcl-6蛋白水平,检测bcl-6在miR-127调控细胞周期和细胞生长中的必要性。结果构建的重组质粒经酶切鉴定和测序证实构建正确,bcl-6 3＇UTR野生型和突变体报告质粒与miR-127共转293T细胞和Hep G2细胞后荧光素酶报告基因检测显示miR-127明显降低野生型报告质粒的活性,但对突变体活性没有影响,miR-127可引起Hep...
Ovoteslis is a rare disorder of sexual differentiation in which the gonads have both ovarian and testicular elemenls. The patients always Present wilh ambiguous external genitalia, there are usually with serious between chromosomal sex, gonadal social psychological sex. definite diagnosis gender coufimalion, appropriate surgery internal genitalia orthomorphia as well support essential for multidisciplinary medical group managing this disease. data two children ovotestis who were reared boy...
Objective To describe a case of female sexual abnormality with 46, XX caused by an androgen- producing adrenocortical tumor and to explore the mechanism abnormal androgen secretion from tumor. Methods The tissues as experimental group were compared normal adrenal tissue. LH/human chorionic gonadotropin （hCG） receptor was determined immunohistochemisty, activity 3β-hydroxysteroid dehydrogenase （ 3β-HSD ）, 17α-hydroxylase CYP17 17β-hydroxysteroid oxidoreductase 17β-HSD ） enzyme linked...
初冬时节的杭州,依然暖意融融.2013年11月16日至17日,中华内分泌学分会性腺学组第三届糖尿病及性腺疾病学术会议在美丽的西子湖畔隆重举行.来自全国各地450余名老中青代表齐聚一堂,就近年来国内外内分泌性腺疾病及糖尿病相关领域的研究进展以及重点、热点和难点等进行了学习和讨论交流.大会由中华医学会内分泌学分会性腺学组组长、中国人民解放军总医院内分泌科窦京涛教授主持,中华内分泌学分会候任主任委员、性腺学组名誉组长母义明教授致开幕辞.母义明教授回顾了性腺学组从组建至今的成长历程,以及为普及和提高国内性腺疾病诊疗水平所做的努力,并对下一届学组的工作提出了殷切期望.本次大会采取了灵活多样的形式,其中包括专家讲座、专题论坛和经典病例讨论等,充分展示了国内内分泌性腺疾病研究和临床实践工作的欣欣向荣面貌.大会主要就以下内容进行了交流。
2014年7月3日至5日由中华医学会内分泌学分会性腺学组举办的第四届全国糖尿病和性腺疾病学术会议在清爽美丽的贵州省贵阳市召开.本次大会注册代表547人,共收到全国各省、市、自治区及解放军系统的论文50篇,组织15场专题报告(包括3场病例讨论).开幕式由中华医学会内分泌学分会性腺组组长、中国人民解放军总医院内分泌科窦京涛教授主持,中华医学会内分泌学分会候任主任委员、性腺学组名誉组长母义明教授致开幕辞.在开幕辞中,母义明教授对目前性腺疾病引起了越来越多内分泌代谢和相关专业临床医生的兴趣和关注给予了肯定,也指出国内性腺疾病临床和基础研究的不足、性腺疾病领域的研究缺乏合作等目前存在的问题;性腺疾病的特点决定了其研究需要跨地域、跨学科、长时间的细致观察,也对内分泌代谢专业医生跨地域、跨学科合作提出挑战。
Parathyroid carcinoma (PC) is a rare neoplasm that accounts for 0.1%-5% of primary hyperparathyroidism cases. Hyperparathyroidism-induced hypercalcemic crisis (HHC) sometimes due to single PC.1 However, lack definitive diagnostic markers and overlapping clinical features this condition with adenomas, it has been difficult diagnose.2 In report, we investigated the preoperative management, presentation, surgical histopathological findings, outcomes six patients presented PC initiated by HCC....
本指南采用GRADE (Grading of Recommendations,Assessment,Development,and Evaluation)系统来描述推荐等级和证据质量.就推荐等级而言,强烈推荐用词语“推荐”和数字“1”表示,较弱推荐用“建议”和数字“2”表示.“+”代表证据质量,“+”表示证据极不充分;“++”表示证据不充分;“+++”表示证据充分;“++++”表示证据相当充分。