A5011541680- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Adrenal Hormones and Disorders
- Thyroid Cancer Diagnosis and Treatment
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Gout, Hyperuricemia, Uric Acid
- Pancreatic function and diabetes
- Cardiovascular Health and Risk Factors
- Thyroid Disorders and Treatments
- Mesenchymal stem cell research
- Diet and metabolism studies
- Immune cells in cancer
- Ovarian cancer diagnosis and treatment
- Cardiovascular Health and Disease Prevention
- Sexual Differentiation and Disorders
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and disorders
- Neuroendocrine Tumor Research Advances
- Cancer-related molecular mechanisms research
Chinese PLA General Hospital
2015-2025
State Council of the People's Republic of China
2022-2024
Chinese People's Liberation Army
2021-2024
People's Liberation Army No. 150 Hospital
2021-2024
Hainan Branch of People's Liberation Army General Hospital
2024
Nankai University
2022
Chinese General Hospital College of Nursing and Liberal Arts
2022
Abstract Dysregulation of the epidermal growth factor receptor (EGFR) promotes cancer cell growth, invasion and metastasis. However, its relevant downstream effectors are still limited. Here, we show that EGFR breast tumor metastasis by downregulating suppressor micoRNA-338-3p (miR-338-3p) activating EYA2 (EYA transcriptional coactivator phosphatase 2) oncoprotein. represses miR-338-3p expression largely through HIF1 α transcription factor. inhibits binding to 3′-untranslated region EYA2....
Abstract Background To determine the efficacy and safety of umbilical cord-derived mesenchymal stem cells (UC-MSCs) in Chinese adults with type 2 diabetes mellitus (T2DM). Methods In this single-center, double-blinded, randomized, placebo-controlled phase II trial, 91 patients were randomly assigned to receive intravenous infusion UC-MSCs ( n = 45) or placebo 46) three times 4-week intervals followed up for 48 weeks from October 2015 December 2018. The primary endpoint was percentage...
Thyroid hormone influences glucose homeostasis through central and peripheral regulations. To date, the link between sensitivity to thyroid hormones prediabetes remains unknown. We aimed investigate association risk of in both general euthyroid populations.Participants with serum free triiodothyronine (FT3), thyroxine (FT4), thyrotropin (TSH) measurements from health checkup programs First Hospital China Medical University were collected. measured parameters representing sensitivities...
Graves' disease (GD) occurs due to an autoimmune dysfunction of thyroid gland cells, leading manifestations consistent with hyperthyroidism. Various studies have confirmed the link between conditions and changes in composition intestinal microbial organisms. However, few assessed relationship GD microbiota. Therefore, present study aimed investigate flora that may occur setting GD. Thirty-nine patients 17 healthy controls were enrolled for fecal sample collection. 16S rRNA sequencing was...
Over the past decades, incidence of thyroid cancer (TC) rapidly increased all over world, with papillary (PTC) accounting for vast majority TC cases.It is crucial to investigate novel diagnostic and therapeutic targets PTC explore more detailed molecular mechanisms in carcinogenesis progression PTC.Based on TCGA GEO databases, FAM111B downregulated tissues predicts better prognosis patients.FAM111B suppresses growth, migration, invasion glycolysis both vitro vivo.Furthermore, estrogen...
The hemoglobin glycation index (HGI) was developed to quantify glucose metabolism and individual differences proved be a robust measure of glycosylated (HbA1c) bias. Here, we aimed explore the relationship between different HGIs risk 5-year major adverse cardiovascular events (MACEs) by performing large multicenter cohort study in China.A total 9791 subjects from Risk Evaluation Cancers Chinese Diabetic Individuals: Longitudinal Study (the REACTION study) were divided into five subgroups...
Abstract The role of mesenchymal‐stem‐cell‐derived exosomes (MSCs‐Exo) in the regulation macrophage polarization has been recognized several diseases. There is emerging evidence that MSCs‐Exo partially prevent progression diabetic nephropathy (DN). This study aimed to investigate whether secreted by MSCs pre‐treated with a environment (Exo‐pre) have more pronounced protective effect against DN regulating balance macrophages. Exo‐pre and Exo‐Con were isolated from culture medium UC‐MSCs mimic...
Abstract Background Mesenchymal stem cells (MSCs) exert anti-diabetic effects and improve long-term complications via secretory that regulate macrophage polarisation attenuate inflammation. Enhancing the efficacy of MSCs needs to be explored further. The in vitro culture microenvironment influences profile MSCs. Therefore, we hypothesised a diabetic would promote secretion cytokines responsible for polarisation, further attenuating systemic inflammation enhancing on type 2 diabetes (T2D)...
