A5066440914- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Growth Hormone and Insulin-like Growth Factors
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- CRISPR and Genetic Engineering
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Peroxisome Proliferator-Activated Receptors
- Protein Tyrosine Phosphatases
- Cytokine Signaling Pathways and Interactions
- HER2/EGFR in Cancer Research
- Cancer Research and Treatments
- Retinoids in leukemia and cellular processes
- RNA Interference and Gene Delivery
- Telomeres, Telomerase, and Senescence
- Circular RNAs in diseases
- Viral Infectious Diseases and Gene Expression in Insects
- RNA and protein synthesis mechanisms
Beijing VDJBio (China)
2014-2025
Guiyang Medical University
2020-2024
Peking University
1998-2023
Peking University Cancer Hospital
1998-2023
Shanxi Medical University
2023
Czech Academy of Sciences, Institute of Biotechnology
2007-2022
Academy of Military Medical Sciences
2005-2022
Guizhou University
2020-2022
Beijing Institute of Technology
2021
First Affiliated Hospital of Zhengzhou University
2019
MicroRNAs (miRNAs) have been shown to be dysregulated in virus-related cancers; however, miRNA regulation of cancer development and progression remains poorly understood. Here, we report that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) promote growth metastasis a mouse model hepatocellular carcinoma (HCC). Hematopoietic pre-B cell leukemia transcription factor-interacting (HPIP) an important regulator growth. We used target prediction programs identify as HPIP....
The breast cancer susceptibility gene BRCA1 encodes a protein that has been implicated in multiple nuclear functions, including transcription and DNA repair. multifunctional nature of raised the possibility polypeptide may regulate various processes via common underlying mechanism such as chromatin remodeling. However, to date, no direct evidence exists mammalian cells for BRCA1-mediated changes either local or large-scale structure. Here we show targeting an amplified, lac...
Abstract Aberrant N6-methyladenosine (m6A) modification has emerged as a driver of tumor initiation and progression, yet how long noncoding RNAs (lncRNA) are involved in the regulation m6A remains unknown. Here we utilize data from 12 cancer types The Cancer Genome Atlas to comprehensively map lncRNAs that potentially deregulated by DNA methylation. A novel methylation–deregulated RNA reader–cooperating lncRNA (DMDRMR) facilitated growth metastasis clear cell renal carcinoma (ccRCC)....
Abstract Dysregulation of the epidermal growth factor receptor (EGFR) promotes cancer cell growth, invasion and metastasis. However, its relevant downstream effectors are still limited. Here, we show that EGFR breast tumor metastasis by downregulating suppressor micoRNA-338-3p (miR-338-3p) activating EYA2 (EYA transcriptional coactivator phosphatase 2) oncoprotein. represses miR-338-3p expression largely through HIF1 α transcription factor. inhibits binding to 3′-untranslated region EYA2....
Cholesterol increases the risk of aggressive prostate cancer and has emerged as a potential therapeutic target for cancer. The functional roles cholesterol in metastasis are not fully understood. Here, we found that induces epithelial-to-mesenchymal transition (EMT) through extracellular-regulated protein kinases 1/2 pathway activation, which is mediated by EGFR adipocyte plasma membrane-associated (APMAP) accumulation cholesterol-induced lipid rafts. Mechanistically, APMAP interaction with...
Abstract Osteosarcoma (OS) has emerged as the most common primary musculoskeletal malignant tumour affecting children and young adults. Cyclin-dependent kinases (CDKs) are closely associated with gene regulation in biology. Accumulating evidence indicates that aberrant function of CDK14 is involved a broad spectrum diseases clinical outcomes. MicroRNAs (miRNAs) crucial epigenetic regulators development OS. However, essential role molecular mechanisms by which miRNAs regulate oncogenesis...
Four and a half Lin-11, Isl-1, Mac-3 (LIM) protein 1 (FHL1) has been linked to carcinogenesis. However, the role of FHL1 in lung cancer remains unclear detailed mechanism underlying its tumor suppressive is poorly understood. The purpose this study was examine expression patients investigate how it associated with cell growth. Immunoblotting immunohistochemistry showed that downregulated over 90% 80 patients. strongly correlated histological types (p < 10(-4) ) differentiation = 0.002)....
Estrogen receptors ERα and ERβ share considerable sequence homology yet exert opposite effects on breast cancer cell proliferation. While the proliferative role of in tumors is well characterized, it not clear whether antitumor activity can be mobilized cells. Here, we have shown that phosphorylation a tyrosine residue (Y36) present ERβ, but ERα, dictates ERβ-specific activation transcription required for ERβ-dependent inhibition growth culture murine xenografts. Additionally, c-ABL kinase...
