A5008964056- Cardiovascular Function and Risk Factors
- Metastasis and carcinoma case studies
- Cardiac Imaging and Diagnostics
- Genomics, phytochemicals, and oxidative stress
- Adrenal Hormones and Disorders
- Diabetes Management and Research
- Gout, Hyperuricemia, Uric Acid
- Heme Oxygenase-1 and Carbon Monoxide
- Parvovirus B19 Infection Studies
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- Pituitary Gland Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Health and Disease Prevention
- Genital Health and Disease
- Histiocytic Disorders and Treatments
- Diabetes Treatment and Management
Sun Yat-sen University
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Affiliated Hospital of Guangdong Medical College Hospital
2024
Guangdong Medical College
2024
Abstract Context Cushing disease, a chronic hypercortisolism disorder, is associated with considerable morbidity and mortality. Normalizing cortisol production the primary treatment goal. Objective We aimed to evaluate safety efficacy of osilodrostat, potent, orally available 11βhydroxylase inhibitor, compared placebo in patients disease. Methods LINC 4 was phase III, multicenter trial comprising an initial 12-week, randomized, double-blind, placebo-controlled (osilodrostat:placebo, 2:1)...
Abstract Uric acid (UA) is the end product of purine metabolism. In recent years, UA has been found to be associated with prognosis clinical cancer patients. However, intricate mechanisms by which affects development and tumor patients not well elucidated. this study, we explored role in breast cancer, scrutinizing its impact on cell function treating two types lines UA. The cycle proliferation tumors underlying were further investigated. We that antioxidant effect facilitated scavenging...
Abstract Objective To evaluate whether the intense simplified strategy, which comprises short term intensive insulin therapy (SIIT) followed by subsequent oral antihyperglycaemic regimens, could improve long glycaemic outcomes in patients with newly diagnosed type 2 diabetes mellitus and severe hyperglycaemia. Design Multicentre, open label, randomised trial. Setting 15 hospitals China between December 2017 2020. Participants 412 significant hyperglycaemia (HbA 1c ≥8.5%). Interventions All...
Summary Erdheim-Chester disease (ECD), one type of systemic non-Langerhans cell histiocytosis, has been rarely seen and is characterized by the accumulation foamy CD68+CD1a- histiocytes. We reported a case ECD reviewed clinical features 13 cases so far in China. A 53-year-old male was diagnosed with central diabetes insipidus March 2014, followed fever, splenomegaly anemia July 2014. His initial pituitary magnetic resonance imaging (MRI) revealed absence high signal at T1-weighted image...