Background Gitelman Syndrome (GS) patients frequently exhibit disrupted glucose metabolism, attributed to hypokalemia, hypomagnesemia and heightened aldosterone. This study delved into the genetic underpinnings linked insulin resistance diabetes in a GS patient, contextualized within his family history. Methods The hydrochlorothiazide furosemide loading test were performed ascertain presence of GS. Oral tolerance (OGTT) evaluated metabolism sensitivity. Whole-exome sequencing, validated by...
High levels of branched-chain amino acids (BCAAs) and aromatic (AAAs) were associated with an increased risk hyperglycemia the onset diabetes. This study is aimed at assessing circulating valine concentrations in subjects type 2 diabetes (T2D) T2D patients high-fat diet- (HFD-) fed mice treated hypoglycemic agent sitagliptin (Sit) analyzing association metabolic parameters.Metabolomics HFD-fed analyzed by gas chromatography-mass spectrometry (GC-MS) systems. Plasma detected a commercial kit...
Abstract Umbilical cord-derived mesenchymal stem cells (UC-MSCs) have been proved a promising clinical strategy for the treatment of diabetes, and time in range (TIR) has demonstrated new metric glycemic control links to diabetes complications. To further assess therapeutic effect UC-MSCs on TIR, phase II study investigating efficacy Chinese adults with type 2 (T2D) assessed by retrospective continuous glucose monitoring (CGM) was conducted. In this randomized placebo-controlled trial, total...
Abstract Objective To evaluate whether the intense simplified strategy, which comprises short term intensive insulin therapy (SIIT) followed by subsequent oral antihyperglycaemic regimens, could improve long glycaemic outcomes in patients with newly diagnosed type 2 diabetes mellitus and severe hyperglycaemia. Design Multicentre, open label, randomised trial. Setting 15 hospitals China between December 2017 2020. Participants 412 significant hyperglycaemia (HbA 1c ≥8.5%). Interventions All...
Aminophenols, which are widely used as components of hair dye and medicine, may function environmental endocrine disruptors by regulating the proliferation endocrine-related cancers. Estrogen receptor α (ERα) is a key regulator breast cancer. Recently, it was found that ERα also participate in transformation progression thyroid tumors, but its interaction with aminophenols tumors not clear. In this study, transcription factor activity BHP10-3 cells (a tumor cell line) examined using...
Primary adrenal lymphoma (PAL) is a rare form of mass. We summarize our experience in its clinical presentation, biochemical indexes, radiological features, pathological information, therapy regimens, and outcomes.This was an institutional review board-approved retrospective medical records surgical pathology specimens patients with diagnosis PAL at the Chinese People's Liberation Army General Hospital First Affiliate Xiamen University between July 2007 2017.Twenty-six were identified. The...
Abstract Background Patients with normoalbuminuria and a reduced estimated glomerular filtration rate (eGFR) account for considerable proportion of type 2 diabetes patients. The aim this research was to investigate the epidemiological clinical characteristics normoalbuminuric kidney disease in Chinese population. Methods We included 8131 diabetic patients from multicenter prospective study China. Based on eGFR urinary albumin‐to‐creatinine ratio (UACR), participants were stratified into four...
Infusion of mesenchymal stem cells (MSCs) induces polarization M2 macrophages in adipose tissue type 2 diabetes (T2D) mice. Studies have shown that were divided into four sub-phenotypes (M2a, M2b, M2c and M2d) with different functions, manuscripts also confirmed co-cultured MSCs not matched known phenotype macrophages. Therefore, our study explored the related gene expressions T2D mice with/without infusion.
Background/Aims: Chronic inflammation contributes to the development of type 2 diabetes mellitus by targeting insulin receptor substrate protein-1 (IRS-1) signaling pathway. Previous studies showed that Leukemia related protein 16 (LRP16) reduced stimulated glucose uptake in adipocytes impairing IRS-1 We explored mechanism which LRP16 promotes inflammatory response. Methods: screened induced proteins lipopolysaccharide (LPS)-stimulated response using liquid chromatography-mass spectrometry...
Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is a rare condition with untypical subclinical symptoms of Cushing's syndrome (CS). This study aimed to compare the clinical and pathological features PBMAH unilateral cortisol-secreting adrenal adenoma (UAA).We prospectively included 46 patients 205 UAA from January 2000 February 2014. Cortisol levels 24 hours urine free cortisol (UFC) were determined at baseline during dexamethasone suppression test (DST) using...