Triple-negative breast cancer (TNBC) is known for its aggressive phenotype with limited treatment modalities and poor prognosis. The Warburg effect (aerobic glycolysis) a hallmark of that serves as promising target diagnosis therapy. However, how aerobic glycolysis regulates TNBC remains largely unknown. Here, we show the glucose transporter (GLUT) family member GLUT12 promotes tumor growth metastasis in vitro vivo through regulating glycolysis. MicroRNA let-7a-5p, suppressor, inhibited...
Osteoarthritis (OA) has been recognized as the most common chronic age-related disease. Cartilage degeneration influences OA therapy. Here we report that hematopoietic pre-B cell leukemia transcription factor-interacting protein (HPIP) is essential for development. Elevated HPIP levels are found in patients. Col2a1-CreERT2/HPIPf/f mice exhibit obvious skeletal abnormalities compared with their HPIPf/f littermates. deficiency protects against developing OA. Moreover, intra-articular injection...
Lung adenocarcinoma (LUAD) is a common type of lung cancer with high frequent metastasis and death rate.However, genes responsible for LUAD are still largely unknown.Here, we identify an important role ras homolog family member V (RHOV) in using combination bioinformatic analysis functional experiments.Bioinformatic shows five hub driver (RHOV, ZIC5, CYP4B1, GPR18 TCP10L2), among which RHOV the most significant gene associated metastasis.High expression predicted shorter overall survival...
Lysosome plays important roles in cellular homeostasis, and its dysregulation contributes to tumor growth survival. However, the understanding of regulation underlying mechanism lysosome cancer survival is incomplete. Here, we reveal a role for histone acetylation-regulated long noncoding RNA termed cell death regulator (LCDR) lung survival, which knockdown promotes apoptosis. Mechanistically, LCDR binds heterogenous nuclear ribonucleoprotein K (hnRNP K) regulate stability...
Abstract Background Altered lipid metabolism is closely related to the occurrence and development of hepatocellular carcinoma (HCC). Carnitine palmitoyltransferase 1C (CPT1C) a member CPT1 family plays key role in cancer progression. However, how microRNAs (miRNAs) regulate CPT1C-mediated fatty acid transport oxidation remains be elucidated. Methods Oil Red O staining, mitochondrial, droplets immunofluorescence staining were used detect functions miR-377-3p CPT1C oxidation. Colocalization...
The initiation of breast cancer is associated with increased expression tumor-promoting estrogen receptor α (ERα) protein and decreased tumor-suppressive ERβ protein. However, the mechanism underlying this process unknown. Here we show that PES1 (also known as Pescadillo), an estrogen-inducible overexpressed in cancer, can regulate balance between ERα ERβ. We found modulated many estrogen-responsive genes by enhancing transcriptional activity while inhibiting Consistent regulation activity,...
Shigella species possess a type III secretion system (T3SS), which is required for human infection and that delivers effector proteins into target host cells. Here, we show the effector, IpaH4.5 dampens pro-inflammatory cytokine response. In both Sereny test murine lung model, ΔipaH4.5 mutant strain caused more severe inflammatory responses significantly induced higher levels (MIP-2 TNF-α) in homogenates of wild type-infected mice. Moreover, there was threefold decrease bacterial...
// Yanan Zhang 1, 2 , Jie Liu 1 Jing Lin 3 Lei Zhou 4 Yuhua Song 5 Bo Wei 6 Xiaoli Luo Zhida Chen Yingjie Jiaxiu Xiong Xiaojie Xu Lihua Ding Qinong Ye Department of Medical Molecular Biology, Beijing Institute Biotechnology, Collaborative Innovation Center for Cancer Medicine, Beijing, People's Republic China Stem Cell, Center, Dalian University, Liaoning, First Affiliated Hospital, Chinese PLA General Shijitan Capital The Hospital Qing Dao Qingdao, Surgery, Correspondence to: Ye, e-mail:...
FHL1 is an important tumor-suppressor that downregulated in multiple tumors by unknown mechanisms. We demonstrated miR-410 specifically targets the 3′UTR of FHL1. Furthermore, using DNA bisulfite modification and sequencing experiments, we promoter hypermethylated cancer cells. methylation increased upon expression, suggesting regulation occurs a dual mechanism. Using chromatin immunoprecipitation assays, observed overexpression results binding DNMT3A at promoter, which could explain how...
Abstract Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (HPIP) was shown to play a role in cancer development and progression. However, the of HPIP colorectal (CRC) is unknown. Here, we report that overexpressed most CRC patients predicts poor clinical outcome CRC. promotes proliferation via activation G1/S G2/M checkpoint transitions, concomitant with marked increase positive cycle regulators, including cyclin D1, A B1. inhibits apoptosis accompanied by...